Skip to main content
Weiter zur Homepage der Europäischen Kommission (öffnet in neuem Fenster)
Deutsch de
CORDIS - Forschungsergebnisse der EU
CORDIS

Role of Id4 in the adult subventricular zone of normal and injured brain

Ziel

The aim of this proposal is to propose a scientific research project and a training plan for Dr. Brenda Rocamonde. The scientific research project aims to understand the function of the transcriptional regulator Id4 in the adult subventricular zone (SVZ) under physiological and pathological conditions. The SVZ is one of the largest neurogenic niches of the adult brain, generating new neurons from neural stem and progenitor cells, throughout adulthood. This region is activated after brain injury, such as ischemic stroke. Inhibitor of DNA binding 4 (Id4) is a transcriptional regulator that acts by antagonizing transcription factors. In the developing brain, Id4 is required for neural progenitor cell proliferation and differentiation. However, the function of Id4 in the adult SVZ has not been reported. We have observed that Id4 is expressed in neural stem cells and cells of the neuronal lineage in the adult SVZ. We propose to use in vivo approaches to (i) determine Id4 function in the SVZ by loss and gain of function approaches, and (ii) evaluate its role in the response of the SVZ to ischemic stroke, a major cause of disability in Europe. This project, undertaken in an international research center and carried out by a talented fellow will provide insights into the mechanisms underlying the regulation of adult neurogenesis in the normal and injured brain. In addition, we are proposing a career development plan for Dr. Rocamonde that includes training on scientific and transferable skills. This plan will widen Dr. Rocamonde’s competences and provide her with the tools to become a leading independent researcher.

Wissenschaftliches Gebiet (EuroSciVoc)

Programm/Programme

Thema/Themen

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Alle im Rahmen dieses Finanzierungsinstruments finanzierten Projekte anzeigen

Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) H2020-MSCA-IF-2014

Alle im Rahmen dieser Aufforderung zur Einreichung von Vorschlägen finanzierten Projekte anzeigen

Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Netto-EU-Beitrag
€ 173 076,00
Adresse
RUE DE TOLBIAC 101
75654 Paris
Frankreich
Region
Ile-de-France Ile-de-France Paris
Aktivitätstyp
Research Organisations
Links
Gesamtkosten
€ 173 076,00