Structural role of protein splicing factors in promoting an active configuration of the spliceosome's RNA catalytic core

Project Information

SpliceosomeStructure

Grant agreement ID: 657492

DOI

10.3030/657492

Project closed

EC signature date 24 March 2015

Start date 1 March 2016

End date 28 February 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 183 454,80

EU contribution

€ 183 454,80

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Cryo-EM structure of the spliceosome immediately after branching

Author(s): Wojciech P. Galej, Max E. Wilkinson, Sebastian M. Fica, Chris Oubridge, Andrew J. Newman, Kiyoshi Nagai
Published in: Nature, Issue 537/7619, 2016, Page(s) 197-201, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature19316

Structure of a spliceosome remodelled for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson, Xiao-Chen Bai, Andrew J. Newman, Kiyoshi Nagai
Published in: Nature, Issue 542/7641, 2017, Page(s) 377-380, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature21078

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

Author(s): Sebastian M Fica, Kiyoshi Nagai
Published in: Nature Structural & Molecular Biology, Issue 24/10, 2017, Page(s) 791-799, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3463

Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection

Author(s): Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Christine M. Norman, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, Issue 358/6368, 2017, Page(s) 1283-1288, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar3729