Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients

Informazioni relative al progetto

MyNano

ID dell’accordo di sovvenzione: 648831

DOI

10.3030/648831

Progetto chiuso

Data della firma CE 5 Maggio 2015

Data di avvio 1 Luglio 2015

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 724 168,97

Contributo UE

€ 1 724 168,97

Coordinato da

FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Autori: Aroa Duro-Castano, Ana Sousa-Herves, Ana Armiñán, David Charbonnier, Juan José Arroyo-Crespo, Stefanie Wedepohl, Marcelo Calderón, María J. Vicent
Pubblicato in: Journal of Controlled Release, 2021, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.02.005

Higher-order interfiber interactions in the self-assembly of benzene-1,3,5-tricarboxamide-based peptides in water

Autori: O Zagorodko, T Melnyk, O Rogier, V J. Nebot, MJ. Vicent
Pubblicato in: Polymer Chemistry, Numero In revision, 2021, ISSN 1759-9962
Editore: Royal Society of Chemistry

Breast Cancer Models for Nanomedicine Development

Autori: Paz Boix-Montesinos, Paula Soriano, Ana Armiñán, Mar Orzáez, María J Vicent
Pubblicato in: Advanced Drug Delivery Reviews, Numero In revision, 2021, ISSN 0169-409X
Editore: Elsevier BV

Lipid-Polyglutamate Nanoparticle Vaccine Platform

Autori: Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, Bruno G. De Geest
Pubblicato in: ACS Applied Materials & Interfaces, Numero 13/5, 2021, Pagina/e 6011-6022, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c20607

Targeting Alzheimer’s disease with Multimodal Polypeptide-based Nanoconjugates

Autori: A. Duro-Castano, C. Borras, V. Herranz-Pérez, M.C. Blanco-Gandía, I. Conejos-Sánchez, A. Armiñan, C. Mas-Bargues, M. Inglés, J. Miñarro, M. Rodríguez-Arias, J. M. García-Verdugo, J. Viña, M.J. Vicent
Pubblicato in: Science Advances, Numero 7, 2021, Pagina/e eabf9180, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abf9180

Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

Autori: Liane I. F. Moura, Alessio Malfanti, Carina Peres, Ana I. Matos, Elise Guegain, Vanessa Sainz, Mire Zloh, María J. Vicent, Helena F. Florindo
Pubblicato in: Materials Horizons, Numero 6/10, 2019, Pagina/e 1956-1973, ISSN 2051-6347
Editore: Royal Society of Chemistry
DOI: 10.1039/c9mh00628a

Modulating angiogenesis with integrin-targeted nanomedicines

Autori: Aroa Duro-Castano, Elena Gallon, Caitlin Decker, María J. Vicent
Pubblicato in: Advanced Drug Delivery Reviews, Numero 119, 2017, Pagina/e 101-119, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2017.05.008

Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models

Autori: Ana Armiñán, Martina Palomino-Schätzlein, Coralie Deladriere, Juan J. Arroyo-Crespo, Sonia Vicente-Ruiz, María Jesús Vicent, Antonio Pineda-Lucena
Pubblicato in: Biomaterials, 2018, Pagina/e 144-153, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.02.015

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Autori: Stuart Atkinson, Zoraida Andreu, María Vicent
Pubblicato in: Journal of Personalized Medicine, Numero 8/1, 2018, Pagina/e 6, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm8010006

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

Autori: Juan J. Arroyo-Crespo, Coralie Deladriere, Vicent J. Nebot, David Charbonnier, Esther Masiá, Alison Paul, Craig James, Ana Armiñán, María J. Vicent
Pubblicato in: Advanced Functional Materials, Numero 28/22, 2018, Pagina/e 1800931, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201800931

Envisioning the future of polymer therapeutics for brain disorders

Autori: Fernanda Rodriguez-Otormin, Aroa Duro-Castano, Inmaculada Conejos-Sánchez, María J. Vicent
Pubblicato in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2018, Pagina/e e1532, ISSN 1939-5116
Editore: Wiley
DOI: 10.1002/wnan.1532

Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges

Autori: Oleksandr Zagorodko, Juan José Arroyo-Crespo, Vicent J. Nebot, María J. Vicent
Pubblicato in: Macromolecular Bioscience, 2016, ISSN 1616-5187
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.201600316

Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers

Autori: Amaya Nino-Pariente, Vicent Nebot, Maria Vicent
Pubblicato in: Current Pharmaceutical Design, Numero 22/9, 2016, Pagina/e 1274-1291, ISSN 1381-6128
Editore: Bentham Science Publishers
DOI: 10.2174/1381612822666151216152143

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

Autori: Juan J. Arroyo-Crespo, Ana Armiñán, David Charbonnier, Leandro Balzano-Nogueira, Francisco Huertas-López, Cristina Martí, Sonia Tarazona, Jerónimo Forteza, Ana Conesa, María J. Vicent
Pubblicato in: Biomaterials, Numero 186, 2018, Pagina/e 8-21, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2018.09.023

Characterization of triple‐negative breast cancer preclinical models provides functional evidence of metastatic progression

Autori: Juan J. Arroyo‐Crespo, Ana Armiñán, David Charbonnier, Coralie Deladriere, Martina Palomino‐Schätzlein, Rubén Lamas‐Domingo, Jerónimo Forteza, Antonio Pineda‐Lucena, María J. Vicent
Pubblicato in: International Journal of Cancer, 2019, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32270

The generation of stabilized supramolecular nanorods from star-shaped polyglutamates

Autori: O. Zagorodko, V. J. Nebot, M. J. Vicent
Pubblicato in: Polymer Chemistry, Numero 11/6, 2020, Pagina/e 1220-1229, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/C9PY01442J

Smart branched polymer drug conjugates as nano-sized drug delivery systems

Autori: A. Duro-Castano, J. Movellan, M. J. Vicent
Pubblicato in: Biomater. Sci., Numero 3/10, 2015, Pagina/e 1321-1334, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/c5bm00166h

Capturing “Extraordinary” Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design

Autori: Aroa Duro-Castano, Vicent J. Nebot, Amaya Niño-Pariente, Ana Armiñán, Juan J. Arroyo-Crespo, Alison Paul, Natalia Feiner-Gracia, Lorenzo Albertazzi, María J. Vicent
Pubblicato in: Advanced Materials, Numero 29/39, 2017, Pagina/e 1702888, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201702888

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation

Autori: Tetiana Melnyk, Snežana Đorđević, Inmaculada Conejos-Sánchez, María J. Vicent
Pubblicato in: Advanced Drug Delivery Reviews, Numero 160, 2020, Pagina/e 136-169, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.10.007

Book chapters (1)

Molecular platforms for targeted drug delivery

Autori: Katia Maso, Antonella Grigoletto, María J. Vicent, Gianfranco Pasut
Pubblicato in: International Review of Cell and Molecular Biology volume 346, Numero 346, 2019, Pagina/e 1-50, ISBN 9780128177242
Editore: Elsevier
DOI: 10.1016/bs.ircmb.2019.03.001