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Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation

Publications

Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity

Author(s): Meike Mitsdoerffer, Giovanni Di Liberto, Sarah Dötsch, Christopher Sie, Ingrid Wagner, Monika Pfaller, Mario Kreutzfeldt, Simon Fräßle, Lilian Aly, Benjamin Knier, Dirk H Busch, Doron Merkler, Thomas Korn
Published in: Brain, Issue 144/6, 2021, Page(s) 1697-1710, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awab093

Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

Author(s): Michael Hiltensperger, Eduardo Beltrán, Ravi Kant, Sofia Tyystjärvi, Gildas Lepennetier, Helena Domínguez Moreno, Isabel J. Bauer, Simon Grassmann, Sebastian Jarosch, Kilian Schober, Veit R. Buchholz, Selin Kenet, Christiane Gasperi, Rupert Öllinger, Roland Rad, Andreas Muschaweckh, Christopher Sie, Lilian Aly, Benjamin Knier, Garima Garg, Ali M. Afzali, Lisa Ann Gerdes, Tania Kümpfel, Sören
Published in: Nature Immunology, Issue 22/7, 2021, Page(s) 880-892, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00948-8

Dendritic cells in central nervous system autoimmunity

Author(s): Christopher Sie, Thomas Korn
Published in: Seminars in Immunopathology, Issue 39/2, 2017, Page(s) 99-111, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-016-0608-7

Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis

Author(s): Nikolaus Feucht, Mathias Maier, Gildas Lepennetier, Moritz Pettenkofer, Carmen Wetzlmair, Tanja Daltrozzo, Pauline Scherm, Claus Zimmer, Muna-Miriam Hoshi, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Published in: Multiple Sclerosis Journal, Issue 25/2, 2019, Page(s) 224-234, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/1352458517750009

Interleukin-6: designing specific therapeutics for a complex cytokine

Author(s): Christoph Garbers, Sylvia Heink, Thomas Korn, Stefan Rose-John
Published in: Nature Reviews Drug Discovery, Issue ePub ahead of print, 2018, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/nrd.2018.45

IL-1β and IL-23 Promote Extrathymic Commitment of CD27 + CD122 − γδ T Cells to γδT17 Cells

Author(s): Andreas Muschaweckh, Franziska Petermann, Thomas Korn
Published in: The Journal of Immunology, Issue 199/8, 2017, Page(s) 2668-2679, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1700287

Deletional tolerance prevents AQP4-directed autoimmunity in mice

Author(s): Anna-Lena Vogel, Benjamin Knier, Katja Lammens, Sudhakar Reddy Kalluri, Tanja Kuhlmann, Jeffrey L. Bennett, Thomas Korn
Published in: European Journal of Immunology, Issue 47/3, 2017, Page(s) 458-469, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646855

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

Author(s): Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly, Christiane Gasperi, Veronika Husterer, Andrew L Croxford, Katja Möller-Hackbarth, Harald S Bartsch, Karl Sotlar, Stefan Krebs, Tommy Regen, Helmut Blum, Bernhard Hemmer, Thomas Misgeld, Thomas F Wunderlich, Juan Hidalgo, Mohamed Oukka, Stefan Rose-John, Marc Schmidt-Supprian, Ari Waisman, Thomas Korn
Published in: Nature Immunology, Issue 18/1, 2016, Page(s) 74-85, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3632

T cell responses in the central nervous system

Author(s): Thomas Korn, Axel Kallies
Published in: Nature Reviews Immunology, Issue 17/3, 2017, Page(s) 179-194, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2016.144

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins

Author(s): Christopher Sie, Laura Garcia Perez, Mario Kreutzfeldt, Maria Potthast, Caspar Ohnmacht, Doron Merkler, Samuel Huber, Anne Krug, Thomas Korn
Published in: The Journal of Immunology, Issue 203/6, 2019, Page(s) 1417-1427, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900468

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Author(s): Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H. Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen Huehn, Axel Kallies, Thomas Korn
Published in: Cell Reports, Issue 26/7, 2019, Page(s) 1854-1868.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.01.070

