Objective
Cardiosphere-derived stem cell (CDC) therapy for myocardial infarction (MI) has been shown to elicit moderate beneficial effects. Research currently focuses on improving CDC administration, retention and efficacy. This proposal aims to develop Magnetic Resonance Imaging (MRI) and engineering tools to facilitate this research. Specifically, microinjection of fluorine-19 labeled CDCs will allow for MRI tracking and quantification in vivo. Non-invasive global and regional cardiac function measurements will assess efficacy of stem cell (SC) therapy. Parallel to these studies will be an independent design, synthesis, use and evaluation of fiber-enriched scaffold. The anticipated impact will be multifaceted, including the study of cardiac function in disease, and the potential applicability of generated results with cutting edge SC regenerative technologies in heart failure and prominent cardiomyopathies. Research efforts will be stimulated in manufacturing processes for scaffolds, cardiac functional assessment post-injection of SCs, and validation of their homing, engraftment and viability using cellular tracking methods.
Through a personalized career developments plan, the fellowship will allow training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing his scientific, managerial and leadership qualities. Overall, the short-term objective is the advancement of the researcher’s career in science and the broadening of his scientific horizons. The long-term objective is to establish the researcher as an independent investigator, advancing the field as a chair of a Biomedical Engineering Department.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering manufacturing engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine physiology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- medical and health sciences clinical medicine cardiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.