Publications Peer reviewed articles (33) Recombineering and MAGE Author(s): Timothy M. Wannier, Peter N. Ciaccia, Andrew D. Ellington, Gabriel T. Filsinger, Farren J. Isaacs, Kamyab Javanmardi, Michaela A. Jones, Aditya M. Kunjapur, Akos Nyerges, Csaba Pal, Max G. Schubert & George M. Church Published in: Nature Reviews Methods Primers, 2021, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s43586-020-00006-x Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation. Author(s): Martina Durcik; Žiga Skok; Janez Ilaš; Nace Zidar; Anamarija Zega; Petra Szili; Gábor Draskovits; Tamás Révész; Danijel Kikelj; Ákos Nyerges; Ákos Nyerges; Csaba Pál; Lucija Peterlin Mašič; Tihomir Tomašič Published in: Pharmaceutics, volumne 13, chapter 6, Issue 2, 2020, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13010006 CRISPR-interference-based modulation of mobile genetic elements in bacteria Author(s): Ákos Nyerges, Balázs Bálint, Judit Cseklye, István Nagy, Csaba Pál, Tamás Fehér Published in: Synthetic Biology, Issue 4/1, 2019, ISSN 2397-7000 Publisher: Oxford Academic DOI: 10.1093/synbio/ysz008 Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization Author(s): Kaushik Nath Bhaumik; Anasztázia Hetényi; Gábor Olajos; Ana Martins; Réka Spohn; Lukács Németh; Balázs Jójárt; Petra Szili; Petra Szili; Anett Dunai; Pramod Kumar Jangir; Lejla Daruka; Lejla Daruka; Imre Földesi; D Kata; Csaba Pál; Tamás A. Martinek Published in: Molecular Systems Design & Engineering, Issue 2, 2021, ISSN 2058-9689 Publisher: Royal Society of Chemistry DOI: 10.1039/d1me00118c Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast Author(s): Zoltán Farkas, Károly Kovács, Zsuzsa Sarkadi, Dorottya Kalapis, Gergely Fekete, Fanni Birtyik, Ferhan Ayaydin, Csaba Molnár, Péter Horváth, Csaba Pál & Balázs Papp Published in: Nature Ecology and Evolution, 2022, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41559-022-01730-1 Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability Author(s): Alexandra Bocsik, Ilona Gróf, Lóránd Kiss, Ferenc Ötvös, Ottó Zsíros, Lejla Daruka, Lívia Fülöp, Monika Vastag, Ágnes Kittel, Norbert Imre, Tamás Martinek, Csaba Pál, Piroska Szabó-Révész, Mária A. Deli Published in: Pharmaceutics, Issue 11/2, 2019, Page(s) 73, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics11020073 Rational design of balanced dual-targeting antibiotics with limited resistance Author(s): Akos Nyerges, Tihomir Tomašič, Martina Durcik, Tamas Revesz, Petra Szili, Gabor Draskovits, Ferenc Bogar, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lejla Daruka, Balint Kintses, Balint Vasarhelyi, Imre Foldesi, Diána Kata, Martin Welin, Raymond Kimbung, Dorota Focht, Lucija Peterlin Mašič, Csaba Pal Published in: PLOS Biology, Issue 18/10, 2020, Page(s) e3000819, ISSN 1545-7885 Publisher: Public Library of Science DOI: 10.1371/journal.pbio.3000819 Proteome-wide landscape of solubility limits in a bacterial cell Author(s): Ádám Györkei, Lejla Daruka, Dávid Balogh, Erika Őszi, Zoltán Magyar, Balázs Szappanos, Gergely Fekete, Mónika Fuxreiter, Péter Horváth, Csaba Pál, Bálint Kintses & Balázs Papp Published in: Scientific Reports, 2022, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41598-022-10427-1 Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity Author(s): Máté Manczinger, Balázs Koncz, Gergő Mihály Balogh, Benjamin Tamás Papp, Leó Asztalos, Lajos