Objective "Despite years of promise, an odor-emitting component in devices such as televisions, phones, computers and more has yet to be developed. Two major obstacles in the way of such development are poor understanding of the olfactory code (the link between odorant structure, neural activity, and odor perception), and technical inability to emit odors in a reversible manner. Here we propose a novel multidisciplinary path to solving this basic scientific question (the code), and in doing so generate a solution to the technical limitation (controlled odor emission). The Bachelet lab will design DNA strands that assume a 3D structure that will specifically bind to a single type of olfactory receptor and induce signal transduction. These DNA-based ""artificial odorants"" will be tagged with a nanoparticle that changes their conformation in response to an external electromagnetic field. Thus, we will have in hand an artificial odorant that is remotely switchable. The Hansson lab will use tissue culture cells expressing insect olfactory receptors, functional imaging, and behavioral tests to validate the function and selectivity of these switchable odorants in insects. The Carleton lab will use imaging in order to investigate the patterns of neural activity induced by these artificial odorants in rodents. The Sobel lab will apply these artificial odorants to the human olfactory system, and measure perception and neural activity following switching the artificial smell on and off. Finally, given a potential role for olfactory receptors in skin, the Del Rio lab will test the efficacy of these artificial odorants in promoting wound healing. At the basic science level, this approach may allow solving the combinatorial code of olfaction. At the technology level, beyond novel pharmacology, we will provide proof-of-concept for countless novel applications ranging from insect pest-control to odor-controlled environments and odor-emitting devices such as televisions, phones, and computers." Fields of science natural sciencesphysical scienceselectromagnetism and electronicselectromagnetismmedical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological scienceszoologyentomologymedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Call for proposal H2020-FETOPEN-2014-2015 See other projects for this call Sub call H2020-FETOPEN-2014-2015-RIA Funding Scheme RIA - Research and Innovation action Coordinator WEIZMANN INSTITUTE OF SCIENCE Net EU contribution € 1 019 156,00 Address Herzl street 234 7610001 Rehovot Israel See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 019 156,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all BAR ILAN UNIVERSITY Participation ended Israel Net EU contribution € 0,00 Address Bar ilan university campus 52900 Ramat gan See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany Net EU contribution € 844 610,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 844 610,00 UNIVERSITE DE GENEVE Switzerland Net EU contribution € 713 524,00 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 713 524,00 UNIVERSIDAD CARLOS III DE MADRID Spain Net EU contribution € 474 436,50 Address Calle madrid 126 28903 Getafe (madrid) See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 509 560,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ Spain Net EU contribution € 18 676,00 Address Avenida de los reyes catolicos 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 18 676,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRO DE INVESTIGACIONES ENERGETICAS MEDIOAMBIENTALES Y TECNOLOGICAS Spain Net EU contribution € 16 447,50 Address Avenida complutense 40 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 16 447,50 AUGMANITY NANO LTD Israel Net EU contribution € 892 219,00 Address 8 hamada st 7670308 Rehovot See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 892 219,00