Controlling Cardiomyocyte Dyadic Structure

Project Information

CARDYADS

Grant agreement ID: 647714

DOI 10.3030/647714

Project closed

EC signature date 17 June 2015

Start date 1 July 2015

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

Publications

Peer reviewed articles (21)

Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes

Author(s): Yohannes Shiferaw, Gary L. Aistrup, William E. Louch, J.A. Wasserstrom
Published in: Biophysical Journal, Issue 118/2, 2020, Page(s) 476-491, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2019.12.012

Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis

Author(s): Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR
Published in: Pediatric Cardiology, Issue 41, 2020, Page(s) 1675-1688, ISSN 1432-1971
Publisher: Springer Science+Business Media
DOI: 10.1007/s00246-020-02427-7

Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into Ca 2+ (mis)handling

Author(s): Mary M Maleckar, Andrew G Edwards, William E Louch, Glenn T Lines
Published in: Clinical Medicine Insights: Cardiology, Issue 11, 2017, Page(s) 117954681769860, ISSN 1179-5468
Publisher: Libertas Academica Ltd.
DOI: 10.1177/1179546817698602

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived CardiomyocytesNovelty and Significance

Author(s): Shan S. Parikh, Daniel J. Blackwell, Nieves Gomez-Hurtado, Michael Frisk, Lili Wang, Kyungsoo Kim, Christen P. Dahl, Arnt Fiane, Theis Tønnessen, Dmytro O. Kryshtal, William E. Louch, Bjorn C. Knollmann
Published in: Circulation Research, Issue 121/12, 2017, Page(s) 1323-1330, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.311920

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Author(s): Andrew G Edwards, William E Louch
Published in: Clinical Medicine Insights: Cardiology, Issue 11, 2017, Page(s) 117954681668606, ISSN 1179-5468
Publisher: Libertas Academica Ltd.
DOI: 10.1177/1179546816686061

Compensatory and decompensatory alterations in cardiomyocyte Ca 2+ dynamics in hearts with diastolic dysfunction following aortic banding

Author(s): Sara Gattoni, Åsmund Treu Røe, Jan Magnus Aronsen, Ivar Sjaastad, William E. Louch, Nicolas P. Smith, Steven A. Niederer
Published in: The Journal of Physiology, Issue 595/12, 2017, Page(s) 3867-3889, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/JP273879

T-tubular collagen: a new player in mechanosensing and disease?

Author(s): William E. Louch, Stanley Nattel
Published in: Cardiovascular Research, Issue 113/8, 2017, Page(s) 839-840, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvx091

Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy

Author(s): Ornella Manfra, Michael Frisk, William E. Louch
Published in: Current Heart Failure Reports, Issue 14/3, 2017, Page(s) 167-178, ISSN 1546-9530
Publisher: Current Science Inc.
DOI: 10.1007/s11897-017-0329-9

Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy

Author(s): Åsmund T. Røe, Jan Magnus Aronsen, Kristine Skårdal, Nazha Hamdani, Wolfgang A. Linke, Håvard E. Danielsen, Ole M. Sejersted, Ivar Sjaastad, William E. Louch
Published in: Cardiovascular Research, Issue 113/10, 2017, Page(s) 1161-1172, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvx087

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

Author(s): Michael Frisk, Marianne Ruud, Emil K. S. Espe, Jan Magnus Aronsen, Åsmund T. Røe, Lili Zhang, Per Andreas Norseng, Ole M. Sejersted, Geir A. Christensen, Ivar Sjaastad, William E. Louch
Published in: Cardiovascular Research, Issue 112/1, 2016, Page(s) 443-451, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvw111

Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes

Author(s): Terje R Kolstad, Jonas van den Brink, Niall MacQuaide, Per Kristian Lunde, Michael Frisk, Jan Magnus Aronsen, Einar S Norden, Alessandro Cataliotti, Ivar Sjaastad, Ole M Sejersted, Andrew G Edwards, Glenn Terje Lines, William E Louch
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.39427

Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses

Author(s): Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E. Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-49791-w

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

Author(s): Åsmund T Røe, Marianne Ruud, Emil K Espe, Ornella Manfra, Stefano Longobardi, Jan M Aronsen, Einar Sjaastad Nordén, Trygve Husebye, Terje R S Kolstad, Alessandro Cataliotti, Geir Christensen, Ole M Sejersted, Steven A Niederer, Geir Øystein Andersen, Ivar Sjaastad, William E Louch
Published in: Cardiovascular Research, Issue 115/4, 2018, Page(s) 752-764, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy257

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes

Author(s): Xin Shen, Jonas den Brink, Yufeng Hou, Dylan Colli, Christopher Le, Terje R. Kolstad, Niall MacQuaide, Cathrine R. Carlson, Peter M. Kekenes‐Huskey, Andrew G. Edwards, Christian Soeller, William E. Louch
Published in: The Journal of Physiology, Issue 597/2, 2018, Page(s) 399-418, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/JP277360

Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca 2+ -Dependent Arrhythmia

Author(s): Anett H. Ottesen, Cathrine R. Carlson, Olav Søvik Eken, Mani Sadredini, Peder L. Myhre, Xin Shen, Bjørn Dalhus, Derek R. Laver, Per Kristian Lunde, Jouni Kurola, Marianne Lunde, Jon Erik Hoff, Kristin Godang, Ivar Sjaastad, Ville Pettilä, Mats Stridsberg, Stephan E. Lehnart, Andrew G. Edwards, Ida G. Lunde, Torbjørn Omland, Mathis K. Stokke, Geir Christensen, Helge Røsjø, William E. Louch
Published in: Circulation: Arrhythmia and Electrophysiology, Issue 12/4, 2019, ISSN 1941-3149
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCEP.118.007045

Channel surfing: new insights into plasticity of excitation‐contraction coupling

Author(s): William E. Louch
Published in: The Journal of Physiology, Issue 597/8, 2019, Page(s) 2119-2120, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp277783

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Author(s): D. B. Lipsett, M. Frisk, J. M. Aronsen, E. S. Nordén, O. R. Buonarati, A. Cataliotti, J. W. Hell, I. Sjaastad, G. Christensen, W. E. Louch
Published in: The Journal of Physiology, Issue 597/7, 2019, Page(s) 1833-1853, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp277273

Dyadic Plasticity in Cardiomyocytes

Author(s): Peter P. Jones, Niall MacQuaide, William E. Louch
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01773

Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Author(s): Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On-tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien
Published in: Molecular Therapy, Issue 26/7, 2018, Page(s) 1644-1659, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.02.012

Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction

Author(s): Michael Frisk, Christopher Le, Xin Shen, Åsmund T. Røe, Yufeng Hou, Ornella Manfra, Gustavo J.J. Silva, Isabelle van Hout, Einar S. Norden, J. Magnus Aronsen, Martin Laasmaa, Emil K.S. Espe, Fouad A. Zouein, Regis R. Lambert, Christen P. Dahl, Ivar Sjaastad, Ida G. Lunde, Sean Coffey, Alessandro Cataliotti, Lars Gullestad, Theis Tønnessen, Peter P. Jones, Raffaele Altara, William E. Louch
Published in: Journal of the American College of Cardiology, Issue 77/4, 2021, Page(s) 405-419, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2020.11.044

Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes

Author(s): Kiarash Tazmini, Michael Frisk, Alexandre Lewalle, Martin Laasmaa, Stefano Morotti, David B. Lipsett, Ornella Manfra, Jonas Skogestad, Jan M. Aronsen, Ole M. Sejersted, Ivar Sjaastad, Andrew G. Edwards, Eleonora Grandi, Steven A. Niederer, Erik Øie, William E. Louch
Published in: Circulation Research, Issue 126/7, 2020, Page(s) 889-906, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315641