Kemény, Balázs Papp & Csaba Pál Published in: Nature cancer, 2021, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s43018-021-00226-4 Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota Author(s): Bálint Kintses, Orsolya Méhi, Eszter Ari, Mónika Számel, Ádám Györkei, Pramod K. Jangir, István Nagy, Ferenc Pál, Gergely Fekete, Roland Tengölics, Ákos Nyerges, István Likó, Anita Bálint, Tamás Molnár, Balázs Bálint, Bálint Márk Vásárhelyi, Misshelle Bustamante, Balázs Papp, Csaba Pál Published in: Nature Microbiology, Issue 4/3, 2019, Page(s) 447-458, ISSN 2058-5276 Publisher: Nature Publishing Group DOI: 10.1038/s41564-018-0313-5 Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance Author(s): Réka Spohn, Lejla Daruka, Viktória Lázár, Ana Martins, Fanni Vidovics, Gábor Grézal, Orsolya Méhi, Bálint Kintses, Mónika Számel, Pramod K. Jangir, Bálint Csörgő, Ádám Györkei, Zoltán Bódi, Anikó Faragó, László Bodai, Imre Földesi, Diána Kata, Gergely Maróti, Bernadett Pap, Roland Wirth, Balázs Papp, Csaba Pál Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-12364-6 Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations Author(s): Gábor Apjok, Gábor Boross, Ákos Nyerges, Gergely Fekete, Viktória Lázár, Balázs Papp, Csaba Pál, Bálint Csörgő Published in: Molecular Biology and Evolution, Issue 36/8, 2019, Page(s) 1601-1611, ISSN 0737-4038 Publisher: Oxford University Press DOI: 10.1093/molbev/msz109 Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations Author(s): Károly Kovács; Zoltán Farkas; Djordje Bajić; Dorottya Kalapis; Andreea Daraba; Karola Almási; Bálint Kintses; Bálint Kintses; Zoltán Bódi; Richard A. Notebaart; Juan F. Poyatos; Patrick Kemmeren; Frank C. P. Holstege; Csaba Pál; Balázs Papp Published in: Molecular Biology and Evolution, 38(3), 1137 - 1150, Issue 2, 2020, ISSN 0024-2160 Publisher: Oxford University Press DOI: 10.1093/molbev/msaa280 Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations Author(s): Máté Manczinger, Gábor Boross, Lajos Kemény, Viktor Müller, Tobias L. Lenz, Balázs Papp, Csaba Pál Published in: PLOS Biology, Issue 17/1, 2019, Page(s) e3000131, ISSN 1545-7885 Publisher: Plos Biology DOI: 10.1371/journal.pbio.3000131 New dual ATP-competitive inhibitors of bacterial DNA gyrase andtopoisomerase IV active against ESKAPE pathogens Author(s): Martina Durcik,Ákos Nyerges, Žiga Skok, Darja Gramec Skledar, Jurij Trontelj, Nace Zidar, Janez Ilaš, Anamarija Zega, Cristina D.Cruz, Päivi Tammela, Martin Welin, Yengo R. Kimbung, Dorota Focht, Ondřej Benek, Tamás Révész, Gábor Draskovits, Petra Éva Szili, Lejla Daruka, Csaba Pál, Danijel Kikelj, Lucija Peterlin Mašič, Tihomir Tomašič Published in: Elsevier European Journal of Medicinal Chemistry Volume 213, 5 March 2021, 113200, 2021, ISSN 0223-5234 Publisher: Elsevier BV DOI: 10.1016/j.ejmech.2021.113200 Phenotypic heterogeneity promotes adaptive evolution Author(s): Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L. Oliveira, Gabriela Moura, Manuel A. S. Santos, Tamás Székely Jr, Gábor Balázsi, Csaba Pál Published in: PLOS Biology, Issue 15/5, 2017, Page(s) e2000644, ISSN 1545-7885 Publisher: Public Library of Science DOI: 10.1371/journal.pbio.2000644 A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species Author(s): Ákos Nyerges, Bálint Csörgő, István Nagy, Balázs Bálint, Péter Bihari, Viktória Lázár, Gábor Apjok, Kinga Umenhoffer, Balázs