Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing

Project Information

Drug-Seq

Grant agreement ID: 647973

DOI

10.3030/647973

Project closed

EC signature date 20 July 2015

Start date 1 September 2015

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 900,00

EU contribution

€ 1 999 900,00

Coordinated by

INSTITUT CURIE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Expeditive Synthesis of Potent C20-<i>epi</i>-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells

Author(s): Dominika Czerwonka; Sebastian Müller; Tatiana Cañeque; Ludovic Colombeau; Adam Huczyński; Michał Antoszczak; Raphaël Rodriguez
Published in: ACS Organic & Inorganic Au, Issue 8, 2022, ISSN 2694-247X
Publisher: ACS
DOI: 10.1021/acsorginorgau.1c00046

CD44 regulates cellular plasticity by mediating iron endocytosis

Author(s): S. Müller, F. Sindikubwabo, T. Cañeque, A. Lafon, A. Versini, C. Ginestier, E. Charafe-Jauffret, B. Lombard, D. Loew, T.-D. Wu, A. Durand, C. Vallot, S. Baulande, N. Servant, R. Rodriguez*
Published in: Nature Chemistry, 2020, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-0513-5

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

Author(s): S. Garciaz*, A. A. Guirguis, S. Müller, F. C. Brown, Y.-C. Chan, A. Motazedian, C. L. Rowe, J. A. Kuzich, K. L. Chan, K. Tran, L. Smith, L. MacPherson, B. Liddicoat, E. Y. N. Lam, T. Cañeque, M. L. Burr, V. Litalien, G. Pomilio, M. Poplineau, E. Duprez, S.-J. Dawson, G. Ramm, A. G. Cox, K. K. Brown, D. C. S. Huang, A. H. Wei, K. McArthur, R. Rodriguez*, M. A. Dawson*
Published in: Cancer Discovey, 2022, ISSN 2159-8290
Publisher: AACR
DOI: 10.1158/2159-8290.cd-21-0522

Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells

Author(s): Müller, Sebastian; Versini, Antoine; Sindikubwabo, Fabien; Belthier, Guillaume; Niyomchon, Supaporn; Pannequin, Julie; Grimaud, Laurence; Cañeque, Tatiana; Rodriguez, Raphaël
Published in: PLoS ONE, Issue 2, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0206764

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

Author(s): Julie Devin; Tatiana Cañeque; Yea-Lih Lin; Lucie Mondoulet; Jean-Luc Veyrune; Matthieu Abouladze; Elvira Garcia De Paco; Ouissem Karmous Gadacha; Guillaume Cartron; Philippe Pasero; Caroline Bret; Raphaël Rodriguez; Jerome Moreaux
Published in: Cancer Research, Issue 1, 2022, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-0218

HNF1a acts as a tumor suppressor in steatosis-associated liver cancer by repressing PPARg

Author(s): C. Patitucci, G. Couchy, A. Bagattin, T. Cañeque, A. de Reynies, J.-Y. Scoazec, R. Rodriguez, M. Pontoglio, J. Zucman-Rossi, M. Pende, G. Panasyuk
Published in: Journal of Clinical Investigation, 2017, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci90327

Image-based morphological profiling identifies a lysosomotropic, iron-sequestering autophagy inhibitor

Author(s): Laraia, Luca; Garivet, Guillaume; Foley, Daniel J.; Kaiser, Nadine; Müller, Sebastian; Zinken, Sarah; Pinkert, Thomas; Wilke, Julian; Corkery, Dale; Pahl, Axel; Sievers, Sonja; Janning, Petra; Arenz, Christoph; Wu, Yaowen; Rodriguez, Raphaël; Waldmann, Herbert
Published in: Angewandte Chemie International Edition, Issue 18, 2020, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201913712

Loss of SDHB promotes dysregulated iron homeostasis, oxidative stress and sensitivity to ascorbate

Author(s): J. Goncalves, S. Moog, A. Morin, G. Gentric, S. Müller, A. P. Morrell, K. Kluckova, T. J. Stewart, C. L. Andoniadou, C. Lussey-Lepoutre, P. Benit, A. Thakker, L. Vettore, J. Roberts, R. Rodriguez, F. Mechta-Grigoriou, A.-P. Gimenez-Roqueplo, E. Letouze, D. A. Tennant, J. Favier
Published in: Cancer Research, 2021, ISSN 1538-7445
Publisher: AACR
DOI: 10.1158/0008-5472.can-20-2936

An iron hand over cancer stem cells

Author(s): A. Hamaï, T. Cañeque, S. Müller, T. T. Mai, A. Hienzsch, C. Ginestier, E. Charafe-Jauffret, P. Codogno, M. Mehrpour, R. Rodriguez
Published in: Autophagy, 2017, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2017.1327104

Chemistry and biology of ferritin.

