Molecular and cellular determinants of cell monolayer mechanics

Project Information

MolCellTissMech

Grant agreement ID: 647186

DOI 10.3030/647186

Project closed

EC signature date 31 July 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

Publications

Peer reviewed articles (16)

Fractional viscoelastic models for power-law materials

Author(s): A. Bonfanti, J. L. Kaplan, G. Charras, A. Kabla
Published in: Soft Matter, Issue 16/26, 2020, Page(s) 6002-6020, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm00354a

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

Author(s): Luyan Cao, Amina Yonis, Malti Vaghela, Elias H. Barriga, Priyamvada Chugh, Matthew B. Smith, Julien Maufront, Geneviève Lavoie, Antoine Méant, Emma Ferber, Miia Bovellan, Art Alberts, Aurélie Bertin, Roberto Mayor, Ewa K. Paluch, Philippe P. Roux, Antoine Jégou, Guillaume Romet-Lemonne, Guillaume Charras
Published in: Nature Cell Biology, Issue 22/7, 2020, Page(s) 803-814, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0531-y

Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle

Author(s): Maxine S. Y. Lam, Ana Lisica, Nitya Ramkumar, Ginger Hunter, Yanlan Mao, Guillaume Charras, Buzz Baum
Published in: Molecular Biology of the Cell, Issue 31/13, 2020, Page(s) 1370-1379, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e19-09-0545

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

Author(s): Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor
Published in: Nature, Issue 554/7693, 2018, Page(s) 523-527, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature25742

The dynamic mechanical properties of cellularised aggregates

Author(s): Nargess Khalilgharibi, Jonathan Fouchard, Pierre Recho, Guillaume Charras, Alexandre Kabla
Published in: Current Opinion in Cell Biology, Issue 42, 2016, Page(s) 113-120, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2016.06.003

A question of time: tissue adaptation to mechanical forces

Author(s): Wyatt Thomas, Charras Guillaume, Baum Buzz
Published in: Current Opinion in Cell Biology, 2016, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2016.02.012

Optogenetic control of cellular forces and mechanotransduction

Author(s): Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras, Xavier Trepat
Published in: Nature Communications, Issue 8, 2017, Page(s) 14396, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14396

Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress

Author(s): Maria Duda, Natalie J. Kirkland, Nargess Khalilgharibi, Melda Tozluoglu, Alice C. Yuen, Nicolas Carpi, Anna Bove, Matthieu Piel, Guillaume Charras, Buzz Baum, Yanlan Mao
Published in: Developmental Cell, Issue 48/2, 2019, Page(s) 245-260.e7, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2018.12.020

Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex

Author(s): Nargess Khalilgharibi, Jonathan Fouchard, Nina Asadipour, Ricardo Barrientos, Maria Duda, Alessandra Bonfanti, Amina Yonis, Andrew Harris, Payman Mosaffa, Yasuyuki Fujita, Alexandre Kabla, Yanlan Mao, Buzz Baum, José J Muñoz, Mark Miodownik, Guillaume Charras
Published in: Nature Physics, Issue 15/8, 2019, Page(s) 839-847, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-019-0516-6

Curling of epithelial monolayers reveals coupling between active bending and tissue tension

Author(s): Jonathan Fouchard, Tom P. J. Wyatt, Amsha Proag, Ana Lisica, Nargess Khalilgharibi, Pierre Recho, Magali Suzanne, Alexandre Kabla, Guillaume Charras
Published in: Proceedings of the National Academy of Sciences, Issue 117/17, 2020, Page(s) 9377-9383, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1917838117

Actomyosin controls planarity and folding of epithelia in response to compression

Author(s): Tom P. J. Wyatt, Jonathan Fouchard, Ana Lisica, Nargess Khalilgharibi, Buzz Baum, Pierre Recho, Alexandre J. Kabla, Guillaume T. Charras
Published in: Nature Materials, Issue 19/1, 2020, Page(s) 109-117, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-019-0461-x

A unified rheological model for cells and cellularised materials

Author(s): A. Bonfanti, J. Fouchard, N. Khalilgharibi, G. Charras, A. Kabla
Published in: Royal Society Open Science, Issue 7/1, 2020, Page(s) 190920, ISSN 2054-5703
Publisher: Royal Society
DOI: 10.1098/rsos.190920

Mechanics of the cellular actin cortex: From signalling to shape change

Author(s): Manasi Kelkar, Pierre Bohec, Guillaume Charras
Published in: Current Opinion in Cell Biology, Issue 66, 2020, Page(s) 69-78, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.05.008

Substrate area confinement is a key determinant of cell velocity in collective migration

Author(s): Danahe Mohammed, Guillaume Charras, Eléonore Vercruysse, Marie Versaevel, Joséphine Lantoine, Laura Alaimo, Céline Bruyère, Marine Luciano, Karine Glinel, Geoffrey Delhaye, Olivier Théodoly, Sylvain Gabriele
Published in: Nature Physics, Issue 15/8, 2019, Page(s) 858-866, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-019-0543-3

Cortical cell stiffness is independent of substrate mechanics

Author(s): Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze
Published in: Nature Materials, Issue 19/9, 2020, Page(s) 1019-1025, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-0684-x

Tug-of-war between stretching and bending in living cell sheets

Author(s): P. Recho, J. Fouchard, T. Wyatt, N. Khalilgharibi, G. Charras, A. Kabla
Published in: Physical Review E, Issue 102/1, 2020, ISSN 2470-0045
Publisher: American Physical Society
DOI: 10.1103/physreve.102.012401