Bogos, György Pósfai, Csaba Pál Published in: Proceedings of the National Academy of Sciences, Issue 113/9, 2016, Page(s) 2502-2507, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1520040113 Collateral sensitivity of antibiotic-resistant microbes Author(s): Csaba Pál, Balázs Papp, Viktória Lázár Published in: Trends in Microbiology, Issue 23/7, 2015, Page(s) 401-407, ISSN 0966-842X Publisher: Elsevier BV DOI: 10.1016/j.tim.2015.02.009 Evolution of complex adaptations in molecular systems Author(s): Csaba Pál, Balázs Papp Published in: Nature Ecology & Evolution, Issue 1/8, 2017, Page(s) 1084-1092, ISSN 2397-334X Publisher: Springer Natur DOI: 10.1038/s41559-017-0228-1 Adaptive evolution of complex innovations through stepwise metabolic niche expansion Author(s): Balázs Szappanos, Jonathan Fritzemeier, Bálint Csörgő, Viktória Lázár, Xiaowen Lu, Gergely Fekete, Balázs Bálint, Róbert Herczeg, István Nagy, Richard A. Notebaart, Martin J. Lercher, Csaba Pál, Balázs Papp Published in: Nature Communications, Issue 7, 2016, Page(s) 11607, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/ncomms11607 Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining Author(s): Ildikó Karcagi, Gábor Draskovits, Kinga Umenhoffer, Gergely Fekete, Károly Kovács, Orsolya Méhi, Gabriella Balikó, Balázs Szappanos, Zsuzsanna Györfy, Tamás Fehér, Balázs Bogos, Frederick R. Blattner, Csaba Pál, György Pósfai, Balázs Papp Published in: Molecular Biology and Evolution, Issue 33/5, 2016, Page(s) 1257-1269, ISSN 0737-4038 Publisher: Oxford University Press DOI: 10.1093/molbev/msw009 Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover Author(s): Dorottya Kalapis, Ana R. Bezerra, Zoltán Farkas, Peter Horvath, Zoltán Bódi, Andreea Daraba, Béla Szamecz, Ivo Gut, Mónica Bayes, Manuel A. S. Santos, Csaba Pál Published in: PLOS Biology, Issue 13/11, 2015, Page(s) e1002291, ISSN 1545-7885 Publisher: Public Library of Science DOI: 10.1371/journal.pbio.1002291 Efflux Pump Control Alters Synthetic Gene Circuit Function Author(s): Junchen Diao, Daniel A. Charlebois, Dmitry Nevozhay, Zoltán Bódi, Csaba Pál, Gábor Balázsi Published in: ACS Synthetic Biology, Issue 5/7, 2016, Page(s) 619-631, ISSN 2161-5063 Publisher: American Chemical Society DOI: 10.1021/acssynbio.5b00154 Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides Author(s): Viktória Lázár, Ana Martins, Réka Spohn, Lejla Daruka, Gábor Grézal, Gergely Fekete, Mónika Számel, Pramod K Jangir, Bálint Kintses, Bálint Csörgő, Ákos Nyerges, Ádám Györkei, András Kincses, András Dér, Fruzsina R Walter, Mária A Deli, Edit Urbán, Zsófia Hegedűs, Gábor Olajos, Orsolya Méhi, Balázs Bálint, István Nagy, Tamás A Martinek, Balázs Papp, Csaba Pál Published in: Nature Microbiology, Issue 3/6, 2018, Page(s) 718-731, ISSN 2058-5276 Publisher: Nature Research Journals DOI: 10.1038/s41564-018-0164-0 Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity Author(s): Benedetta Fois, Žiga Skok, Tihomir Tomašič, Janez Ilaš, Nace Zidar, Anamarija Zega, Lucija Peterlin Mašič, Petra Szili, Gábor Draskovits, Ákos Nyerges, Csaba Pál, Danijel Kikelj Published in: ChemMedChem, Issue 15/3, 2020, Page(s) 265-269, ISSN 1860-7179 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.201900607 Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance Author(s): Ákos Nyerges, Bálint Csörgő, Gábor Draskovits, Bálint Kintses, Petra