Objective
Faithful transfer of genetic material is critical for the success of all cell divisions. Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes. This can lead to cancer in mitotic cells, and in the female germline it leads to reduced fertility and exponential increase in miscarriages and birth defects already at the third decade of life. In humans, all the oocytes begin their development in-utero but arrest for decades in the middle of this process leading to the rapid increase in meiotic divisions failure. The oocytes arrest while undergoing dramatic structural changes, termed chromosome remodelling. Very little is known about what drives this critical phase in germline development, yet it is assumed to involve chromatin modifiers and DNA binding complexes. I propose to identify chromatin-modifying complexes that act in chromosome remodelling and find their mechanism of operation. This will be achieved by utilizing my recently developed technologies and RNAi screen results, which gives me unique tools and approaches to study this complex process. This research will open the window into the connection between chromatin modifiers that facilitate chromosome restructuring and germline aging. The research is aimed to find the major players in this processes and their mode of operation. In an age where maternal age is rising in the western world, translational implementation of this research would have a dramatic impact on our scientific understanding of fertility.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- social sciences sociology demography fertility
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.