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Sex differences in expression in the shared genome

Objective

Males and females in many animals are strikingly different in behaviour, physiology, shape and form. In humans, rates of ageing and disease incidence vary markedly between the sexes. Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern. Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4. Despite their ubiquity and clear biomedical importance, the evolutionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome?

My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila melanogaster. The results from this project will create comprehensive understanding of sex-specific gene regulation and evolution. This broad research has important implications for medical, developmental and evolutionary studies of sex differences and addresses a key aim, as identified by the European Commission, for research excellence in Horizon 2020.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/clinical medicine/andrology
  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /natural sciences/biological sciences/biological behavioural sciences/behavioural ecology
  • /natural sciences/biological sciences/ecology
  • /medical and health sciences/basic medicine/physiology
  • /natural sciences/biological sciences/zoology/ornithology

Call for proposal

H2020-MSCA-IF-2014
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 183 454,80