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Ebola Virus Disease - correlates of protection, determinants of outcome, and clinical management

Objective

The Ebola virus disease (EVD) epidemic in West Africa is not under control. This proposal has immediate, mid-term and long-term objectives to combat the current and future EVD epidemics. Objectives with immediate impact are: (i) Providing key information needed to implement efficient convalescent plasma treatment and a toolkit to determine the suitability of plasma for treatment; (ii) Providing key information needed to estimate the efficacy of experimental vaccines, including correlates of protection at T cell level; (iii) Improving supportive treatment of patients and reducing hospital case fatality rate by providing information on biomarkers and relevant co-infections; (iv) Monitoring development of mutations in Ebola virus (EBOV) genomes during the epidemic and enhancing our preparedness to determine the relevance of these changes in experimental systems; and (v) Protecting health care workers and communities by providing information on virus shedding in body fluids and estimation of infectiousness in various stages of EVD. Objectives with mid to long-term impact are: (i) Provide information on pathophysiological changes and immunological determinants to infer new immunotherapeutic strategies for treatment of EVD; and (ii) Strengthening cooperation of biosafety level 4 (BSL-4) facilities and building a pan-European research area in the field of highly pathogenic viruses as envisaged in the ‘European Research Infrastructure on Highly Pathogenic Agents’ project. The concept of EVIDENT is to scientifically exploit specimens collected from EVD patients during outbreak response and field research. We will use state-of-the-art methodologies within the EU BSL-4 facilities to gather new and outbreak-relevant knowledge on B and T cell immunology, biomarkers, virus evolution, virulence determinants, and transmission of EBOV. The consortium contributes to the outbreak response since March 2014 and is competent to implement a project in the outbreak area.

Coordinator

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Net EU contribution
€ 481 660,25
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Germany

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Region
Hamburg Hamburg Hamburg
Activity type
Research Organisations
Other funding
€ 0,00

Participants (11)

ARTSEN ZONDER GRENZEN (MEDECINS SANS FRONTIERES NEDERLAND) VERENIGING
Netherlands
Net EU contribution
€ 42 500,00
Address
Plantage Middenlaan 14
1018 DD Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00
Department of Health
United Kingdom
Net EU contribution
€ 226 872,50
Address
Quarry House, Quarry Hill
LS2 7UE Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

THE UNIVERSITY OF LIVERPOOL
United Kingdom
Net EU contribution
€ 180 071,25
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

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Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Net EU contribution
€ 226 465,00
Address
Via Portuense, 292
00149 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 0,00
BUNDESMINISTERIUM DER VERTEIDIGUNG
Germany
Net EU contribution
€ 73 625,00
Address
Fontainengraben 150
53123 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
PHILIPPS UNIVERSITAET MARBURG
Germany
Net EU contribution
€ 73 625,00
Address
Biegenstrasse 10
35037 Marburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ROBERT KOCH-INSTITUT
Germany
Net EU contribution
€ 73 437,50
Address
Nordufer 20
13353 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Other funding
€ 0,00
ORSZAGOS EPIDEMIOLOGIAI KOZPONT
Hungary
Net EU contribution
€ 72 500,00
Address
Albert Florian Utca 2-6
1097 Budapest

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Region
Közép-Magyarország Budapest Budapest
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERZA V LJUBLJANI
Slovenia
Net EU contribution
€ 72 000,00
Address
Kongresni Trg 12
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 73 193,75
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Net EU contribution
€ 163 375,00
Address
Heinrich-hertz-allee 1
66386 St Ingbert

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarpfalz-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00