Objective For some time allenes were considered simple curiosities because of their apparent unstable nature. However, in the last few years the chemistry of allenes has been extensively developed since they have shown an interesting reactivity and selectivity affording complex structures in an atom economic manner. Bis-allenes have recently appeared as useful building blocks for the synthesis of carbo- and heterocycles. However, their reaction with nucleophiles has barely been studied.The main objective of this project deals with a recently discovered Pt-catalysed reaction of bis-allenes with oxygen nucleophiles leading to seven membered cycles with a molecule of the nucleophile incorporated in the final skeleton. This new reaction could involve a double coordination of the Pt atom to both allenes, but the mechanism remains unclear. Recent studies in Dr Muñoz’s group suggest that the Pt, in addition to the more common η2-coordination with the allene, can also appear as a η1-structure, with the Pt atom coordinated to the central carbon of the allene. The discoveries in this field highlight the importance of acquiring knowledge in the bis-allene coordination, since this information could lead to the preparation of more selective catalyst as well as the isolation of reactive intermediates that can be milestones for the construction of new interesting scaffolds. The present project attempts to shed light into the Pt-bis-allene interaction, to exploit the implications of the coordination modes in the reaction mechanisms, and to apply the gained knowledge to the synthesis of new natural-product like structures with potential biological activity. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencesorganic chemistryalcoholsnatural scienceschemical sciencescatalysisnatural sciencesphysical sciencesopticsspectroscopy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITY OF EAST ANGLIA Net EU contribution € 91 727,40 Address Earlham road NR4 7TJ Norwich United Kingdom See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
