Objetivo Natural Products (NPs) are key to medicine, yet the generation of analogues of these important compounds can often be challenging. I propose to investigate an exciting new approach to NP analogues pioneered by the Goss lab. By developing new, mild, aqueous and selective cross-coupling chemistries I will enable the selective diversification of organic molecules, and in particular NPs, containing carbon-halogen bonds. With my expertise in organometallic chemistry and computational chemistry and in collaboration with the Goss lab, we are poised to bring significant advance to this new field of research.Over 5000 halogenated NPs have been isolated and identified to date, presenting a series of attractive test-beds for this proposed research. Additionally, with the advent of synthetic biology, it has recently been possible for the Goss group and others to engineer new to nature NPs containing halogen handles. The Goss group demonstrated selective functionalization of these NPs developing and using mild and aqueous Suzuki Miyaura cross-coupling conditions. Building upon this success, I will develop methodology to enable, under mild aqueous conditions, a greater diversity of cross-coupling reactions of aryl halide containing small molecules and then NPs to be employed. I will then embrace the challenge of the selective functionalization of the less reactive vinyl and alkyl halides, first in the presence of small molecules and then in the context of NPs. My reaction design, in this challenging area, will be informed by recent literature precedent, and my own DFT calculations. Success will both enable access to libraries of previously inaccessible NP analogues and provide the first steps toward being able to carry out these chemical reactions in tissues and perhaps even in live organisms in a bioorthogonal manner. Ámbito científico natural sciencesbiological sciencessynthetic biologymedical and health sciencesbasic medicinemedicinal chemistrynatural scienceschemical sciencesinorganic chemistryorganometallic chemistrynatural scienceschemical sciencesinorganic chemistryhalogens Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2014 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Aportación neta de la UEn € 183 454,80 Dirección NORTH STREET 66 COLLEGE GATE KY16 9AJ St Andrews Reino Unido Ver en el mapa Región Scotland Eastern Scotland Clackmannanshire and Fife Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 183 454,80