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

Author(s): Benjamin Knier, Michael Hiltensperger, Christopher Sie, Lilian Aly, Gildas Lepennetier, Thomas Engleitner, Garima Garg, Andreas Muschaweckh, Meike Mitsdörffer, Uwe Koedel, Bastian Höchst, Percy Knolle, Matthias Gunzer, Bernhard Hemmer, Roland Rad, Doron Merkler, Thomas Korn
Published in: Nature Immunology, Issue 19/12, 2018, Page(s) 1341-1351, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0237-5

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

Author(s): Tobias Baumann, Andreas Dunkel, Christian Schmid, Sabine Schmitt, Michael Hiltensperger, Kerstin Lohr, Vibor Laketa, Sainitin Donakonda, Uwe Ahting, Bettina Lorenz-Depiereux, Jan E. Heil, Johann Schredelseker, Luca Simeoni, Caroline Fecher, Nina Körber, Tanja Bauer, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Kilian Eyerich, Stefanie Eyerich, Martina Anton, Matthew Streeter, Tina Wang, B
Published in: Nature Immunology, Issue 21/5, 2020, Page(s) 555-566, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0666-9

Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

Author(s): Ilgiz A. Mufazalov, David Andruszewski, Carsten Schelmbauer, Sylvia Heink, Michaela Blanfeld, Joumana Masri, Yilang Tang, Rebecca Schüler, Christina Eich, F. Thomas Wunderlich, Susanne H. Karbach, Jeffrey A. Bluestone, Thomas Korn, Ari Waisman
Published in: The Journal of Immunology, Issue 204/4, 2020, Page(s) 747-751, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900876

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

Author(s): Anna Śledzińska, Maria Vila de Mucha, Katharina Bergerhoff, Alastair Hotblack, Dafne Franz Demane, Ehsan Ghorani, Ayse U. Akarca, Maria A.V. Marzolini, Isabelle Solomon, Frederick Arce Vargas, Martin Pule, Masahiro Ono, Benedict Seddon, George Kassiotis, Charlotte E. Ariyan, Thomas Korn, Teresa Marafioti, Graham M. Lord, Hans Stauss, Richard G. Jenner, Karl S. Peggs, Sergio A. Quezada
Published in: Immunity, Issue 52/1, 2020, Page(s) 151-166.e6, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2019.12.007

Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments

Author(s): Thomas Korn, Andreas Muschaweckh
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.02634

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells

Author(s): Andreas Muschaweckh, Veit R. Buchholz, Anne Fellenzer, Christian Hessel, Paul-Albert König, Sha Tao, Ronny Tao, Mathias Heikenwälder, Dirk H. Busch, Thomas Korn, Wolfgang Kastenmüller, Ingo Drexler, Georg Gasteiger
Published in: Journal of Experimental Medicine, Issue 213/13, 2016, Page(s) 3075-3086, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20160888

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Author(s): Caroline Fecher, Laura Trovò, Stephan A. Müller, Nicolas Snaidero, Jennifer Wettmarshausen, Sylvia Heink, Oskar Ortiz, Ingrid Wagner, Ralf Kühn, Jana Hartmann, Rosa Maria Karl, Arthur Konnerth, Thomas Korn, Wolfgang Wurst, Doron Merkler, Stefan F. Lichtenthaler, Fabiana Perocchi, Thomas Misgeld
Published in: Nature Neuroscience, Issue 22/10, 2019, Page(s) 1731-1742, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-019-0479-z

Role of IL-6 in the commitment of T cell subsets

Author(s): Thomas Korn, Michael Hiltensperger
Published in: Cytokine, Issue 146, 2021, Page(s) 155654, ISSN 1043-4666
Publisher: Academic Press
DOI: 10.1016/j.cyto.2021.155654

Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis

Author(s): L. Aly, J. Havla, G. Lepennetier, T. F. M. Andlauer, C. Sie, E.‐M. Strauß, M.‐M. Hoshi, T. Kümpfel, M. Hiltensperger, M. Mitsdoerffer, M. Mühlau, C. Zimmer, B. Hemmer, T. Korn, B. Knier
Published in: European Journal of Neurology, Issue 27/11, 2020, Page(s) 2217-2224, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.14416

Repositioning TH cell polarization from single cytokines to complex help

Author(s): Selma Tuzlak, Anne S. Dejean, Matteo Iannacone, Francisco J. Quintana, Ari Waisman, Florent Ginhoux, Thomas Korn, Burkhard Becher
Published in: Nature Immunology, 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-01009-w

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