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Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities

Deliverables

Establishment of external THYRAGE web site

Establishment of external THYRAGE web site

Establishment of the THYRAGE consortium website

Establishment of the THYRAGE consortium website

Final plan for dissemination and exploitation of the project’s results

Final plan for dissemination and exploitation of the project’s results

Searching for OpenAIRE data...

Publications

Influence of thyroid hormone signaling and mitochondrial metabolism on neural stem cell fate in the subventricular zone of adult mice.

Author(s): Jean-David Gothié (tutor: Prof. Barbara Demeneix, Ass. prof. Sylvie Remaud)
Published in: 2017, Page(s) all

Thyroid hormone action in the central nervous system and peripheral tissues

Author(s): Petra Mohácsik (Tutor: B Gereben)
Published in: 2017, Page(s) all

Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study

Author(s): Nicolien A van Vliet, Raymond Noordam, Jan B van Klinken, Rudi GJ Westendorp, JH Duncan Bassett, Graham R Williams, Diana van Heemst
Published in: Journal of Bone and Mineral Research, Issue 33/7, 2018, Page(s) 1318-1325, ISSN 0884-0431
DOI: 10.1002/jbmr.3426

Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism

Author(s): J.D. Gothié, A. Sébillot, C. Luongo, M. Legendre, C. Nguyen Van, K. Le Blay, M. Perret-Jeanneret, S. Remaud, B.A. Demeneix
Published in: Molecular Metabolism, Issue 6/11, 2017, Page(s) 1551-1561, ISSN 2212-8778
DOI: 10.1016/j.molmet.2017.08.003

Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

Author(s): Remaud , Sylvie; Ortiz , Fernando ,; Perret-Jeanneret , Marine; Aigrot , Marie-Stéphane; Gothié , Jean-David; Fekete , Csaba; Kvárta-Papp , Zsuzsanna; Gereben , Balázs; Langui , Dominique; Lubetzki , Catherine; Angulo , Maria ,; Zalc , Bernard; Demeneix , Barbara
Published in: "eLife, eLife Sciences Publication, 2017, 6, pp.e29996. 〈10.7554/eLife.29996.001〉", Issue 1, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.29996.001

Thyroid status and mortality in nonagenarians from long-lived families and the general population

Author(s): Nicolien A. van Vliet, Evie van der Spoel, Marian Beekman, P. Eline Slagboom, Gerard Jan Blauw, Jacobijn Gussekloo, Rudi G.J. Westendorp, Diana van Heemst
Published in: Aging, Issue 9/10, 2017, Page(s) 2223-2234, ISSN 1945-4589
DOI: 10.18632/aging.101310

Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Author(s): Sungro Jo, Tatiana L. Fonseca, Barbara M. L. C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Anaysa P. Bolin, Rodrigo R. Da Conceição, Joao Pedro Werneck-de-Castro, Daniele L. Ignacio, Péter Egri, Dorottya Németh, Csaba Fekete, Maria Martha Bernardi, Victoria D. Leitch, Naila S. Mannan, Katharine F. Curry, Natalie C. Butterfield, J.H. Duncan Bassett, Graham R. Williams, Balázs Gereben,
Published in: Journal of Clinical Investigation, Issue 129/1, 2019, Page(s) 230-245, ISSN 0021-9738
DOI: 10.1172/jci123176

The 24-hour serum profiles of bone markers in healthy older men and women

Author(s): Evie van der Spoel, Nicole Oei, Ricardo Cachucho, Ferdinand Roelfsema, Jimmy F.P. Berbée, Gerard J. Blauw, Hanno Pijl, Natasha M. Appelman-Dijkstra, Diana van Heemst
Published in: Bone, Issue 120, 2019, Page(s) 61-69, ISSN 8756-3282
DOI: 10.1016/j.bone.2018.10.002

Thyroid diseases and bone health

Author(s): G. R. Williams, J. H. D. Bassett
Published in: Journal of Endocrinological Investigation, Issue 41/1, 2018, Page(s) 99-109, ISSN 1720-8386
DOI: 10.1007/s40618-017-0753-4

Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse

Author(s): Pieter Vancamp, Jean-David Gothié, Cristina Luongo, Anthony Sébillot, Karine Le Blay, Lucile Butruille, Maurice Pagnin, Samantha J. Richardson, Barbara A. Demeneix, Sylvie Remaud
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-56156-w

Thyroid hormone regulation of neural stem cell fate: From development to ageing

Author(s): Jean‐David Gothié, Pieter Vancamp, Barbara Demeneix, Sylvie Remaud
Published in: Acta Physiologica, Issue 228/1, 2019, ISSN 1748-1708
DOI: 10.1111/apha.13316

Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data

Author(s): Evie van der Spoel, Jungyeon Choi, Ferdinand Roelfsema, Saskia le Cessie, Diana van Heemst, Olaf M. Dekkers
Published in: Journal of Biological Rhythms, Issue 34/4, 2019, Page(s) 347-363, ISSN 0748-7304
DOI: 10.1177/0748730419850917

Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance

Author(s): Evie van der Spoel, Nicolien A. van Vliet, Diana van Heemst
Published in: Ageing Research Reviews, Issue 56, 2019, Page(s) 100964, ISSN 1568-1637
DOI: 10.1016/j.arr.2019.100964

The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress

Author(s): Serena Sagliocchi, Annunziata Gaetana Cicatiello, Emery Di Cicco, Raffaele Ambrosio, Caterina Miro, Daniela Di Girolamo, Annarita Nappi, Giuseppina Mancino, Maria Angela De Stefano, Cristina Luongo, Maddalena Raia, Ashley N. Ogawa-Wong, Ann Marie Zavacki, Simona Paladino, Domenico Salvatore, Monica Dentice
Published in: Redox Biology, Issue 24, 2019, Page(s) 101228, ISSN 2213-2317
DOI: 10.1016/j.redox.2019.101228

PYY is a negative regulator of bone mass and strength

Author(s): Victoria D. Leitch, Mary Jane Brassill, Sofia Rahman, Natalie C. Butterfield, Pattara Ma, John G. Logan, Alan Boyde, Holly Evans, Peter I. Croucher, Rachel L. Batterham, Graham R. Williams, J.H. Duncan Bassett
Published in: Bone, Issue 127, 2019, Page(s) 427-435, ISSN 8756-3282
DOI: 10.1016/j.bone.2019.07.011

Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

Author(s): Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, Monica Dentice
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-13140-2

An essential physiological role for MCT8 in bone in male mice

Author(s): Victoria D. Leitch, Caterina Di Cosmo, Xiao-Hui Liao, Sam O'Boy, Thomas M. Galliford, Holly Evans, Peter I. Croucher, Alan Boyde, Alexandra Dumitrescu, Roy E. Weiss, Samuel Refetoff, Graham R. Williams, J.H. Duncan Bassett
Published in: Endocrinology, Issue en.2017-00399, 2017, Page(s) In Press, ISSN 0013-7227
DOI: 10.1210/en.2017-00399

Comparative approaches to understanding thyroid hormone regulation of neurogenesis

Author(s): Jean-David Gothié, Barbara Demeneix, Sylvie Remaud
Published in: Molecular and Cellular Endocrinology, 2017, Page(s) S0303-7207(17)30289-7, ISSN 0303-7207
DOI: 10.1016/j.mce.2017.05.020

Hungarian: Az alacsony T3 szindróma kialakulásának idegrendszeri mechanizmusai English: Nervous system related mechanism underlying the development of the Low T3 Syndrome

Author(s): Balázs Gereben, Csaba Fekete
Published in: Magyar Belorvosi Archivum, Issue 2016. 69. (2-3)., 2016, Page(s) 76-82, ISSN 0133-5464

Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight

Author(s): Saira Hameed, Michael Patterson, Waljit S. Dhillo, Sofia A. Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles S.H. Yeo, Brian Y.H. Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R. Bloom, J.H. Duncan Bassett, Graham R. Williams, James V. Gardiner
Published in: Cell Reports, Issue 19/11, 2017, Page(s) 2202-2209, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.05.066

