Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging

Project Information

MMAF

Grant agreement ID: 648131

DOI 10.3030/648131

Project closed

EC signature date 15 October 2015

Start date 1 January 2016

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 305,00

EU contribution € 1 999 305,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publications

Peer reviewed articles (23)

Multi-ethnic genome-wide association study for atrial fibrillation

Author(s): Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Ca
Published in: Nature Genetics, 2018, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0133-9

Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women – results from the FINRISK study

Author(s): Tanja Zeller, Renate B Schnabel, Sebastian Appelbaum, Francisco Ojeda, Filip Berisha, Benedict Schulte-Steinberg, Burkhard-Ekkehart Brueckmann, Kari Kuulasmaa, Pekka Jousilahti, Stefan Blankenberg, Tarja Palosaari, Veikko Salomaa, Mahir Karakas
Published in: European Journal of Preventive Cardiology, Issue 25/11, 2018, Page(s) 1133-1139, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1177/2047487318778346

Sex and Stroke Risk in Atrial Fibrillation

Author(s): Renate B. Schnabel, Emelia J. Benjamin
Published in: JACC: Clinical Electrophysiology, Issue 4/5, 2018, Page(s) 615-617, ISSN 2405-500X
Publisher: elsevier
DOI: 10.1016/j.jacep.2018.03.002

Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe

Author(s): Renate B. Schnabel, Ladislav Pecen, Nargiz Rzayeva, Markus Lucerna, Yanish Purmah, Francisco M. Ojeda, Raffaele De Caterina, Paulus Kirchhof
Published in: Journal of the American Heart Association, Issue 7/11, 2018, Page(s) e007559, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/JAHA.117.007559

Response by Magnussen et al to Letter Regarding Article, “Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)”

Author(s): Christina Magnussen, Francisco M. Ojeda, Renate B. Schnabel
Published in: Circulation, Issue 137/19, 2018, Page(s) 2087-2088, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.118.033968

Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy

Author(s): Jolanta M. Siller-Matula, Ladislav Pecen, Giuseppe Patti, Markus Lucerna, Paulus Kirchhof, Maciej Lesiak, Kurt Huber, Freek W.A. Verheugt, Irene M. Lang, Giulia Renda, Renate B. Schnabel, Rolf Wachter, Dipak Kotecha, Jean-Marc Sellal, Miklos Rohla, Fabrizio Ricci, Raffaele De Caterina
Published in: International Journal of Cardiology, Issue 265, 2018, Page(s) 141-147, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2018.04.093

Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)

Author(s): Christina Magnussen, Francisco M. Ojeda, Philipp S. Wild, Nils Sörensen, Thomas Rostock, Boris A. Hoffmann, Jürgen Prochaska, Karl J. Lackner, Manfred E. Beutel, Maria Blettner, Norbert Pfeiffer, Nargiz Rzayeva, Christoph R. Sinning, Stefan Blankenberg, Thomas Münzel, Tanja Zeller, Renate B. Schnabel
Published in: The American Journal of Cardiology, Issue 122/1, 2018, Page(s) 76-82, ISSN 0002-9149
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2018.03.028

Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome

Author(s): Nils Arne Sörensen, Johannes Tobias Neumann, Francisco Ojeda, Sarina Schäfer, Christina Magnussen, Till Keller, Karl J. Lackner, Tanja Zeller, Mahir Karakas, Thomas Münzel, Stefan Blankenberg, Dirk Westermann, Renate B. Schnabel
Published in: Journal of the American Heart Association, Issue 7/6, 2018, Page(s) e007297, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/JAHA.117.007297

Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support

Author(s): Christina Magnussen, Alexander M. Bernhardt, Francisco M. Ojeda, Florian M. Wagner, Jan Gummert, Theo M.M.H. de By, Thomas Krabatsch, Paul Mohacsi, Meike Rybczynski, Dorit Knappe, Bjoern Sill, Tobias Deuse, Stefan Blankenberg, Renate B. Schnabel, Hermann Reichenspurner
Published in: The Journal of Heart and Lung Transplantation, Issue 37/1, 2018, Page(s) 61-70, ISSN 1053-2498
Publisher: Elsevier BV
DOI: 10.1016/j.healun.2017.06.016

The Changing Landscape of Atrial Fibrillation

Author(s): Darae Ko, Renate B. Schnabel, Ludovic Trinquart, Emelia J. Benjamin
Published in: JACC: Heart Failure, Issue 5/8, 2017, Page(s) 561-564, ISSN 2213-1779
Publisher: Elsevier BV
DOI: 10.1016/j.jchf.2017.05.002

Screening for Atrial Fibrillation

Author(s): Ben Freedman, John Camm, Hugh Calkins, Jeffrey S. Healey, Mårten Rosenqvist, Jiguang Wang, Christine M. Albert, Craig S. Anderson, Sotiris Antoniou, Emelia J. Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A. Fitzmaurice, Leif Friberg, Bernard J. Gersh, David J. Gladstone, Taya V. Glotzer, Kylie Gwynne, Graeme J. Han
Published in: Circulation, Issue 135/19, 2017, Page(s) 1851-1867, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.026693

Atrial fibrillation in women: treatment

Author(s): Darae Ko, Faisal Rahman, Maria A. P. Martins, Elaine M. Hylek, Patrick T. Ellinor, Renate B. Schnabel, Emelia J. Benjamin, Ingrid E. Christophersen
Published in: Nature Reviews Cardiology, Issue 14/2, 2017, Page(s) 113-124, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/nrcardio.2016.171

Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)

