Functions of the X chromosome in the mammalian germ line

Project Information

XChromosome

Grant agreement ID: 647971

DOI

10.3030/647971

Project closed

EC signature date 26 August 2015

Start date 1 November 2015

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 912 369,00

EU contribution

€ 1 912 369,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

Author(s): Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis & James M. A. Turner
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27227-2

A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation

Author(s): Shantha K. Mahadevaiah, Mahesh N. Sangrithi, Takayuki Hirota, James M. A. Turner
Published in: Nature, Issue 586/7830, 2020, Page(s) 612-617, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2629-6

Epigenetics drive the evolution of sex chromosomes in animals and plants

Author(s): Aline Muyle, Doris Bachtrog, Gabriel A. B. Marais, James M. A. Turner
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 376/1826, 2021, Page(s) 20200124, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2020.0124

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Author(s): Gregorio Alanis-Lobato, Jasmin Zohren, Afshan McCarthy, Norah M. E. Fogarty, Nada Kubikova, Emily Hardman, Maria Greco, Dagan Wells, James M. A. Turner, Kathy K. Niakan
Published in: Proceedings of the National Academy of Sciences, Issue 118/22, 2021, Page(s) e2004832117, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2004832117

Human Embryogenesis: A Comparative Perspective

Author(s): Claudia Gerri, Sergio Menchero, Shantha K. Mahadevaiah, James M.A. Turner, Kathy K. Niakan
Published in: Annual Review of Cell and Developmental Biology, Issue 36/1, 2020, Page(s) 411-440, ISSN 1081-0706
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-022020-024900

DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Author(s): Elias ElInati, Helen R. Russell, Obah A. Ojarikre, Mahesh Sangrithi, Takayuki Hirota, Dirk G. de Rooij, Peter J. McKinnon, James M. A. Turner
Published in: Proceedings of the National Academy of Sciences, Issue 114/47, 2017, Page(s) 12536-12541, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1712530114

Fertile offspring from sterile sex chromosome trisomic mice

Author(s): Takayuki Hirota, Hiroshi Ohta, Benjamin E. Powell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Mitinori Saitou, James M. A. Turner
Published in: Science, Issue 357/6354, 2017, Page(s) 932-935, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aam9046

Mammalian X Chromosome Dosage Compensation: Perspectives From the Germ Line

Author(s): Mahesh N. Sangrithi, James M. A. Turner
Published in: BioEssays, Issue 40/6, 2018, Page(s) 1800024, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201800024

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

Author(s): Takayuki Hirota, Paul Blakeley, Mahesh N. Sangrithi, Shantha K. Mahadevaiah, Vesela Encheva, Ambrosius P. Snijders, Elias ElInati, Obah A. Ojarikre, Dirk G. de Rooij, Kathy K. Niakan, James M.A. Turner
Published in: Developmental Cell, Issue 47/5, 2018, Page(s) 645-659.e6, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2018.10.004

Meiotic Silencing in Mammals

Author(s): James M.A. Turner
Published in: Annual Review of Genetics, Issue 49/1, 2015, Page(s) 395-412, ISSN 0066-4197
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genet-112414-055145

Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline

Author(s): Mahesh N. Sangrithi, Helene Royo, Shantha K. Mahadevaiah, Obah Ojarikre, Leena Bhaw, Abdul Sesay, Antoine H.F.M. Peters, Michael Stadler, James M.A. Turner
Published in: Developmental Cell, Issue 40/3, 2017, Page(s) 289-301.e3, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2016.12.023

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Author(s): Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16441-z

ATR is a multifunctional regulator of male mouse meiosis

Author(s): Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04850-0

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Author(s): Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale, Ganka Bineva-Todd, Dhruva Biswas, Richard Byrne, Simon Caidan, Peter Cherepanov, Laura Churchward, Graham Clark, Margaret Crawford, Laura Cubitt, Vicky Dearing, Christopher Earl, Amelia Edwards, Chris Ekin, Efthymios Fidanis, Alessandra Gaiba, Steve Gamblin, Sonia Gandhi, Jacki Goldman, Robert Goldstone, Paul R. Grant, Maria Greco, Judith Heane
Published in: Nature Biotechnology, Issue 38/8, 2020, Page(s) 1000-1000, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-0623-z