Publications Peer reviewed articles (44) A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas Author(s): Shigekazu Murakami, Ivan Nemazanyy, Shannon M. White, Hengye Chen, Chan D.K. Nguyen, Garrett T. Graham, Dieter Saur, Mario Pende, Chunling Yi Published in: Developmental Cell, Issue 51/1, 2019, Page(s) 113-128.e9, ISSN 1534-5807 Publisher: Cell Press DOI: 10.1016/j.devcel.2019.07.022 A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer Author(s): Felix Dietlein, Bastian Kalb, Mladen Jokic, Elisa M. Noll, Alexander Strong, Lars Tharun, Luka Ozretić, Helen Künstlinger, Kato Kambartel, Winfried J. Randerath, Christian Jüngst, Anna Schmitt, Alessandro Torgovnick, André Richters, Daniel Rauh, Florian Siedek, Thorsten Persigehl, Cornelia Mauch, Jirina Bartkova, Allan Bradley, Martin R. Sprick, Andreas Trumpp, Roland Rad, Dieter Saur, Jiri Published in: Cell, Issue 162/1, 2015, Page(s) 146-159, ISSN 0092-8674 Publisher: Cell Press DOI: 10.1016/j.cell.2015.05.053 HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer Author(s): N Stojanovic, Z Hassan, M Wirth, P Wenzel, M Beyer, C Schäfer, P Brand, A Kroemer, R H Stauber, R M Schmid, A Arlt, A Sellmer, S Mahboobi, R Rad, M Reichert, D Saur, O H Krämer, G Schneider Published in: Oncogene, Issue 36/13, 2017, Page(s) 1804-1815, ISSN 0950-9232 Publisher: Nature Publishing Group DOI: 10.1038/onc.2016.344 In vivo functional screening for systems-level integrative cancer genomics Author(s): Julia Weber, Christian J. Braun, Dieter Saur, Roland Rad Published in: Nature Reviews Cancer, Issue 20/10, 2020, Page(s) 573-593, ISSN 1474-175X Publisher: Nature Publishing Group DOI: 10.1038/s41568-020-0275-9 Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer Author(s): Maximilian Reichert, Basil Bakir, Leticia Moreira, Jason R. Pitarresi, Karin Feldmann, Lauren Simon, Kensuke Suzuki, Ravikanth Maddipati, Andrew D. Rhim, Anna M. Schlitter, Mark Kriegsmann, Wilko Weichert, Matthias Wirth, Kathleen Schuck, Günter Schneider, Dieter Saur, Albert B. Reynolds, Andres J. Klein-Szanto, Burcin Pehlivanoglu, Bahar Memis, N. Volkan Adsay, Anil K. Rustgi Published in: Developmental Cell, Issue 45/6, 2018, Page(s) 696-711.e8, ISSN 1534-5807 Publisher: Cell Press DOI: 10.1016/j.devcel.2018.05.025 The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma Author(s): Lennart Lenk, Maren Pein, Olga Will, Beatriz Gomez, Fabrice Viol, Charlotte Hauser, Jan-Hendrik Egberts, Jan-Paul Gundlach, Ole Helm, Sanjay Tiwari, Ralf Weiskirchen, Stefan Rose-John, Christoph Röcken, Wolfgang Mikulits, Patrick Wenzel, Günter Schneider, Dieter Saur, Heiner Schäfer, Susanne Sebens Published in: OncoImmunology, Issue 7/1, 2017, Page(s) e1368603, ISSN 2162-402X Publisher: Oncoimmunology DOI: 10.1080/2162402x.2017.1368603 SUMO pathway inhibition targets an aggressive pancreatic cancer subtype Author(s): Alexander Biederstädt, Zonera Hassan, Christian Schneeweis, Markus Schick, Lara Schneider, Alexander Muckenhuber, Yingfen Hong, Gerrit Siegers, Lisa Nilsson, Matthias Wirth, Zahra Dantes, Katja Steiger, Kathrin Schunck, Steve Langston, H-P Lenhof, Andrea Coluccio, Felix Orben, Jolanta Slawska, Anna Scherger, Dieter Saur, Stefan Müller, Roland Rad, Wilko Weichert, Jonas Nilsson, Maximilian Reiche Published in: Gut, Issue 69/8, 2020, Page(s) 1472-1482, ISSN 0017-5749 Publisher: BMJ Publishing Group DOI: 10.1136/gutjnl-2018-317856 Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice Author(s): Mathias J Friedrich, Lena Rad, Iraad F Bronner, Alexander Strong, Wei Wang, Julia Weber, Matthew Mayho, Hannes Ponstingl, Thomas Engleitner, Carolyn Grove, Anja Pfaus, Dieter Saur, Juan Cadiñanos, Michael A Quail, George S Vassiliou, Pentao Liu, Allan Bradley, Roland Rad Published in: Nature Protocols, Issue 12/2, 2017, Page(s) 289-309, ISSN 1754-2189 Publisher: Nature Publishing Group DOI: 10.1038/nprot.2016.164 Analysis pipelines for cancer genome sequencing in mice Author(s): Sebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou, Mathias J. Friedrich, Dieter Saur, Ignacio Varela, Roland Rad Published in: Nature Protocols, Issue 15/2, 2020, Page(s) 266-315, ISSN 1754-2189 Publisher: Nature Publishing Group DOI: 10.1038/s41596-019-0234-7 Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology Author(s): Zahra Dantes, Hsi-Yu Yen, Nicole Pfarr, Christof Winter, Katja Steiger, Alexander Muckenhuber, Alexander Hennig, Sebastian Lange, Thomas Engleitner, Rupert Öllinger, Roman Maresch, Felix Orben, Irina Heid, Georgios Kaissis, Kuangyu Shi, Geoffrey Topping, Fabian Stögbauer, Matthias Wirth, Katja Peschke, Aristeidis Papargyriou, Massoud Rezaee-Oghazi, Karin Feldmann, Arlett P.G. Schäfer, Raphela R Published in: JCI Insight, Issue 5/15, 2020, ISSN 2379-3708 Publisher: JCI DOI: 10.1172/jci.insight.137809 Single cell polarity in liquid phase facilitates tumour metastasis Author(s): Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-018-03139-6 Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells Author(s): Lele Wang, Linlin Zhao, Guo Wei, Dieter Saur, Barbara Seidler, Junyan Wang, Chuanxin Wang, Tonggang Qi Published in: Journal of Cellular Biochemistry, Issue 119/8, 2018, Page(s) 6644-6656, ISSN 0730-2312 Publisher: John Wiley & Sons Inc. DOI: 10.1002/jcb.26847 Community-driven development of a modified progression-free survival ratio for precision oncology Author(s): Andreas Mock, Christoph E Heilig, Simon Kreutzfeldt, Daniel Huebschmann, Christoph Heining, Evelin Schröck, Benedikt Brors, Albrecht Stenzinger, Dirk Jäger, Richard Schlenk, Hanno Glimm, Stefan Fröhling, Peter Horak Published in: ESMO Open, Issue 4/6, 2019, Page(s) e000583, ISSN 2059-7029 Publisher: Esmo DOI: 10.1136/esmoopen-2019-000583 Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase Author(s): Dietrich A. Ruess, Guus J. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger, Derya Kabacaoglu, Kivanc Görgülü, Zahra Dantes, Sonja M. Wörmann, Kalliope N. Diakopoulos, Angeliki F. Karpathaki, Marlena Kowalska, Ezgi Kaya-Aksoy, Liang Song, Eveline A. Zeeuw van der Laan, María P. López-Alberca, Marc Nazaré, Maximilian Reichert, Dieter Saur, Mert M. Erkan, Ulrich T. Hopt, Bruno Sai Published in: Nature Medicine, Issue 24/7, 2018, Page(s) 954-960, ISSN 1078-8956 Publisher: Nature Publishing Group DOI: 10.1038/s41591-018-0024-8 Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation Author(s): Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-16496-y CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice Author(s): Julia Weber, Rupert Öllinger, Mathias Friedrich, Ursula Ehmer, Maxim Barenboim, Katja Steiger, Irina Heid, Sebastian Mueller, Roman Maresch, Thomas Engleitner, Nina Gross, Ulf Geumann, Beiyuan Fu, Angela Segler, Detian Yuan, Sebastian Lange, Alexander Strong, Jorge de la Rosa, Irene Esposito, Pentao Liu, Juan Cadiñanos, George S. Vassiliou, Roland M. Schmid, Günter Schneider, Kristian Unger, Fe Published in: Proceedings of the National Academy of Sciences, Issue 112/45, 2015, Page(s) 13982-13987, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1512392112 RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait Author(s): Stephanie C. Koch, Marta Garcia Del Barrio, Antoine Dalet, Graziana Gatto, Thomas Günther, Jingming Zhang, Barbara Seidler, Dieter Saur, Roland Schüle, Martyn Goulding Published in: Neuron, Issue 96/6, 2017, Page(s) 1419-1431.e5, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2017.11.011 Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells Author(s): Alexander Fabian, Simon Stegner, Lauritz Miarka, Johannes Zimmermann, Lennart Lenk, Sascha Rahn, Jann Buttlar, Fabrice Viol, Hendrike Knaack, Daniela Esser, Sascha Schäuble, Peter Großmann, Georgios Marinos, Robert Häsler, Wolfgang Mikulits, Dieter Saur, Christoph Kaleta, Heiner Schäfer, Susanne Sebens Published in: Cancer Letters, Issue 453, 2019, Page(s) 95-106, ISSN 0304-3835 Publisher: Elsevier BV DOI: 10.1016/j.canlet.2019.03.039 Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer. 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DOI: 10.1158/2159-8290.cd-19-1261 In Vivo RNAi Screening for Pancreatic Cancer Drivers: PILOTing the WDR5–MYC Axis Author(s): Günter Schneider, Dieter Saur Published in: Trends in Cancer, Issue 2/8, 2016, Page(s) 391-392, ISSN 2405-8033 Publisher: Cell Press DOI: 10.1016/j.trecan.2016.07.002 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
