Periodic Reporting for period 1 - ORSETOSY (Organocatalysis at the service of total synthesis: Madangamine alkaloids)
Reporting period: 2015-04-27 to 2017-04-26
Also, new methodologies towards the formation of highly decorated fully substituted amines have been developed. A new photoredox approach allows the umpolung functionalisation of in situ formed imines through the generation of an alpha amino radical which can react with electron deficient alkenes. This methodology could be of great use in total synthesis but also in the creation of libraries of compounds.
Additionally, a new high yield and highly chemoselective Ir catalysed tertiary amide cyanation has been developed and applied to the synthesis of different compounds of interest as well as for the late stage functionalization of complex molecules. Due to the versatility of the nitrile group, which can be converted into a bunch of different functional groups, this reaction could be of great interest.