Cell biology of myelin wrapping, plasticity and turnover

Project Information

Myelination

Grant agreement ID: 647168

DOI

10.3030/647168

Project closed

EC signature date 5 May 2015

Start date 1 August 2015

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 872 500,00

EU contribution

€ 1 872 500,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Cell type– and brain region–resolved mouse brain proteome

Author(s): Kirti Sharma, Sebastian Schmitt, Caroline G Bergner, Stefka Tyanova, Nirmal Kannaiyan, Natalia Manrique-Hoyos, Karina Kongi, Ludovico Cantuti, Uwe-Karsten Hanisch, Mari-Anne Philips, Moritz J Rossner, Matthias Mann, Mikael Simons
Published in: Nature Neuroscience, Issue 18/12, 2015, Page(s) 1819-1831, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4160

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Author(s): Maria Inês Cunha, Minhui Su, Ludovico Cantuti-Castelvetri, Stephan A. Müller, Martina Schifferer, Minou Djannatian, Ioannis Alexopoulos, Franziska van der Meer, Anne Winkler, Tjakko J. van Ham, Bettina Schmid, Stefan F. Lichtenthaler, Christine Stadelmann, Mikael Simons
Published in: Journal of Experimental Medicine, Issue 217/5, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20191390

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

Author(s): Chaitali Mukherjee, Tina Kling, Belisa Russo, Kerstin Miebach, Eva Kess, Martina Schifferer, Liliana D. Pedro, Ulrich Weikert, Maryam K. Fard, Nirmal Kannaiyan, Moritz Rossner, Marie-Louise Aicher, Sandra Goebbels, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Anja Schneider, Mikael Simons
Published in: Cell Metabolism, Issue 32/2, 2020, Page(s) 259-272.e10, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.019

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Author(s): Maryam K. Fard, Franziska van der Meer, Paula Sánchez, Ludovico Cantuti-Castelvetri, Sunit Mandad, Sarah Jäkel, Eugenio F. Fornasiero, Sebastian Schmitt, Marc Ehrlich, Laura Starost, Tanja Kuhlmann, Christina Sergiou, Verena Schultz, Claudia Wrzos, Wolfgang Brück, Henning Urlaub, Leda Dimou, Christine Stadelmann, Mikael Simons
Published in: Science Translational Medicine, Issue 9/419, 2017, Page(s) eaam7816, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam7816

Defective cholesterol clearance limits remyelination in the aged central nervous system

Author(s): Ludovico Cantuti-Castelvetri, Dirk Fitzner, Mar Bosch-Queralt, Marie-Theres Weil, Minhui Su, Paromita Sen, Torben Ruhwedel, Miso Mitkovski, George Trendelenburg, Dieter Lütjohann, Wiebke Möbius, Mikael Simons
Published in: Science, 2018, Page(s) eaan4183, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan4183

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Author(s): Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Published in: Cell Reports, Issue 18/2, 2017, Page(s) 314-323, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.12.053

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Author(s): Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
Published in: Cell Reports, Issue 16/2, 2016, Page(s) 314-322, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.06.008

Age-related myelin degradation burdens the clearance function of microglia during aging

Author(s): Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L Edinger, Steffen Jung, Moritz J Rossner, Mikael Simons
Published in: Nature Neuroscience, Issue 19/8, 2016, Page(s) 995-998, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/nn.4325

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Author(s): Ludovico Cantuti-Castelvetri, Ravi Ojha, Liliana D. Pedro, Minou Djannatian, Jonas Franz, Suvi Kuivanen, Franziska van der Meer, Katri Kallio, Tuğberk Kaya, Maria Anastasina, Teemu Smura, Lev Levanov, Leonora Szirovicza, Allan Tobi, Hannimari Kallio-Kokko, Pamela Österlund, Merja Joensuu, Frédéric A. Meunier, Sarah J. Butcher, Martin Sebastian Winkler, Brit Mollenhauer, Ari Helenius, Ozgun Gok
Published in: Science, Issue 370/6518, 2020, Page(s) 856-860, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abd2985

Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

Author(s): Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Möbius, Martina Schifferer, Elior Peles, Mikael Simons
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12789-z

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome

Author(s): Dirk Fitzner, Jakob M. Bader, Horst Penkert, Caroline G. Bergner, Minhui Su, Marie-Theres Weil, Michal A. Surma, Matthias Mann, Christian Klose, Mikael Simons
Published in: Cell Reports, Issue 32/11, 2020, Page(s) 108132, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108132

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Author(s): Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Schifferer, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lütjohann, Christian Klose, Lenka Vaculčiaková, Takahiro Masuda, Marco Prinz, Kathryn M. Monroe, Gilbert Di Paolo, Joseph W. Lewcock, Christian Haass, Mikael Simons
Published in: Nature Metabolism, Issue 3/2, 2021, Page(s) 211-227, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-021-00341-7