Complex parasite communities as drivers of bacterial immunity

Información del proyecto

PHAGECOM

Identificador del acuerdo de subvención: 660039

DOI 10.3030/660039

Proyecto cerrado

Fecha de la firma de la CE 17 Marzo 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2017

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 183 454,80

Aportación de la UE € 183 454,80

Coordinado por

THE UNIVERSITY OF EXETER
Reino Unido

Objetivo

CRISPR-Cas is one of several distinct bacterial defence mechanisms that provide immunity against viruses (phages) and other mobile genetic elements (MGEs; e.g. plasmids). My research aims at understanding how CRISPR-Cas-mediated immunity is affected by the complexity of MGE communities. Using evolution assays and deep sequencing techniques I aim to study (i) the evolution of CRISPR-Cas-mediated immunity in a complex MGE community (i.e. multiple phages and plasmids), and (ii) determine the associated co-evolutionary dynamics. The proposed research is highly multidisciplinary and will perfectly complement my background in biochemistry and molecular biology. It also allows me to establish collaborations with academic and industrial partners to realize applications in dairy industry and phage therapy. The project will be pivotal for my personal development to become an independent researcher and offers me the unique opportunity to work in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter. Biosciences is a leading institute in evolutionary biology, microbiology and ecology that provides excellent opportunities for academic training and personal career development. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my own background, offering exciting opportunities for knowledge exchange and will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures for the general public throughout 2015 (the Year of the Phage) to emphasize the importance of phage research for many aspects of our society, including industry and medicine.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• ciencias naturales › ciencias biológicas › microbiología › bacteriología
• ciencias naturales › ciencias biológicas › microbiología › virología
• ciencias naturales › ciencias biológicas › biología evolutiva
• ciencias naturales › ciencias biológicas › genética › genoma
• ciencias naturales › ciencias biológicas › biología molecular › evolución molecular

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Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Tema(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Convocatoria de propuestas

H2020-MSCA-IF-2014

Régimen de financiación

MSCA-IF-EF-ST -

Coordinador

THE UNIVERSITY OF EXETER

• Aportación neta de la UEn: € 183 454,80
• Dirección: THE QUEEN'S DRIVE NORTHCOTE HOUSE ; EX4 4QJ Exeter ; Reino Unido
• Región: South West (England) › Devon › Devon CC
• Tipo de actividad: Institutos de educación secundaria o superior
• Coste total: € 183 454,80