Objective
Atherosclerosis is a disease of the arteries. It leads to the formation of atherosclerotic plaques (atheromas), which may disrupt the blood flow to target organs, leading to heart disease and stroke - the most common causes of death in developed countries. Cardiovascular imaging has traditionally focused on the anatomy of the atherosclerotic plaque; however, the degree of vessel narrowing caused by the plaque isn’t the only characteristic that can determine the clinical outcome. Indeed, the cellular and molecular composition of the atheroma can indicate whether the plaque might cause complications. In particular the local immune-inflammatory response participates from the onset of the pathology through its progression, up to clinical manifestations. Consequently the development of innovative approaches for the molecular imaging of inflammation in atherosclerosis would be key to improve diagnosis and treatment.
In the last decade molecular imaging has emerged as a novel tool for the visualization and measurement of biological processes in atheromas. Various imaging technologies have been developed; however, each approach presents severe weaknesses. Surface Enhancement Raman Spectroscopy (SERS) is developing as an effective molecular imaging optical modality in biomedicine because it offers many advantages over traditional technologies, including better sensitivity, and a superior multiplexing capability. Therefore, the primary aim of the present proposal is to develop innovative, highly-sensitive and selective but relatively affordable SERS-based system to measure inflammation in atherosclerotic vessels. I will use nanoparticles (NPs), small metallic particles, which possess the ability to recognise inflammatory markers, as imaging probes. When a light source is shone on these NPs, they can be detected by SERS. The secondary aim is to customise the NPs to enable local treatment of the pathology. The proposed approaches will offer new ways to manage atherosclerosis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
- engineering and technology nanotechnology nano-materials
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
G12 8QQ Glasgow
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.