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Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients

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Publications

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Author(s): Aroa Duro-Castano, Ana Sousa-Herves, Ana Armiñán, David Charbonnier, Juan José Arroyo-Crespo, Stefanie Wedepohl, Marcelo Calderón, María J. Vicent
Published in: Journal of Controlled Release, 2021, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.02.005

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Author(s): Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, Bruno G. De Geest
Published in: ACS Applied Materials & Interfaces, 13/5, 2021, Page(s) 6011-6022, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c20607

Targeting Alzheimer’s disease with Multimodal Polypeptide-based Nanoconjugates

Author(s): A. Duro-Castano, C. Borras, V. Herranz-Pérez, M.C. Blanco-Gandía, I. Conejos-Sánchez, A. Armiñan, C. Mas-Bargues, M. Inglés, J. Miñarro, M. Rodríguez-Arias, J. M. García-Verdugo, J. Viña, M.J. Vicent
Published in: Science Advances, 7, 2021, Page(s) eabf9180, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abf9180

Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

Author(s): Liane I. F. Moura, Alessio Malfanti, Carina Peres, Ana I. Matos, Elise Guegain, Vanessa Sainz, Mire Zloh, María J. Vicent, Helena F. Florindo
Published in: Materials Horizons, 6/10, 2019, Page(s) 1956-1973, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9mh00628a

Modulating angiogenesis with integrin-targeted nanomedicines

Author(s): Aroa Duro-Castano, Elena Gallon, Caitlin Decker, María J. Vicent
Published in: Advanced Drug Delivery Reviews, 119, 2017, Page(s) 101-119, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2017.05.008

Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models

Author(s): Ana Armiñán, Martina Palomino-Schätzlein, Coralie Deladriere, Juan J. Arroyo-Crespo, Sonia Vicente-Ruiz, María Jesús Vicent, Antonio Pineda-Lucena
Published in: Biomaterials, 2018, Page(s) 144-153, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.02.015

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Author(s): Stuart Atkinson, Zoraida Andreu, María Vicent
Published in: Journal of Personalized Medicine, 8/1, 2018, Page(s) 6, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm8010006

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Author(s): Juan J. Arroyo-Crespo, Coralie Deladriere, Vicent J. Nebot, David Charbonnier, Esther Masiá, Alison Paul, Craig James, Ana Armiñán, María J. Vicent
Published in: Advanced Functional Materials, 28/22, 2018, Page(s) 1800931, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201800931

Envisioning the future of polymer therapeutics for brain disorders

Author(s): Fernanda Rodriguez-Otormin, Aroa Duro-Castano, Inmaculada Conejos-Sánchez, María J. Vicent
Published in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2018, Page(s) e1532, ISSN 1939-5116
Publisher: Wiley
DOI: 10.1002/wnan.1532

Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges

Author(s): Oleksandr Zagorodko, Juan José Arroyo-Crespo, Vicent J. Nebot, María J. Vicent
Published in: Macromolecular Bioscience, 2016, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201600316

Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers

Author(s): Amaya Nino-Pariente, Vicent Nebot, Maria Vicent
Published in: Current Pharmaceutical Design, 22/9, 2016, Page(s) 1274-1291, ISSN 1381-6128
Publisher: Bentham Science Publishers
DOI: 10.2174/1381612822666151216152143

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Author(s): Juan J. Arroyo-Crespo, Ana Armiñán, David Charbonnier, Leandro Balzano-Nogueira, Francisco Huertas-López, Cristina Martí, Sonia Tarazona, Jerónimo Forteza, Ana Conesa, María J. Vicent
Published in: Biomaterials, 186, 2018, Page(s) 8-21, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.09.023

Characterization of triple‐negative breast cancer preclinical models provides functional evidence of metastatic progression

Author(s): Juan J. Arroyo‐Crespo, Ana Armiñán, David Charbonnier, Coralie Deladriere, Martina Palomino‐Schätzlein, Rubén Lamas‐Domingo, Jerónimo Forteza, Antonio Pineda‐Lucena, María J. Vicent
Published in: International Journal of Cancer, 2019, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32270

The generation of stabilized supramolecular nanorods from star-shaped polyglutamates

Author(s): O. Zagorodko, V. J. Nebot, M. J. Vicent
Published in: Polymer Chemistry, 11/6, 2020, Page(s) 1220-1229, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/C9PY01442J

Smart branched polymer drug conjugates as nano-sized drug delivery systems

Author(s): A. Duro-Castano, J. Movellan, M. J. Vicent
Published in: Biomater. Sci., 3/10, 2015, Page(s) 1321-1334, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c5bm00166h

Capturing “Extraordinary” Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design

Author(s): Aroa Duro-Castano, Vicent J. Nebot, Amaya Niño-Pariente, Ana Armiñán, Juan J. Arroyo-Crespo, Alison Paul, Natalia Feiner-Gracia, Lorenzo Albertazzi, María J. Vicent
Published in: Advanced Materials, 29/39, 2017, Page(s) 1702888, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201702888

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation

Author(s): Tetiana Melnyk, Snežana Đorđević, Inmaculada Conejos-Sánchez, María J. Vicent
Published in: Advanced Drug Delivery Reviews, 160, 2020, Page(s) 136-169, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.10.007

Molecular platforms for targeted drug delivery

Author(s): Katia Maso, Antonella Grigoletto, María J. Vicent, Gianfranco Pasut
Published in: International Review of Cell and Molecular Biology volume 346, 346, 2019, Page(s) 1-50, ISBN 9780128177242
Publisher: Elsevier
DOI: 10.1016/bs.ircmb.2019.03.001