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Ebola Virus Disease - correlates of protection, determinants of outcome, and clinical management

Objective

The Ebola virus disease (EVD) epidemic in West Africa is not under control. This proposal has immediate, mid-term and long-term objectives to combat the current and future EVD epidemics. Objectives with immediate impact are: (i) Providing key information needed to implement efficient convalescent plasma treatment and a toolkit to determine the suitability of plasma for treatment; (ii) Providing key information needed to estimate the efficacy of experimental vaccines, including correlates of protection at T cell level; (iii) Improving supportive treatment of patients and reducing hospital case fatality rate by providing information on biomarkers and relevant co-infections; (iv) Monitoring development of mutations in Ebola virus (EBOV) genomes during the epidemic and enhancing our preparedness to determine the relevance of these changes in experimental systems; and (v) Protecting health care workers and communities by providing information on virus shedding in body fluids and estimation of infectiousness in various stages of EVD. Objectives with mid to long-term impact are: (i) Provide information on pathophysiological changes and immunological determinants to infer new immunotherapeutic strategies for treatment of EVD; and (ii) Strengthening cooperation of biosafety level 4 (BSL-4) facilities and building a pan-European research area in the field of highly pathogenic viruses as envisaged in the ‘European Research Infrastructure on Highly Pathogenic Agents’ project. The concept of EVIDENT is to scientifically exploit specimens collected from EVD patients during outbreak response and field research. We will use state-of-the-art methodologies within the EU BSL-4 facilities to gather new and outbreak-relevant knowledge on B and T cell immunology, biomarkers, virus evolution, virulence determinants, and transmission of EBOV. The consortium contributes to the outbreak response since March 2014 and is competent to implement a project in the outbreak area.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation/virus mutation
  • /medical and health sciences/health sciences/infectious disease/RNA virus/ebola

Call for proposal

H2020-Adhoc-2014-20
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Germany
Activity type
Research Organisations
EU contribution
€ 481 660,25

Participants (10)

ARTSEN ZONDER GRENZEN (MEDECINS SANS FRONTIERES NEDERLAND) VERENIGING
Netherlands
EU contribution
€ 42 500
Address
Plantage Middenlaan 14
1018 DD Amsterdam
Activity type
Other
Department of Health
United Kingdom
EU contribution
€ 406 943,75
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 226 465
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
BUNDESMINISTERIUM DER VERTEIDIGUNG
Germany
EU contribution
€ 73 625
Address
Fontainengraben 150
53123 Bonn
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 73 625
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
ROBERT KOCH-INSTITUT
Germany
EU contribution
€ 73 437,50
Address
Nordufer 20
13353 Berlin
Activity type
Research Organisations
ORSZAGOS EPIDEMIOLOGIAI KOZPONT
Hungary
EU contribution
€ 72 500
Address
Albert Florian Utca 2-6
1097 Budapest
Activity type
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 72 000
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 73 193,75
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 163 375
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)