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Symbiotic bacteria in midges: understanding their role in determining vector competence and transmission of viruses

Objective

The health of livestock is commonly impacted by viruses acquired from midge vectors. The viruses transferred following a midge bite cause considerable economic losses across the EU, making control of midges/midge vector competence a pressing concern. Recent research has indicated some inherited symbionts may alter the vector competence of their insect host, and thus represent viable means of interrupting pathogen transmission in natural populations. However, reduction of vector competence has only been considered for Wolbachia symbiont infections, and for viruses of importance to human health. Midges, in contrast, are commonly infected with a Cardinium heritable symbiont with unknown properties. This project seeks to establish tools for understanding this symbiont, and investigate whether it affects host immune system activity and vector competence following exposure to an infected blood meal. This proposal will thus provide both fundamental understanding of a poorly studied symbiont in an important host group, and, more practically, evaluate whether alteration of symbiont presence is a viable means of interrupting viral transmission.

Call for proposal

H2020-MSCA-IF-2014
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Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE UNIVERSITY OF LIVERPOOL
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 183 454,80