Szili, Györgyi Ferenc, Tamás Révész, Eszter Ari, István Nagy, Balázs Bálint, Bálint Márk Vásárhelyi, Péter Bihari, Mónika Számel, Dávid Balogh, Henrietta Papp, Dorottya Kalapis, Balázs Papp, Csaba Pál Published in: Proceedings of the National Academy of Sciences, Issue 115/25, 2018, Page(s) E5726-E5735, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1801646115 Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations Author(s): Petra Szili, Gábor Draskovits, Tamás Révész, Ferenc Bogár, Dávid Balogh, Tamás Martinek, Lejla Daruka, Réka Spohn, Bálint Márk Vásárhelyi, Márton Czikkely, Bálint Kintses, Gábor Grézal, Györgyi Ferenc, Csaba Pál, Ákos Nyerges Published in: Antimicrobial Agents and Chemotherapy, Issue 63/9, 2019, ISSN 0066-4804 Publisher: American Society for Microbiology DOI: 10.1128/aac.00207-19 Hsp70-associated chaperones have a critical role in buffering protein production costs Author(s): Zoltán Farkas, Dorottya Kalapis, Zoltán Bódi, Béla Szamecz, Andreea Daraba, Karola Almási, Károly Kovács, Gábor Boross, Ferenc Pál, Péter Horváth, Tamás Balassa, Csaba Molnár, Aladár Pettkó-Szandtner, Éva Klement, Edit Rutkai, Attila Szvetnik, Balázs Papp, Csaba Pál Published in: eLife, Issue 7, 2018, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.29845 Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion Author(s): Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, László Bodai, Balázs Papp, Csaba Pál Published in: eLife, Issue 8, 2019, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.47088 An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors Author(s): Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Tihomir Tomašič, Lucija Peterlin Mašič, Janez Ilaš, Anamarija Zega, Gábor Draskovits, Tamás Révész, Ákos Nyerges, Csaba Pál, Cristina D. Cruz, Päivi Tammela, Dušan Žigon, Danijel Kikelj, Nace Zidar Published in: European Journal of Medicinal Chemistry, Issue 167, 2019, Page(s) 269-290, ISSN 0223-5234 Publisher: Elsevier BV DOI: 10.1016/j.ejmech.2019.02.004 Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action Author(s): Bálint Kintses, Pramod K. Jangir, Gergely Fekete, Mónika Számel, Orsolya Méhi, Réka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Bálint Csörgő, Ádám Györkei, Eszter Ari, Viktória Lázár, István Nagy, Mohan Babu, Csaba Pál, Balázs Papp Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-13618-z Mismatch repair hierarchy of Pseudomonas putida revealed by mutagenic ssDNA recombineering of the pyrF gene Author(s): Tomas Aparicio, Akos Nyerges, István Nagy, Csaba Pal, Esteban Martínez‐García, Víctor Lorenzo Published in: Environmental Microbiology, Issue 22/1, 2019, Page(s) 45-58, ISSN 1462-2912 Publisher: Blackwell Publishing Inc. DOI: 10.1111/1462-2920.14814 Chemical-genetic profiling to investigate cross-resistance and collateral sensitivity between antimicrobial peptides Author(s): Kintses, Bálint; Jangir, Pramod K.; Fekete, Gergely; Számel, Mónika; Méhi, Orsolya; Spohn, Réka; Daruka, Lejla; Martins, Ana; Hosseinnia, Ali; Gagarinova, Alla; Kim, Sunyoung; Phanse, Sadhna; Csörgő, Bálint; Györkei, Ádám; Ari, Eszter; Lázár, Viktória; Faragó, Anikó; Bodai, László; Nagy, István; Babu, Mohan; Pál, Csaba; Papp, Balázs Published in: Nature Communications, Issue 3, 2019, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1101/542548 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
