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Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis.

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Publications

NOTCH1 mediates a switch between two distinct secretomes during senescence

Author(s): Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael P. Weekes, Nicholas J. Matheson, Daniel A. Patten, Shishir Shetty, Aled J. Parry, Suraj Menon, Rafik Salama, Robin Antrobus, Kosuke Tomimatsu, William Howat, Paul J. Lehner, Lars Zender, Masashi Narita
Published in: Nature Cell Biology, 18/9, 2016, Page(s) 979-992, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3397

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Author(s): Iván M. Moya, Stéphanie A. Castaldo, Laura Van den Mooter, Soheil Soheily, Leticia Sansores-Garcia, Jelle Jacobs, Inge Mannaerts, Jun Xie, Elisabeth Verboven, Hanne Hillen, Ana Algueró-Nadal, Ruchan Karaman, Matthias Van Haele, Weronika Kowalczyk, Maxime De Waegeneer, Stefaan Verhulst, Panagiotis Karras, Leen van Huffel, Lars Zender, Jean-Christophe Marine, Tania Roskams, Randy Johnson, Stein A
Published in: Science, 366/6468, 2019, Page(s) 1029-1034, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw9886

Cardiac glycosides are broad-spectrum senolytics

Author(s): Ana Guerrero, Nicolás Herranz, Bin Sun, Verena Wagner, Suchira Gallage, Romain Guiho, Katharina Wolter, Joaquim Pombo, Elaine E. Irvine, Andrew J. Innes, Jodie Birch, Justyna Glegola, Saba Manshaei, Danijela Heide, Gopuraja Dharmalingam, Jule Harbig, Antoni Olona, Jacques Behmoaras, Daniel Dauch, Anthony G. Uren, Lars Zender, Santiago Vernia, Juan Pedro Martínez-Barbera, Mathias Heikenwalder, Do
Published in: Nature Metabolism, 1/11, 2019, Page(s) 1074-1088, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-019-0122-z

Therapy-induced senescence — an induced synthetic lethality in liver cancer?

Author(s): Katharina Wolter, Lars Zender
Published in: Nature Reviews Gastroenterology & Hepatology, 17/3, 2020, Page(s) 135-136, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-020-0262-3

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Author(s): Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Published in: Nature Medicine, 25/4, 2019, Page(s) 641-655, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0379-5

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

Author(s): Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender, Christoph Borner
Published in: Cell Death & Disease, 9/9, 2018, Page(s) n/a, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-018-0935-9

Necroptosis microenvironment directs lineage commitment in liver cancer

Author(s): Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof, Lars Zender
Published in: Nature, 562/7725, 2018, Page(s) 69-75, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0519-y

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Author(s): Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser
Published in: Nature Cell Biology, 19/9, 2017, Page(s) 1061-1070, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/ncb3586

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

Author(s): Tobias Eggert, Katharina Wolter, Juling Ji, Chi Ma, Tetyana Yevsa, Sabrina Klotz, José Medina-Echeverz, Thomas Longerich, Marshonna Forgues, Florian Reisinger, Mathias Heikenwalder, Xin Wei Wang, Lars Zender, Tim F. Greten
Published in: Cancer Cell, 30/4, 2016, Page(s) 533-547, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2016.09.003