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Report time: 01.11.2015-01.02.2016 (3 months)
During this time we have discovered the novel reactivity mode for CF3CHN2. We have performed the corresponding synthetic experiments and already written the manuscript (attached). In this work we have also synthesized an analogues of the known antibiotic - Ciprofloxacin. The manuscript has been already published in one of the the most prestigious chemistry journals - Organic Letters.
(1) ""Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom.""
Arkhipov A. V.; Arkhipov V. V.; Cossy J.; Kovtunenko V. O.; Mykhailiuk P. K.
Org. Lett. 2016, 18 (14), 3406-3409.
Financial support by Marie-Curie (Horizon 2020, 654260) is acknowledged in the manuscript.
Report time: 01.02.2015-31.10.2016 (9 months)
During this time we have accomplished several projects on the novel reactivity of CF3CHN2, C2F5CHN2 and CF2HCHN2. We have performed the corresponding synthetic experiments and already written two manuscripts. One manuscript has already been published, while another one is accepted:
(2) ""Synthesis of Fluoroalkyl Pyrazoles from In-Situ-Generated C2F5CHN2 and Electron-Deficient Alkenes.""
Mykhailiuk P.; Ishchenko A.; Stepanenko V.; Cossy J.
Eur. J. Org. Chem. 2016, in press (DOI: 10.1002/ejoc.201600947).
(3) ""Synthesis of CF2H-pyrazolines by [3+2]-cycloaddition between CF2HCHN2 and electron-deficient alkenes.""
Jue Li, Xin-Ling Yu, Janine Cossy, Song-Yang Lv, Hai-Long Zhang, Fu Su, Li Hai, Pavel K. Mykhailiuk, Yong Wu
Eur. J. Org. Chem. 2016, accepted (DOI: 10.1002/ejoc.201610165).
The text of the both manuscripts is attached.
Financial support by Marie-Curie (Horizon 2020, 654260) is acknowledged in the both manuscripts.
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