NanoSmells: Artificial remote-controlled odorants

Informations projet

NanoSmell

N° de convention de subvention: 662629

DOI

10.3030/662629

Projet clôturé

Date de signature de la CE 27 Mai 2015

Date de début 1 Septembre 2015

Date de fin 31 Août 2019

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 979 069,00

Contribution de l’UE

€ 3 979 069,00

Coordonné par

WEIZMANN INSTITUTE OF SCIENCE
Israel

Periodic Reporting for period 3 - NanoSmell (NanoSmells: Artificial remote-controlled odorants)

Période du rapport: 2018-03-01 au 2019-08-31

Résumé du contexte et des objectifs généraux du projet

Nanosmell is a project where we aim to use nanotechnology, or more specifically developments of a method known as DNA origami, in order to shape strands of DNA into ligands for specific olfactory receptors. We call these intended designer odorants NanoSmells. Moreover, we aim to design a remote switch into NanoSmells such that we will be able to turn these odors “on” and “off” remotely. In the project, the Bachelet lab (Augmanity, Israel) will use nanotechnology to design and generate NanoSmells, the Hansson lab (Max Plank, Germany) will test the response to NanoSmells in the insect brain and behavior, the Carleton lab (University of Geneva, Switzerland) will test the response to NanoSmells in the rodent brain and behavior, the Del-Rio lab (University of Madrid, Spain) will test the effectiveness of NanoSmells as agents of healing skin wounds, something natural odorants may do. Finally, the Sobel lab (Weizmann Institute, Israel), the coordinating lab, will test the response to NanoSmells in human brain and behavior. If successful, on the basic science side this high-risk high-gain project may provide definitive insight into how the brain codes odors, and on the technology side this project may pave the way for odor into media, including controlled odor-emitting phones, televisions, computers and beyond.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

In this project we set out to generate artificial remote-controlled odorants made out of DNA, and designed to target specific olfactory receptors.

Despite significant efforts, we have failed to achieve our primary aim

FET Open is touted as designated for "high-risk high-gain". If all "high-risk high-gain" projects always succeed, then they were not really high-risk. This project really was high-risk, and despite our efforts, this risk materialized. That said, our efforts were not without fruits. Some of these outcomes may be game-changing, even if not in the originally intended manner. Finally, we should note that despite the (premature) end of this funding mechanism, we are not lifting our hands from this effort, and are continuing to try and generate NanoSmells.

Of the achievements made in this project, we would like to highlight:

1. Bachelet lab: A novel method for aptamer selection, that may allow progress in areas such as drug development
2. Hansson lab: A method for expression of Drosophila olfactory receptors in mammalian cells
3. Sobel lab: A valid metric for odor perception in humans that may provide a computational backbone for digitising smell
4. Carleton lab: A neural metric for odorant similarity in mice that may significantly advance our understanding of how the brain codes smelll
5. Del Rio lab: Aptamers (NanoSmells) that promote wound-healing.

Each of these alone are significant scientific achievements. Thus, although NanoSmell may have failed to meet its technological goals, it has made significant scientific contributions. Moreover, if the Del Rio lab achievement holds, and leads to an actual product to treat skin wounds, this will reflect accomplishment of a stated goal of NanoSmell, an accomplishment that, in our view, alone justifies the entire effort.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

In addition to the above-stated five major achievements, we have also generated a novel method for human deep brain stimulation. This may provide a novel path to treatment of conditions such as intractable epilepsy and depression.

A novel method for aerosolizing NanoSmells