The molecular basis of CULLIN E3 ligase regulation by the COP9 signalosome

Project Information

CsnCRL

Grant agreement ID: 666068

DOI 10.3030/666068

Project closed

EC signature date 26 August 2015

Start date 1 January 2016

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 200 677,00

EU contribution € 2 200 677,00

Coordinated by

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

Publications

Peer reviewed articles (10)

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Author(s): Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard D. Bunker, Katherine A. Donovan, Quinlan L. Sievers, Jonas Koeppel, Dakota Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä, Benjamin L. E
Published in: Nature, Issue 585/7824, 2020, Page(s) 293-297, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2374-x

DNA damage detection in nucleosomes involves DNA register shifting

Author(s): Syota Matsumoto, Simone Cavadini, Richard D. Bunker, Ralph S. Grand, Alessandro Potenza, Julius Rabl, Junpei Yamamoto, Andreas D. Schenk, Dirk Schübeler, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka, Nicolas H. Thomä
Published in: Nature, Issue 571/7763, 2019, Page(s) 79-84, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1259-3

Structural mechanism of cGAS inhibition by the nucleosome

Author(s): Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
Published in: Nature, Issue 587/7835, 2020, Page(s) 668-672, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

Mechanisms of OCT4-SOX2 motif readout on nucleosomes

Author(s): Alicia K. Michael, Ralph S. Grand, Luke Isbel, Simone Cavadini, Zuzanna Kozicka, Georg Kempf, Richard D. Bunker, Andreas D. Schenk, Alexandra Graff-Meyer, Ganesh R. Pathare, Joscha Weiss, Syota Matsumoto, Lukas Burger, Dirk Schübeler, Nicolas H. Thomä
Published in: Science, Issue 368/6498, 2020, Page(s) 1460-1465, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb0074

Structural insights into Fe–S protein biogenesis by the CIA targeting complex

Author(s): Susanne A. Kassube, Nicolas H. Thomä
Published in: Nature Structural & Molecular Biology, Issue 27/8, 2020, Page(s) 735-742, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0454-0

Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

Author(s): Stefano Mattarocci, Julia K Reinert, Richard D Bunker, Gabriele A Fontana, Tianlai Shi, Dominique Klein, Simone Cavadini, Mahamadou Faty, Maksym Shyian, Lukas Hafner, David Shore, Nicolas H Thomä, Ulrich Rass
Published in: Nature Structural & Molecular Biology, Issue 24/7, 2017, Page(s) 588-595, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3420

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

Author(s): Simone Cavadini, Eric S. Fischer, Richard D. Bunker, Alessandro Potenza, Gondichatnahalli M. Lingaraju, Kenneth N. Goldie, Weaam I. Mohamed, Mahamadou Faty, Georg Petzold, Rohan E. J. Beckwith, Ritesh B. Tichkule, Ulrich Hassiepen, Wassim Abdulrahman, Radosav S. Pantelic, Syota Matsumoto, Kaoru Sugasawa, Henning Stahlberg, Nicolas H. Thomä
Published in: Nature, Issue 531/7596, 2016, Page(s) 598-603, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature17416

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

Author(s): Georg Petzold, Eric S. Fischer, Nicolas H. Thomä
Published in: Nature, Issue 532/7597, 2016, Page(s) 127-130, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature16979

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Author(s): Quinlan L. Sievers, Georg Petzold, Richard D. Bunker, Aline Renneville, Mikołaj Słabicki, Brian J. Liddicoat, Wassim Abdulrahman, Tarjei Mikkelsen, Benjamin L. Ebert, Nicolas H. Thomä
Published in: Science, Issue 362/6414, 2018, Page(s) eaat0572, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aat0572

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

Author(s): Julius Rabl, Richard D. Bunker, Andreas D. Schenk, Simone Cavadini, Mark E. Gill, Wassim Abdulrahman, Amparo Andrés-Pons, Martijn S. Luijsterburg, Adel F.M. Ibrahim, Emma Branigan, Jacob D. Aguirre, Aimee H. Marceau, Claire Guérillon, Tewis Bouwmeester, Ulrich Hassiepen, Antoine H.F.M. Peters, Martin Renatus, Laurent Gelman, Seth M. Rubin, Niels Mailand, Haico van Attikum, Ronald T. Hay, Nicolas
Published in: Molecular Cell, Issue 75/3, 2019, Page(s) 483-497.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.06.002