Author(s): Marina Plays; Sebastian Müller; Raphaël Rodriguez
Published in: Metallomics, Issue 3, 2021, ISSN 1756-5901
Publisher: Royal Society of Chemistry
DOI: 10.1093/mtomcs/mfab021

Visualizing biologically active small molecules in cells using click chemistry

Author(s): T. Cañeque, S. Müller, R. Rodriguez
Published in: Nature Reviews Chemistry, 2018, ISSN 2397-3358
Publisher: Springer Nature
DOI: 10.1038/s41570-018-0030-x

Chemical biology of salinomycin

Author(s): Antoine Versini; Lou Saier; Fabien Sindikubwabo; Sebastian Müller; Tatiana Cañeque; Raphaël Rodriguez
Published in: Tetrahedron, Issue 5, 2018, ISSN 0040-4020
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2018.07.028

Reprogramming the chemical reactivity of iron in cancer stem cells

Author(s): Cañeque, Tatiana; Müller, Sebastian; Lafon, Anne; Sindikubwabo, Fabien; Versini, Antoine; Saier, Lou; Barutaut, Manon; Gaillet, Christine; Rodriguez, Raphaël
Published in: Comptes Rendus Chimie, Issue 10, 2018, ISSN 1631-0748
Publisher: Elsevier Masson
DOI: 10.1016/j.crci.2018.03.012

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Author(s): Gentric, Géraldine; Kieffer, Yann; Mieulet, Virginie; Goundiam, Oumou; Bonneau, Claire; Némati, Fariba; Hurbain, Ilse; Raposo, Graça; Popova, Tatiana; Stern, Marc-Henri; Lallemand-Breitenbach, Valérie; Müller, Sebastian; Cañeque, Tatiana; Rodriguez, Raphaël; Vincent-Salomon, Anne; de Thé, Hugues; Rossignol, Rodrigue; Mechta-Grigoriou, Fatima
Published in: Cell Metabolism, Issue 17, 2019, ISSN 1932-7420
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.09.002

Chromatin Regulates Genome Targeting with Cisplatin

Author(s): Emmanouil Zacharioudakis, Poonam Agarwal, Alexandra Bartoli, Nathan Abell, Lavaniya Kunalingam, Valérie Bergoglio, Blerta Xhemalce, Kyle M. Miller, Raphaël Rodriguez
Published in: Angewandte Chemie International Edition, Issue 56/23, 2017, Page(s) 6483-6487, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201701144

Click chemistry enables preclinical evaluation of targeted epigenetic therapies

Author(s): Dean S. Tyler, Johanna Vappiani, Tatiana Cañeque, Enid Y. N. Lam, Aoife Ward, Omer Gilan, Yih-Chih Chan, Antje Hienzsch, Anna Rutkowska, Thilo Werner, Anne J. Wagner, Dave Lugo, Richard Gregory, Cesar Ramirez Molina, Neil Garton, Christopher R. Wellaway, Susan Jackson, Laura MacPherson, Margarida Figueiredo, Sabine Stolzenburg, Charles C. Bell, Colin House, Sarah-Jane Dawson, Edwin D. Hawkins, Ge
Published in: Science, Issue 356/6345, 2017, Page(s) 1397-1401, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aal2066

Synthesis of marmycin A and investigation into its cellular activity

Author(s): Tatiana Cañeque, Filipe Gomes, Trang Thi Mai, Giovanni Maestri, Max Malacria, Raphaël Rodriguez
Published in: Nature Chemistry, Issue 7/9, 2015, Page(s) 744-751, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/NCHEM.2302

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Author(s): Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski, Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe Ginestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour, Raphaël Rodriguez
Published in: Nature Chemistry, Issue 9/10, 2017, Page(s) 1025-1033, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/NCHEM.2778

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Author(s): Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, David J. Adams, Stephen P. Jackson
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03770-3

Persister cancer cells: iron addiction and vulnerability to ferroptosis

Author(s): R. Rodriguez*, S. L. Schreiber*, M. Conrad*
Published in: Molecular Cell, 2022, ISSN 1097-4164
Publisher: Elsevier
DOI: 10.1016/j.molcel.2021.12.001

Rapid Access to Ironomycin Derivatives by Click Chemistry

Author(s): Michał Antoszczak; Sebastian Müller; Ludovic Colombeau; Tatiana Cañeque; Raphaël Rodriguez
Published in: ACS Organic & Inorganic Au, Issue 9, 2022, ISSN 2694-247X
Publisher: ACS
DOI: 10.1021/acsorginorgau.1c00045

Small Molecule Inhibitors of Interferon-Induced JAK-STAT Signalling

Author(s): L. K. Thoidingjam, C. M. Blouin, C. Gaillet, A. Brion, S. Solier, S. Niyomchon, A. El Marjou, S. Mouasni, F. E. Sepulveda, G. de Saint Basile, C. Lamaze, R. Rodriguez
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202205231