Objective
Protozoan pathogens from the kinetoplastid radiation (Leishmania, Trypanosoma) cause major diseases affecting humans, livestock and plants in the developing World and are an emerging problem in the developed world. Despite their importance for human health, these pathogens are still poorly studied with respect to the plasticity of their genomes and its importance for pathogen biology. The increasing availability of complete genomes provides opportunities to gain a better understanding of their genome content, to understand the role of gene flow in providing new pathogenic abilities and to identify how pathogens differ from their free-living relatives and from their hosts. The proposal involves a promising researcher from Paris, France, with a background in biochemistry and computer science moving to a host laboratory in Newcastle, UK, noted for excellent training of young researchers, and for its research on pathogen evolution, to undertake a multidisciplinary investigation, combining phylogenetics and network-based methods to identify how vertical and lateral/horizontal gene flow have affected the genomes and metabolism of these important pathogens. Host training in analysing pathogen genome evolution and large datasets using sophisticated Bayesian methods for statistical inference will synergistically complement the skills of the researcher in network and graph approaches, to achieve these goals. The project will equip the researcher with generally applicable expertise in computational analysis of large data sets from an evolution perspective and in their biological interpretation. It will deliver the first detailed insights into how lateral gene flow has affected the genomes of strategically chosen pathogens of the kinetoplastid radiation, and it will have general implications for understanding how all eukaryotic genomes, including our own, have evolved and continue to evolve.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics applied mathematics statistics and probability bayesian statistics
- natural sciences biological sciences microbiology protozoology
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.