The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas

Author(s): Annarita Nappi, Emery Di Cicco, Caterina Miro, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Giuseppina Mancino, Raffaele Ambrosio, Cristina Luongo, Daniela Di Girolamo, Maria Angela De Stefano, Tommaso Porcelli, Mariano Stornaiuolo, Monica Dentice
Published in: Cancers, Issue 12/3, 2020, Page(s) 715, ISSN 2072-6694
DOI: 10.3390/cancers12030715

The Thyroid Hormone Inactivator Enzyme, Type 3 Deiodinase, Is Essential for Coordination of Keratinocyte Growth and Differentiation

Author(s): Giuseppina Mancino, Annarita Sibilio, Cristina Luongo, Emery Di Cicco, Caterina Miro, Annunziata Gaetana Cicatiello, Annarita Nappi, Serena Sagliocchi, Raffaele Ambrosio, Maria Angela De Stefano, Daniela Di Girolamo, Tommaso Porcelli, Melania Murolo, Federica Saracino, Giuseppe Perruolo, Pietro Formisano, Mariano Stornaiuolo, Monica Dentice
Published in: Thyroid, Issue 30/7, 2020, Page(s) 1066-1078, ISSN 1050-7256
DOI: 10.1089/thy.2019.0557

A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System

Author(s): Erzsébet Farkas, Edina Varga, Balázs Kovács, Anett Szilvásy-Szabó, Antonieta Cote-Vélez, Zoltán Péterfi, Magdalini Matziari, Mónika Tóth, Dóra Zelena, Zsolt Mezriczky, Andrea Kádár, Dóra Kővári, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balázs Rózsa, Yvette Ruska, Blanka Tóth, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Balázs Gereben, Ronald M. Lechan, Jean-Louis Charl
Published in: iScience, Issue 23/3, 2020, Page(s) 100921, ISSN 2589-0042
DOI: 10.1016/j.isci.2020.100921

Thyrotropin-Releasing-Hormone-Synthesizing Neurons of the Hypothalamic Paraventricular Nucleus Are Inhibited by Glycinergic Inputs

Author(s): Edina Varga, Erzsébet Farkas, Györgyi Zséli, Andrea Kádár, Alexandra Venczel, Dóra Kővári, Dorottya Németh, Zoltán Máté, Ferenc Erdélyi, András Horváth, Ottó Szenci, Masahiko Watanabe, Ronald M. Lechan, Balázs Gereben, Csaba Fekete
Published in: Thyroid, Issue 29/12, 2019, Page(s) 1858-1868, ISSN 1050-7256
DOI: 10.1089/thy.2019.0357

Deiodinases and their intricate role in thyroid hormone homeostasis

Author(s): Cristina Luongo, Monica Dentice, Domenico Salvatore
Published in: Nature Reviews Endocrinology, Issue 15/8, 2019, Page(s) 479-488, ISSN 1759-5029
DOI: 10.1038/s41574-019-0218-2

Paradigms of Dynamic Control of Thyroid Hormone Signaling

Author(s): Antonio C Bianco, Alexandra Dumitrescu, Balázs Gereben, Miriam O Ribeiro, Tatiana L Fonseca, Gustavo W Fernandes, Barbara M L C Bocco
Published in: Endocrine Reviews, Issue 40/4, 2019, Page(s) 1000-1047, ISSN 0163-769X
DOI: 10.1210/er.2018-00275

Accelerating functional gene discovery in osteoarthritis

Author(s): Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Anto
Published in: BioRxiv, Issue Posted November 10, 2019., 2019
DOI: 10.1101/836221

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease

Author(s): Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana
Published in: BioRxiv, Issue Posted April 22, 2020., 2020
DOI: 10.1101/2020.04.20.051409

Decoding the genomic basis of osteoarthritis

Author(s): Julia Steinberg, Lorraine Southam, Natalie C Butterfield, Theodoros I Roumeliotis, Andreas Fontalis, Matthew J Clark, Raveen L Jayasuriya, Diane Swift, Karan M Shah, Katherine F Curry, Roger A Brooks, Andrew W McCaskie, Christopher J. Lelliott, Jyoti S Choudhary, JH Duncan Bassett, Graham R Williams, J Mark Wilkinson, Eleftheria Zeggini
Published in: BioRxiv, Issue Posted January 31, 2020, 2020
DOI: 10.1101/835850