Molecular mechanisms of induced protection against sepsis by DNA damage responses

Project Information

iPROTECTION

Grant agreement ID: 647888

DOI 10.3030/647888

Project closed

EC signature date 31 August 2015

Start date 1 October 2015

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 985 375,00

EU contribution € 1 985 375,00

Coordinated by

FUNDACAO CALOUSTE GULBENKIAN
Portugal

Publications

Other (1)

DNA damage independent inhibition of NF-κB transcription by anthracyclines

Author(s): Angelo Chora, Dora Pedroso, Nadja Pejanovic, Eleni Kyriakou, Henrique Colaço, Raffaella Gozzelino, André Barros, Katharina Willmann, Tiago Velho, Catarina F. Moita, Isa Santos, Pedro Pereira, Sílvia Carvalho, Filipa Martins, João A. Ferreira, Sérgio Fernandes de Almeida, Vladimir Benes, Josef Anrather, Miguel P. Soares, Arie Geerlof, Jacques Neefjes, Michael Sattler, Ana C. Messias, Ana Neves
Published in: BioRxiv, 2019
Publisher: BioRxiv
DOI: 10.1101/2020.04.27.065003

Peer reviewed articles (9)

Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection

Author(s): Henrique G. Colaço, André Barros, Ana Neves-Costa, Elsa Seixas, Dora Pedroso, Tiago Velho, Katharina L. Willmann, Pedro Faisca, Gerlinde Grabmann, Hyon-Seung Yi, Minho Shong, Vladimir Benes, Sebastian Weis, Thomas Köcher, Luís F. Moita
Published in: Immunity, Issue 54/1, 2021, Page(s) 53-67.e7, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.09.011

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus

Author(s): Mohd Hafeez Faridi, Samia Q. Khan, Wenpu Zhao, Ha Won Lee, Mehmet M. Altintas, Kun Zhang, Vinay Kumar, Andrew R. Armstrong, Carmelo Carmona-Rivera, Jessica M. Dorschner, Abigail M. Schnaith, Xiaobo Li, Yogita Ghodke-Puranik, Erica Moore, Monica Purmalek, Jorge Irizarry-Caro, Tingting Zhang, Rachael Day, Darren Stoub, Victoria Hoffmann, Shehryar Jehangir Khaliqdina, Prachal Bhargava, Ana M. Santand
Published in: Journal of Clinical Investigation, Issue 127/4, 2017, Page(s) 1271-1283, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci88442

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

Author(s): Susana A. Gonçalves, Diana Macedo, Helena Raquel, Pedro D. Simões, Flaviano Giorgini, José S. Ramalho, Duarte C. Barral, Luís Ferreira Moita, Tiago Fleming Outeiro
Published in: PLOS Genetics, Issue 12/4, 2016, Page(s) e1005995, ISSN 1553-7404
Publisher: PLoS
DOI: 10.1371/journal.pgen.1005995

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

Author(s): Luís Almeida, Ayesha Dhillon-LaBrooy, Carla N. Castro, Nigatu Adossa, Guilhermina M. Carriche, Melanie Guderian, Saskia Lippens, Sven Dennerlein, Christina Hesse, Bart N. Lambrecht, Luciana Berod, Leif Schauser, Bruce R. Blazar, Markus Kalesse, Rolf Müller, Luís F. Moita, Tim Sparwasser
Published in: Immunity, Issue 54/1, 2021, Page(s) 68-83.e6, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.11.001

Sepsis: the need for tolerance not complacency

Author(s): TR Velho, I Santos, P Póvoa, Moita Ferreira
Published in: Swiss Medical Weekly, 2016, ISSN 1424-7860
Publisher: EMH Swiss Medical Publishers Ltd
DOI: 10.4414/smw.2016.14276

Initiation of innate immune responses by surveillance of homeostasis perturbations

Author(s): Henrique G. Colaço, Luis F. Moita
Published in: The FEBS Journal, Issue 283/13, 2016, Page(s) 2448-2457, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.13730

Disease tolerance and immunity in host protection against infection

Author(s): Miguel P. Soares, Luis Teixeira, Luis F. Moita
Published in: Nature Reviews Immunology, Issue 17/2, 2017, Page(s) 83-96, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2016.136

Modulation of inflammation and disease tolerance by DNA damage response pathways

Author(s): Ana Neves-Costa, Luis F. Moita
Published in: The FEBS Journal, Issue 284/5, 2017, Page(s) 680-698, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.13910

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Author(s): Marina Badenes, Abdulbasit Amin, Ismael González-García, Inês Félix, Emma Burbridge, Miguel Cavadas, Francisco José Ortega, Érika de Carvalho, Pedro Faísca, Stefania Carobbio, Elsa Seixas, Dora Pedroso, Ana Neves-Costa, Luís F. Moita, José Manuel Fernández-Real, António Vidal-Puig, Ana Domingos, Miguel López, Colin Adrain
Published in: Molecular Metabolism, Issue 31, 2020, Page(s) 67-84, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.10.006

Non-peer reviewed articles (1)

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis

Author(s): Isa Santos, Henrique G Colaço, Ana Neves-Costa, Elsa Seixas, Tiago R Velho, Dora Pedroso, André Barros, Rui Martins, Sebastian Weiss, Didier Payen, Sebastian Weiss, Hyon-Seung Yi, Minho Shong, Luis F Moita
Published in: Proc Natl Acad Sci U S A, 2020, ISSN 1091-6490
Publisher: Proc Natl Acad Sci U S A
DOI: 10.1101/613901

Intellectual Property Rights

Patent (3)

AN ANTHRACYCLINE FOR THE TREATMENT OF SEPSIS

Application/Publication number: EP 12780554
Date: 2012-09-07

AN ANTHRACYCLINE FOR THE TREATMENT OF SEPSIS

Application/Publication number: EP 12780554
Date: 2012-09-07

AN ANTHRACYCLINE FOR THE TREATMENT OF SEPSIS

Application/Publication number: EP 12780554
Date: 2012-09-07