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First Chemoselective Synthesis and Structural Studies of Lasso Peptides

Objective

The main objective of this project is to promote the use of peptides as potential therapeutic agents. We now know that ribosomal peptides, and specifically lasso peptides, which are biosynthesized by bacteria as agents of defense, show a compact and rigid structure, giving a high stability against physical, chemical and proteolytic degradation. The spectrum of biological activities of these peptides is very wide, acting as antibiotics and also as enzymatic inhibitors, such as the case of the HIV virus protease. Thus, they show a great potential as a therapeutic alternative to existing drugs. To achieve this goal, the project is divided into two distinct parts, to be performed in the two chosen sites, strategically combining the synthetic aspects (TSRI, San Diego) with the structural determination and their involvement in recognition molecular processes (CIB-CSIC, Madrid) .
Firstly, synthetic efforts will be made to chemically synthesize the lasso microcin J25 (MccJ25). It will be an extraordinary example of how we, chemists, can use very complex chemoselective reactions, which are usually reserved for biosynthetic enzymes. During the second part of the project, the first structural studies of Lasso peptides-protein complexes will be accomplished using the synergy of combining NMR with computation methods.
The selected research centers to achieve this project are: The Scripps Research Institute (TSRI), being the project supervisor Prof. Phil Baran and Centro de Investigaciones Biológicas (CIB-CSIC), with Prof. Jesús Jiménez-Barbero. Both research groups and centers have a well-gained international prestige.

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Topic(s)

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MSCA-IF-GF - Global Fellowships

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2014

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Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 257 191,20
Address
PARQUE TECNOLOGICO EDIFICIO 801 A
48160 DERIO VIZCAYA
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 257 191,20

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