Objective
Under an ERC Advanced Grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in pluripotent stem cell culture as well as being applicable to many other mammalian cell types. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant funding has allowed exemplification of the delivery of proteins that promote pluripotency or differentiation, delivery and expression of mRNA and high yield delivery of nano and microparticles.
This Proof-of-Concept Application will achieve 6 deliverables that together will generate a robust business plan for commercialisation of GET. We begin by performing, via a European marketing company, a comprehensive market analysis to test our view that GET could be used to replace lentiviral transfection, or as an in vivo reprogramming tool or for other challenngng pharmaceutical applications. Next we take account of the market analysis to refine our technical work resulting in a report that provides robust evidence of market required advantages of GET over competitor products. This technical work will include a consideration of manufacturing routes and costs of goods. In parallel with the technical work we will commission an independent freedom-to-operate report. Finally, we will initiate confidential discussions with potential partners and customers via face-to-face meetings in Europe and the US.
The final business plan will establish the technical and commercial feasibility of our approaches in one or more of our target markets. We envisage that at the end of the ERC PoC grant we will attract substantial funding to rapidly progress product launches and licenses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2014-PoC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NG7 2RD Nottingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.