The molecular basis of CULLIN E3 ligase regulation by the COP9 signalosome

Informazioni relative al progetto

CsnCRL

ID dell’accordo di sovvenzione: 666068

DOI 10.3030/666068

Progetto chiuso

Data della firma CE 26 Agosto 2015

Data di avvio 1 Gennaio 2016

Data di completamento 28 Febbraio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 200 677,00

Contributo UE € 2 200 677,00

Coordinato da

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

Pubblicazioni

Peer reviewed articles (10)

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Autori: Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard D. Bunker, Katherine A. Donovan, Quinlan L. Sievers, Jonas Koeppel, Dakota Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä, Benjamin L. E
Pubblicato in: Nature, Numero 585/7824, 2020, Pagina/e 293-297, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2374-x

DNA damage detection in nucleosomes involves DNA register shifting

Autori: Syota Matsumoto, Simone Cavadini, Richard D. Bunker, Ralph S. Grand, Alessandro Potenza, Julius Rabl, Junpei Yamamoto, Andreas D. Schenk, Dirk Schübeler, Shigenori Iwai, Kaoru Sugasawa, Hitoshi Kurumizaka, Nicolas H. Thomä
Pubblicato in: Nature, Numero 571/7763, 2019, Pagina/e 79-84, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1259-3

Structural mechanism of cGAS inhibition by the nucleosome

Autori: Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
Pubblicato in: Nature, Numero 587/7835, 2020, Pagina/e 668-672, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

Mechanisms of OCT4-SOX2 motif readout on nucleosomes

Autori: Alicia K. Michael, Ralph S. Grand, Luke Isbel, Simone Cavadini, Zuzanna Kozicka, Georg Kempf, Richard D. Bunker, Andreas D. Schenk, Alexandra Graff-Meyer, Ganesh R. Pathare, Joscha Weiss, Syota Matsumoto, Lukas Burger, Dirk Schübeler, Nicolas H. Thomä
Pubblicato in: Science, Numero 368/6498, 2020, Pagina/e 1460-1465, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abb0074

Structural insights into Fe–S protein biogenesis by the CIA targeting complex

Autori: Susanne A. Kassube, Nicolas H. Thomä
Pubblicato in: Nature Structural & Molecular Biology, Numero 27/8, 2020, Pagina/e 735-742, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-020-0454-0

Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

Autori: Stefano Mattarocci, Julia K Reinert, Richard D Bunker, Gabriele A Fontana, Tianlai Shi, Dominique Klein, Simone Cavadini, Mahamadou Faty, Maksym Shyian, Lukas Hafner, David Shore, Nicolas H Thomä, Ulrich Rass
Pubblicato in: Nature Structural & Molecular Biology, Numero 24/7, 2017, Pagina/e 588-595, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/nsmb.3420

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

Autori: Simone Cavadini, Eric S. Fischer, Richard D. Bunker, Alessandro Potenza, Gondichatnahalli M. Lingaraju, Kenneth N. Goldie, Weaam I. Mohamed, Mahamadou Faty, Georg Petzold, Rohan E. J. Beckwith, Ritesh B. Tichkule, Ulrich Hassiepen, Wassim Abdulrahman, Radosav S. Pantelic, Syota Matsumoto, Kaoru Sugasawa, Henning Stahlberg, Nicolas H. Thomä
Pubblicato in: Nature, Numero 531/7596, 2016, Pagina/e 598-603, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature17416

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

Autori: Georg Petzold, Eric S. Fischer, Nicolas H. Thomä
Pubblicato in: Nature, Numero 532/7597, 2016, Pagina/e 127-130, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature16979

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Autori: Quinlan L. Sievers, Georg Petzold, Richard D. Bunker, Aline Renneville, Mikołaj Słabicki, Brian J. Liddicoat, Wassim Abdulrahman, Tarjei Mikkelsen, Benjamin L. Ebert, Nicolas H. Thomä
Pubblicato in: Science, Numero 362/6414, 2018, Pagina/e eaat0572, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aat0572

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

Autori: Julius Rabl, Richard D. Bunker, Andreas D. Schenk, Simone Cavadini, Mark E. Gill, Wassim Abdulrahman, Amparo Andrés-Pons, Martijn S. Luijsterburg, Adel F.M. Ibrahim, Emma Branigan, Jacob D. Aguirre, Aimee H. Marceau, Claire Guérillon, Tewis Bouwmeester, Ulrich Hassiepen, Antoine H.F.M. Peters, Martin Renatus, Laurent Gelman, Seth M. Rubin, Niels Mailand, Haico van Attikum, Ronald T. Hay, Nicolas
Pubblicato in: Molecular Cell, Numero 75/3, 2019, Pagina/e 483-497.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.06.002