Objective
"Despite years of promise, an odor-emitting component in devices such as televisions, phones, computers and more has yet to be developed. Two major obstacles in the way of such development are poor understanding of the olfactory code (the link between odorant structure, neural activity, and odor perception), and technical inability to emit odors in a reversible manner. Here we propose a novel multidisciplinary path to solving this basic scientific question (the code), and in doing so generate a solution to the technical limitation (controlled odor emission). The Bachelet lab will design DNA strands that assume a 3D structure that will specifically bind to a single type of olfactory receptor and induce signal transduction. These DNA-based ""artificial odorants"" will be tagged with a nanoparticle that changes their conformation in response to an external electromagnetic field. Thus, we will have in hand an artificial odorant that is remotely switchable. The Hansson lab will use tissue culture cells expressing insect olfactory receptors, functional imaging, and behavioral tests to validate the function and selectivity of these switchable odorants in insects. The Carleton lab will use imaging in order to investigate the patterns of neural activity induced by these artificial odorants in rodents. The Sobel lab will apply these artificial odorants to the human olfactory system, and measure perception and neural activity following switching the artificial smell on and off. Finally, given a potential role for olfactory receptors in skin, the Del Rio lab will test the efficacy of these artificial odorants in promoting wound healing. At the basic science level, this approach may allow solving the combinatorial code of olfaction. At the technology level, beyond novel pharmacology, we will provide proof-of-concept for countless novel applications ranging from insect pest-control to odor-controlled environments and odor-emitting devices such as televisions, phones, and computers."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences electromagnetism and electronics electromagnetism
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences zoology entomology
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
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H2020-EU.1.2.1. - FET Open
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
RIA - Research and Innovation action
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2014-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7610001 Rehovot
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.