Objective
The aim of this proposal is to propose a scientific research project and a training plan for Dr. Brenda Rocamonde. The scientific research project aims to understand the function of the transcriptional regulator Id4 in the adult subventricular zone (SVZ) under physiological and pathological conditions. The SVZ is one of the largest neurogenic niches of the adult brain, generating new neurons from neural stem and progenitor cells, throughout adulthood. This region is activated after brain injury, such as ischemic stroke. Inhibitor of DNA binding 4 (Id4) is a transcriptional regulator that acts by antagonizing transcription factors. In the developing brain, Id4 is required for neural progenitor cell proliferation and differentiation. However, the function of Id4 in the adult SVZ has not been reported. We have observed that Id4 is expressed in neural stem cells and cells of the neuronal lineage in the adult SVZ. We propose to use in vivo approaches to (i) determine Id4 function in the SVZ by loss and gain of function approaches, and (ii) evaluate its role in the response of the SVZ to ischemic stroke, a major cause of disability in Europe. This project, undertaken in an international research center and carried out by a talented fellow will provide insights into the mechanisms underlying the regulation of adult neurogenesis in the normal and injured brain. In addition, we are proposing a career development plan for Dr. Rocamonde that includes training on scientific and transferable skills. This plan will widen Dr. Rocamonde’s competences and provide her with the tools to become a leading independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.