Periodic Reporting for period 3 - EXODUS (Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation)
Reporting period: 2018-09-01 to 2020-02-29
Autoimmunity in general and CNS autoimmunity in particular target young adults and are not yet curable. Therefore, they deposit a significant personal burden on affected individuals and a significant socioeconomic burden on society. Novel therapeutic approaches aiming at the activation of the immune system at barrier sites have been proposed and some of these novel ideas even try to manipulate the microbiome to eventually modulate immune responses at distant sites. However, due to the substantial gaps in knowledge how immune responses at barrier tissues are ""translated"" into distant organs such as the CNS, these approaches must be considered as immature.
This is the broader context of the current ERC project. Specifically, the major aims of this project are (1) to identify relevant antigen presenting cells at priming sites of autoreactive T cell, and here we chose to focus on IL-6 producing antigen presenting cells because IL-6 is a non-redundant factor in the generation of tissue pathogenic autoreactive T cells. And (2) to develop provenance mapping systems that would allow us to actually track immune cells from sites of priming to target tissues of autoimmune diseases like the CNS and also to assess the egress of immune cells from affected organs of autoimmune diseases.
Until the end of the project, we expect to be able to have established fundamentally novel tools to map the spatial provenance of migratory cells (immune cells and non-immune cells) that are found in the CNS or any other parenchymal organ.