Controlling Cardiomyocyte Dyadic Structure

Informazioni relative al progetto

CARDYADS

ID dell’accordo di sovvenzione: 647714

DOI

10.3030/647714

Progetto chiuso

Data della firma CE 17 Giugno 2015

Data di avvio 1 Luglio 2015

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

UNIVERSITETET I OSLO
Norway

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes

Autori: Yohannes Shiferaw, Gary L. Aistrup, William E. Louch, J.A. Wasserstrom
Pubblicato in: Biophysical Journal, Numero 118/2, 2020, Pagina/e 476-491, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2019.12.012

Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis

Autori: Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR
Pubblicato in: Pediatric Cardiology, Numero 41, 2020, Pagina/e 1675-1688, ISSN 1432-1971
Editore: Springer Science+Business Media
DOI: 10.1007/s00246-020-02427-7

Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into Ca 2+ (mis)handling

Autori: Mary M Maleckar, Andrew G Edwards, William E Louch, Glenn T Lines
Pubblicato in: Clinical Medicine Insights: Cardiology, Numero 11, 2017, Pagina/e 117954681769860, ISSN 1179-5468
Editore: Libertas Academica Ltd.
DOI: 10.1177/1179546817698602

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived CardiomyocytesNovelty and Significance

Autori: Shan S. Parikh, Daniel J. Blackwell, Nieves Gomez-Hurtado, Michael Frisk, Lili Wang, Kyungsoo Kim, Christen P. Dahl, Arnt Fiane, Theis Tønnessen, Dmytro O. Kryshtal, William E. Louch, Bjorn C. Knollmann
Pubblicato in: Circulation Research, Numero 121/12, 2017, Pagina/e 1323-1330, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCRESAHA.117.311920

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Autori: Andrew G Edwards, William E Louch
Pubblicato in: Clinical Medicine Insights: Cardiology, Numero 11, 2017, Pagina/e 117954681668606, ISSN 1179-5468
Editore: Libertas Academica Ltd.
DOI: 10.1177/1179546816686061

Compensatory and decompensatory alterations in cardiomyocyte Ca 2+ dynamics in hearts with diastolic dysfunction following aortic banding

Autori: Sara Gattoni, Åsmund Treu Røe, Jan Magnus Aronsen, Ivar Sjaastad, William E. Louch, Nicolas P. Smith, Steven A. Niederer
Pubblicato in: The Journal of Physiology, Numero 595/12, 2017, Pagina/e 3867-3889, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/JP273879

T-tubular collagen: a new player in mechanosensing and disease?

Autori: William E. Louch, Stanley Nattel
Pubblicato in: Cardiovascular Research, Numero 113/8, 2017, Pagina/e 839-840, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx091

Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy

Autori: Ornella Manfra, Michael Frisk, William E. Louch
Pubblicato in: Current Heart Failure Reports, Numero 14/3, 2017, Pagina/e 167-178, ISSN 1546-9530
Editore: Current Science Inc.
DOI: 10.1007/s11897-017-0329-9

Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy

Autori: Åsmund T. Røe, Jan Magnus Aronsen, Kristine Skårdal, Nazha Hamdani, Wolfgang A. Linke, Håvard E. Danielsen, Ole M. Sejersted, Ivar Sjaastad, William E. Louch
Pubblicato in: Cardiovascular Research, Numero 113/10, 2017, Pagina/e 1161-1172, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx087

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

Autori: Michael Frisk, Marianne Ruud, Emil K. S. Espe, Jan Magnus Aronsen, Åsmund T. Røe, Lili Zhang, Per Andreas Norseng, Ole M. Sejersted, Geir A. Christensen, Ivar Sjaastad, William E. Louch
Pubblicato in: Cardiovascular Research, Numero 112/1, 2016, Pagina/e 443-451, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvw111

Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes

Autori: Terje R Kolstad, Jonas van den Brink, Niall MacQuaide, Per Kristian Lunde, Michael Frisk, Jan Magnus Aronsen, Einar S Norden, Alessandro Cataliotti, Ivar Sjaastad, Ole M Sejersted, Andrew G Edwards, Glenn Terje Lines, William E Louch
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.39427

Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses

Autori: Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E. Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-49791-w

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

Autori: Åsmund T Røe, Marianne Ruud, Emil K Espe, Ornella Manfra, Stefano Longobardi, Jan M Aronsen, Einar Sjaastad Nordén, Trygve Husebye, Terje R S Kolstad, Alessandro Cataliotti, Geir Christensen, Ole M Sejersted, Steven A Niederer, Geir Øystein Andersen, Ivar Sjaastad, William E Louch
Pubblicato in: Cardiovascular Research, Numero 115/4, 2018, Pagina/e 752-764, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvy257

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes

Autori: Xin Shen, Jonas den Brink, Yufeng Hou, Dylan Colli, Christopher Le, Terje R. Kolstad, Niall MacQuaide, Cathrine R. Carlson, Peter M. Kekenes‐Huskey, Andrew G. Edwards, Christian Soeller, William E. Louch
Pubblicato in: The Journal of Physiology, Numero 597/2, 2018, Pagina/e 399-418, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/JP277360

Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca 2+ -Dependent Arrhythmia

Autori: Anett H. Ottesen, Cathrine R. Carlson, Olav Søvik Eken, Mani Sadredini, Peder L. Myhre, Xin Shen, Bjørn Dalhus, Derek R. Laver, Per Kristian Lunde, Jouni Kurola, Marianne Lunde, Jon Erik Hoff, Kristin Godang, Ivar Sjaastad, Ville Pettilä, Mats Stridsberg, Stephan E. Lehnart, Andrew G. Edwards, Ida G. Lunde, Torbjørn Omland, Mathis K. Stokke, Geir Christensen, Helge Røsjø, William E. Louch
Pubblicato in: Circulation: Arrhythmia and Electrophysiology, Numero 12/4, 2019, ISSN 1941-3149
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCEP.118.007045

Channel surfing: new insights into plasticity of excitation‐contraction coupling

Autori: William E. Louch
Pubblicato in: The Journal of Physiology, Numero 597/8, 2019, Pagina/e 2119-2120, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp277783

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Autori: D. B. Lipsett, M. Frisk, J. M. Aronsen, E. S. Nordén, O. R. Buonarati, A. Cataliotti, J. W. Hell, I. Sjaastad, G. Christensen, W. E. Louch
Pubblicato in: The Journal of Physiology, Numero 597/7, 2019, Pagina/e 1833-1853, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp277273

Dyadic Plasticity in Cardiomyocytes

Autori: Peter P. Jones, Niall MacQuaide, William E. Louch
Pubblicato in: Frontiers in Physiology, Numero 9, 2018, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01773

Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Autori: Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On-tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien
Pubblicato in: Molecular Therapy, Numero 26/7, 2018, Pagina/e 1644-1659, ISSN 1525-0016
Editore: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.02.012

Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction

Autori: Michael Frisk, Christopher Le, Xin Shen, Åsmund T. Røe, Yufeng Hou, Ornella Manfra, Gustavo J.J. Silva, Isabelle van Hout, Einar S. Norden, J. Magnus Aronsen, Martin Laasmaa, Emil K.S. Espe, Fouad A. Zouein, Regis R. Lambert, Christen P. Dahl, Ivar Sjaastad, Ida G. Lunde, Sean Coffey, Alessandro Cataliotti, Lars Gullestad, Theis Tønnessen, Peter P. Jones, Raffaele Altara, William E. Louch
Pubblicato in: Journal of the American College of Cardiology, Numero 77/4, 2021, Pagina/e 405-419, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2020.11.044

Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes

Autori: Kiarash Tazmini, Michael Frisk, Alexandre Lewalle, Martin Laasmaa, Stefano Morotti, David B. Lipsett, Ornella Manfra, Jonas Skogestad, Jan M. Aronsen, Ole M. Sejersted, Ivar Sjaastad, Andrew G. Edwards, Eleonora Grandi, Steven A. Niederer, Erik Øie, William E. Louch
Pubblicato in: Circulation Research, Numero 126/7, 2020, Pagina/e 889-906, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315641