Objective
Hyperglycaemia in type 2 diabetes (T2D) doubles mortality and arises due to failure of pancreatic β-cell insulin secretory function to overcome insulin resistance. Exercise reduces hyperglycaemia by improving insulin sensitivity and β-cell function; however, the variability of this beneficial effect is huge and is associated with high blood glucose and poor insulin secretion. Hyperglycaemia increases interleukin-(IL)1β levels causing β-cell death and insulin secretory dysfunction (glucotoxicity), and these phenomena are all elevated in T2D and are also augmented by IL-6, which alone is not toxic to β-cells. Interestingly, blood IL-6 levels are not only increased in T2D but are also increased following exercise due to secretion from muscle. Therefore the huge variability in the adaptation to exercise may be due to muscle IL-6-induced enhancement of IL-1β-induced β-cell dysfunction. Thus, exercise may be detrimental to T2D patients with β-cell glucotoxicity. Our objective is to determine the independent and interactive roles of IL-6 and IL-1β in the adaptations to exercise in T2D. We will achieve this by integrating the human physiology expertise of the Experienced Researcher with the transgenic mouse model expertise of the Supervisor to create a bench-to-bedside approach from which both the host institution and the experienced researcher will gain from in the future. Innovative muscle-specific IL-6 knockout mouse models and clinical anti-IL-1β drug treatment approaches will be used to ultimately increase the knowledge of how IL-6 and IL-1β interact, making it possible to optimise exercise therapy for all T2D patients, including those who would otherwise be classified as a “non-responder”.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine endocrinology diabetes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.