Objective
Over the recent years, research in developmental biology has stumbled upon the problem of how development ensures that organisms achieve appropriate body and organ size. The coordination of organ growth with the developmental program is essential for the emergence of adults with proper body size and proportions. These species-specific features condition many traits of adult life such as fitness and survival. Studies on fruit flies have allowed setting up the conceptual frame for this research. Our current understanding is that tissue growth and the developmental program are synchronized by feedback control mechanisms that block the transition to the next developmental period until all tissues have completed growth.
Recent work in Drosophila has started unraveling the nature of the signals that couple tissue growth with developmental progression. A newly discovered Drosophila insulin-like peptide called Dilp8 is key in this coupling, raising the possibility that peptides with similar roles may exist in vertebrates. The current project aims at characterizing the molecular mechanisms by which Dilp8 coordinates development of the different body parts. First, I will conduct a biased genetic screen to identify the receptor for Dilp8. This will allow a better characterization of the biological functions of Dilp8. On one hand, I will unravel the target tissues of Dilp8 mediating regulation of steroid hormone and developmental transitions. On the other hand, I will investigate the role of Dilp8 signaling in coordinating growth among developing organs.
The project will shed light on the mechanisms of inter-organ communication that ensure the coordination of growth between tissues and with the developmental timing. The expertise of the host laboratory, combined the conceptual frame and experimental approaches of the project, will allow me to gain new skills and scientific knowledge, and to develop a successful research career in the field of growth control.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences health sciences inflammatory diseases
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences developmental biology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.