Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis.

Pubblicazioni

NOTCH1 mediates a switch between two distinct secretomes during senescence

Autori: Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael P. Weekes, Nicholas J. Matheson, Daniel A. Patten, Shishir Shetty, Aled J. Parry, Suraj Menon, Rafik Salama, Robin Antrobus, Kosuke Tomimatsu, William Howat, Paul J. Lehner, Lars Zender, Masashi Narita
Pubblicato in: Nature Cell Biology, Numero 18/9, 2016, Pagina/e 979-992, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/ncb3397

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Autori: Iván M. Moya, Stéphanie A. Castaldo, Laura Van den Mooter, Soheil Soheily, Leticia Sansores-Garcia, Jelle Jacobs, Inge Mannaerts, Jun Xie, Elisabeth Verboven, Hanne Hillen, Ana Algueró-Nadal, Ruchan Karaman, Matthias Van Haele, Weronika Kowalczyk, Maxime De Waegeneer, Stefaan Verhulst, Panagiotis Karras, Leen van Huffel, Lars Zender, Jean-Christophe Marine, Tania Roskams, Randy Johnson, Stein A
Pubblicato in: Science, Numero 366/6468, 2019, Pagina/e 1029-1034, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aaw9886

Cardiac glycosides are broad-spectrum senolytics

Autori: Ana Guerrero, Nicolás Herranz, Bin Sun, Verena Wagner, Suchira Gallage, Romain Guiho, Katharina Wolter, Joaquim Pombo, Elaine E. Irvine, Andrew J. Innes, Jodie Birch, Justyna Glegola, Saba Manshaei, Danijela Heide, Gopuraja Dharmalingam, Jule Harbig, Antoni Olona, Jacques Behmoaras, Daniel Dauch, Anthony G. Uren, Lars Zender, Santiago Vernia, Juan Pedro Martínez-Barbera, Mathias Heikenwalder, Do
Pubblicato in: Nature Metabolism, Numero 1/11, 2019, Pagina/e 1074-1088, ISSN 2522-5812
Editore: Nature Publishing Group
DOI: 10.1038/s42255-019-0122-z

Therapy-induced senescence — an induced synthetic lethality in liver cancer?

Autori: Katharina Wolter, Lars Zender
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, Numero 17/3, 2020, Pagina/e 135-136, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-020-0262-3

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Autori: Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr
Pubblicato in: Nature Medicine, Numero 25/4, 2019, Pagina/e 641-655, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-019-0379-5

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

Autori: Laura Faletti, Lukas Peintner, Simon Neumann, Sandra Sandler, Thomas Grabinger, Sabine Mac Nelly, Irmgard Merfort, Chun-Hao Huang, Darjus Tschaharganeh, Tae-Won Kang, Florian Heinzmann, Luana D’Artista, Ulrich Maurer, Thomas Brunner, Scott Lowe, Lars Zender, Christoph Borner
Pubblicato in: Cell Death & Disease, Numero 9/9, 2018, Pagina/e n/a, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0935-9

Necroptosis microenvironment directs lineage commitment in liver cancer

Autori: Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof, Lars Zender
Pubblicato in: Nature, Numero 562/7725, 2018, Pagina/e 69-75, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0519-y

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Autori: Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser
Pubblicato in: Nature Cell Biology, Numero 19/9, 2017, Pagina/e 1061-1070, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/ncb3586

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

Autori: Tobias Eggert, Katharina Wolter, Juling Ji, Chi Ma, Tetyana Yevsa, Sabrina Klotz, José Medina-Echeverz, Thomas Longerich, Marshonna Forgues, Florian Reisinger, Mathias Heikenwalder, Xin Wei Wang, Lars Zender, Tim F. Greten
Pubblicato in: Cancer Cell, Numero 30/4, 2016, Pagina/e 533-547, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2016.09.003

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