Author(s): Darae Ko, Eric M. Riles, Ernaldo G. Marcos, Jared W. Magnani, Steven A. Lubitz, Honghuang Lin, Michelle T. Long, Renate B. Schnabel, David D. McManus, Patrick T. Ellinor, Vasan S. Ramachandran, Thomas J. Wang, Robert E. Gerszten, Emelia J. Benjamin, Xiaoyan Yin, Michiel Rienstra
Published in: The American Journal of Cardiology, Issue 118/10, 2016, Page(s) 1493-1496, ISSN 0002-9149
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2016.08.010

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation

Author(s): Renate B. Schnabel, Renke Maas, Na Wang, Xiaoyan Yin, Martin G. Larson, Daniel Levy, Patrick T. Ellinor, Steven A. Lubitz, David D. McManus, Jared W. Magnani, Dorothee Atzler, Rainer H. Böger, Edzard Schwedhelm, Ramachandran S. Vasan, Emelia J. Benjamin
Published in: American Heart Journal, Issue 176, 2016, Page(s) 100-106, ISSN 0002-8703
Publisher: Mosby Inc.
DOI: 10.1016/j.ahj.2016.03.007

Atrial fibrillation in women: epidemiology, pathophysiology, presentation and prognosis

Author(s): Darae Ko, Faisal Rahman, Renate B. Schnabel, Xiaoyan Yin, Emelia J. Benjamin, Ingrid E. Christophersen
Published in: Nature Reviews Cardiology, Issue 13/6, 2016, Page(s) 321-332, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/nrcardio.2016.45

Underrepresentation of sex in reporting traditional and emerging biomarkers for primary prevention of cardiovascular disease: a systematic review

Author(s): Aisha Gohar, Renate B. Schnabel, Maria Hughes, Tanja Zeller, Stefan Blankenberg, Gerard Pasterkamp, Hester den Ruijter
Published in: European Heart Journal - Quality of Care and Clinical Outcomes, Issue 2/2, 2016, Page(s) 99-107, ISSN 2058-5225
Publisher: European Society of Cardiology
DOI: 10.1093/ehjqcco/qcv028

ADMA, subclinical changes and atrial fibrillation in the general population

Author(s): Meike Ramuschkat, Sebastian Appelbaum, Dorothee Atzler, Tanja Zeller, Christoph Bauer, Francisco M. Ojeda, Christoph R. Sinning, Boris Hoffmann, Karl J. Lackner, Rainer H. Böger, Philipp S. Wild, Thomas Münzel, Stefan Blankenberg, Edzard Schwedhelm, Renate B. Schnabel
Published in: International Journal of Cardiology, Issue 203, 2016, Page(s) 640-646, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2015.05.102

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Author(s): Renate B Schnabel, Ladislav Pecen, Daniel Engler, Markus Lucerna, Jean Marc Sellal, Francisco M Ojeda, Raffaele De Caterina, Paulus Kirchhof
Published in: Heart, 2017, Page(s) heartjnl-2017-312569, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2017-312569

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

Author(s): Christina Magnussen, Teemu J. Niiranen, Francisco M. Ojeda, Francesco Gianfagna, Stefan Blankenberg, Inger Njølstad, Erkki Vartiainen, Susana Sans, Gerard Pasterkamp, Maria Hughes, Simona Costanzo, Maria Benedetta Donati, Pekka Jousilahti, Allan Linneberg, Tarja Palosaari, Giovanni de Gaetano, Martin Bobak, Hester M. den Ruijter, Ellisiv Mathiesen, Torben Jørgensen, Stefan Söderberg, Kari Kuula
Published in: Circulation, Issue 136/17, 2017, Page(s) 1588-1597, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.117.028981

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference

Author(s): Paulus Kirchhof, Günter Breithardt, Jeroen Bax, Gerlinde Benninger, Carina Blomstrom-Lundqvist, Giuseppe Boriani, Axel Brandes, Helen Brown, Martina Brueckmann, Hugh Calkins, Melanie Calvert, Vincent Christoffels, Harry Crijns, Dobromir Dobrev, Patrick Ellinor, Larissa Fabritz, Thomas Fetsch, S. Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Guido Hack, Laurent Haegeli, Stephane Hatem
Published in: Europace, Issue 18/1, 2016, Page(s) 37-50, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euv304

Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation

Author(s): Renate B Schnabel, Ladislav Pecen, Francisco M Ojeda, Markus Lucerna, Nargiz Rzayeva, Stefan Blankenberg, Harald Darius, Dipak Kotecha, Raffaele De Caterina, Paulus Kirchhof
Published in: Heart, Issue 103/13, 2017, Page(s) 1024-1030, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-310406

Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community—The Gutenberg Health Study

Author(s): Christoph Niekamp, Dorothee Atzler, Francisco Ojeda, Christoph Sinning, Karl Lackner, Rainer Böger, Thomas Munzel, Manfred Beutel, Irene Schmidtmann, Norbert Pfeiffer, Anja Leuschner, Stefan Blankenberg, Philipp Wild, Tanja Zeller, Edzard Schwedhelm, Renate Schnabel
Published in: Biomolecules, Issue 8/3, 2018, Page(s) 86, ISSN 2218-273X
Publisher: MDPI AG, Basel, Switzerland
DOI: 10.3390/biom8030086

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

Author(s): Francisco M. Ojeda, Christian Müller, Daniela Börnigen, David-Alexandre Trégouët, Arne Schillert, Matthias Heinig, Tanja Zeller, Renate B. Schnabel
Published in: Genomics, Proteomics & Bioinformatics, Issue 14/4, 2016, Page(s) 235-243, ISSN 1672-0229
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2016.03.006