Structure and mechanism of viral and cellular membrane fusion machineries

Project Information

MEMBRANEFUSION

Grant agreement ID: 648432

DOI

10.3030/648432

Project closed

EC signature date 1 April 2015

Start date 1 September 2015

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 965 961,00

EU contribution

€ 1 965 961,00

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

Author(s): Qin Yu, Kun Qu, Yorgo Modis
Published in: Molecular Cell, Issue 72/6, 2018, Page(s) 999-1012.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.10.012

Structure and architecture of immature and mature murine leukemia virus capsids

Author(s): Qu, Kun; Glass, Bärbel; Doležal, Michal; Schur, Florian K. M.; Murciano, Brice; Rein, Alan; Rumlová, Michaela; Ruml, Tomáš; Kräusslich, Hans-Georg; Briggs, John A. G.
Published in: Proceedings of the National Academy of Sciences of the United States of America, Issue 2, 2018, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1811580115

Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals

Author(s): Allen Zheng, Weina Sun, Xiaoli Xiong, Alec W. Freyn, Julia Peukes, Shirin Strohmeier, Raffael Nachbagauer, John A. G. Briggs, Florian Krammer, Peter Palese
Published in: Journal of Virology, Issue 94/16, 2020, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.00742-20

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

Author(s): William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59225

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly

Author(s): Natalya Leneva, Oleksiy Kovtun, Dustin R. Morado, John A. G. Briggs, David J. Owen
Published in: Science Advances, Issue 7/13, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abf8598

New structural insights into the multifunctional influenza A matrix protein 1

Author(s): Julia Peukes, Xiaoli Xiong, John Briggs
Published in: FEBS Letters, 2021, ISSN 1873-3468
Publisher: FEBS Press with Wiley
DOI: 10.1002/1873-3468.14194

Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant

Author(s): Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M. Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C. James, Katarzyna A. Ciazynska, Xiaoli Xiong, John A.G. Briggs, James A. Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A. Lyons, John Bradley, Steven Baker, Je
Published in: Cell Reports Medicine, Issue 1/6, 2020, Page(s) 100099, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2020.100099

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Author(s): Zunlong Ke, Joaquin Oton, Kun Qu, Mirko Cortese, Vojtech Zila, Lesley McKeane, Takanori Nakane, Jasenko Zivanov, Christopher J. Neufeldt, Berati Cerikan, John M. Lu, Julia Peukes, Xiaoli Xiong, Hans-Georg Kräusslich, Sjors H. W. Scheres, Ralf Bartenschlager, John A. G. Briggs
Published in: Nature, Issue 588/7838, 2020, Page(s) 498-502, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2665-2

Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25

Author(s): Jörg Malsam, Simon Bärfuss, Thorsten Trimbuch, Fereshteh Zarebidaki, Andreas F.-P. Sonnen, Klemens Wild, Andrea Scheutzow, Lukas Rohland, Matthias P. Mayer, Irmgard Sinning, John A.G. Briggs, Christian Rosenmund, Thomas H. Söllner
Published in: Cell Reports, Issue 32/3, 2020, Page(s) 107926, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107926

A stable immature lattice packages IP 6 for HIV capsid maturation

Author(s): Donna L. Mallery, Alex B. Kleinpeter, Nadine Renner, K. M. Rifat Faysal, Mariia Novikova, Leo Kiss, Miranda S. C. Wilson, Bilal Ahsan, Zunlong Ke, John A. G. Briggs, Adolfo Saiardi, Till Böcking, Eric O. Freed, Leo C. James
Published in: Science Advances, Issue 7/11, 2021, Page(s) eabe4716, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abe4716

Arrangements of proteins at reconstituted synaptic vesicle fusion sites depend on membrane separation

Author(s): Lucy Ginger, Joerg Malsam, Andreas F.‐P. Sonnen, Dustin Morado, Andrea Scheutzow, Thomas H. Söllner, John A. G. Briggs
Published in: FEBS Letters, Issue 594/21, 2020, Page(s) 3450-3463, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13916

Maturation of the matrix and viral membrane of HIV-1

Author(s): Kun Qu, Zunlong Ke, Vojtech Zila, Maria Anders-Össwein, Bärbel Glass, Frauke Mücksch, Rainer Müller, Carsten Schultz, Barbara Müller, Hans-Georg Kräusslich, John A. G. Briggs
Published in: Science, Issue 373/6555, 2021, Page(s) 700-704, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abe6821

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses

Author(s): George W. Carnell, Katarzyna A. Ciazynska, David A. Wells, Xiaoli Xiong, Ernest T. Aguinam, Stephen H. McLaughlin, Donna Mallery, Soraya Ebrahimi, Lourdes Ceron-Gutierrez, Benedikt Asbach, Sebastian Einhauser, Ralf Wagner, Leo C. James, Rainer Doffinger, Jonathan L. Heeney, John A. G. Briggs
Published in: Journal of Virology, Issue 95/15, 2021, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.00203-21

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Author(s): Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21695-2

Efficient 3D-CTF correction for cryo-electron tomography using NovaCTF improves subtomogram averaging resolution to 3.4 Å

Author(s): Beata Turoňová, Florian K.M. Schur, William Wan, John A.G. Briggs
Published in: Journal of Structural Biology, Issue 199/3, 2017, Page(s) 187-195, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2017.07.007

Structure and assembly of the Ebola virus nucleocapsid

Author(s): William Wan, Larissa Kolesnikova, Mairi Clarke, Alexander Koehler, Takeshi Noda, Stephan Becker & John A. G. Briggs
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group

Fluorescence-Based Detection of Membrane Fusion State on a Cryo-EM Grid using Correlated Cryo-Fluorescence and Cryo-Electron Microscopy

Author(s): Lauren Ann Metskas, John A. G. Briggs
Published in: Microscopy and Microanalysis, 2019, Page(s) 1-8, ISSN 1431-9276
Publisher: Cambridge University Press
DOI: 10.1017/s1431927619000606

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly

Author(s): Robert A. Dick, Chaoyi Xu, Dustin R. Morado, Vladyslav Kravchuk, Clifton L. Ricana, Terri D. Lyddon, Arianna M. Broad, J. Ryan Feathers, Marc C. Johnson, Volker M. Vogt, Juan R. Perilla, John A. G. Briggs, Florian K. M. Schur
Published in: PLOS Pathogens, Issue 16/1, 2020, Page(s) e1008277, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1008277

The native structure of the assembled matrix protein 1 of influenza A virus

Author(s): Julia Peukes, Xiaoli Xiong, Simon Erlendsson, Kun Qu, William Wan, Leslie J. Calder, Oliver Schraidt, Susann Kummer, Stefan M. V. Freund, Hans-Georg Kräusslich, John A. G. Briggs
Published in: Nature, Issue 587/7834, 2020, Page(s) 495-498, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2696-8

A thermostable, closed SARS-CoV-2 spike protein trimer

Author(s): Xiaoli Xiong, Kun Qu, Katarzyna A. Ciazynska, Myra Hosmillo, Andrew P. Carter, Soraya Ebrahimi, Zunlong Ke, Sjors H. W. Scheres, Laura Bergamaschi, Guinevere L. Grice, Ying Zhang, James A. Nathan, Stephen Baker, Leo C. James, Helen E. Baxendale, Ian Goodfellow, Rainer Doffinger, John A. G. Briggs
Published in: Nature Structural & Molecular Biology, Issue 27/10, 2020, Page(s) 934-941, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0478-5