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Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Deliverables

Individualized press release for every partner

Individualized press release for every partner

Initial Dissemination plan

Initial Dissemination plan

Launch of website, Twitter and LinkedIn account

Launch of website, Twitter and LinkedIn account

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Publications

Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis

Author(s): Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw
Published in: PLOS ONE, Issue 13/7, 2018, Page(s) e0200525, ISSN 1932-6203
DOI: 10.1371/journal.pone.0200525

Time course of blood pressure control prior to lacunar TIA and stroke


Published in: ISSN 0028-3878
DOI: 10.1212/WNL.0000000000005526

Vascular reactivity in small cerebral perforating arteries with 7 T phase contrast MRI – A proof of concept study

Author(s): Lennart J. Geurts, Alex A. Bhogal, Jeroen C.W. Siero, Peter R. Luijten, Geert Jan Biessels, Jaco J.M. Zwanenburg
Published in: NeuroImage, Issue 172, 2018, Page(s) 470-477, ISSN 1053-8119
DOI: 10.1016/j.neuroimage.2018.01.055

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

Author(s): Stephen DJ Makin, Fergus N Doubal, Terence J Quinn, Philip MW Bath, Martin S Dennis, Joanna M Wardlaw
Published in: European Stroke Journal, Issue 3/1, 2017, Page(s) 66-73, ISSN 2396-9873
DOI: 10.1177/2396987317728854

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000006851

MRI measurement of blood-brain barrier leakage: minding the gaps

Author(s): Michael Jonathan Thrippleton
Published in: The Journal of Physiology, Issue 597/3, 2019, Page(s) 667-668, ISSN 0022-3751
DOI: 10.1113/jp277425

Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review

Author(s): Yulu Shi, Michael J. Thrippleton, Ian Marshall, Joanna M. Wardlaw
Published in: Clinical Science, Issue 132/1, 2018, Page(s) 157-171, ISSN 0143-5221
DOI: 10.1042/cs20171280

Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing

Author(s): Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter JD Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw
Published in: International Journal of Stroke, Issue 13/2, 2017, Page(s) 195-206, ISSN 1747-4930
DOI: 10.1177/1747493017730740

A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

Author(s): Catherine A Humphreys, Maurits A Jansen, Susana Muñoz Maniega, Víctor González-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith
Published in: International Journal of Stroke, 2018, Page(s) 174749301879996, ISSN 1747-4930
DOI: 10.1177/1747493018799962

Age and sex-specific associations of carotid pulsatility with small vessel disease burden in transient ischemic attack and ischemic stroke

Author(s): Kui Kai Lau, Petra Pego, Sara Mazzucco, Linxin Li, Dominic PJ Howard, Wilhelm Küker, Peter M Rothwell
Published in: International Journal of Stroke, Issue 13/8, 2018, Page(s) 832-839, ISSN 1747-4930
DOI: 10.1177/1747493018784448

MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease

Author(s): Michael Thrippleton, Gordon Blair, Maria Valdes-Hernandez, Andreas Glatz, Scott Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David Newby, Joanna Wardlaw
Published in: International Journal of Molecular Sciences, Issue 20/3, 2019, Page(s) 776, ISSN 1422-0067
DOI: 10.3390/ijms20030776

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

Author(s): Benjamin A. Plog, Maiken Nedergaard
Published in: Annual Review of Pathology: Mechanisms of Disease, Issue 13/1, 2018, Page(s) 379-394, ISSN 1553-4006
DOI: 10.1146/annurev-pathol-051217-111018

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis

Author(s): Farah Francis, Lucia Ballerini, Joanna M Wardlaw
Published in: International Journal of Stroke, 2019, Page(s) 174749301983032, ISSN 1747-4930
DOI: 10.1177/1747493019830321

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease

Author(s): Emma L. Bailey, Martin W. McBride, John D. McClure, Wendy Beattie, Delyth Graham, Anna F. Dominiczak, Colin Smith, Joanna M. Wardlaw
Published in: Clinical Science, Issue 132/12, 2018, Page(s) 1315-1328, ISSN 0143-5221
DOI: 10.1042/cs20171572

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Author(s): Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07318-3

Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination

Author(s): Gordon W Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael J Thrippleton, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw
Published in: International Journal of Stroke, Issue 13/5, 2017, Page(s) 530-538, ISSN 1747-4930
DOI: 10.1177/1747493017731947

Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology

Author(s): Alice M Harper, Lauren Clayson, Joanna M Wardlaw, Maria del C Valdés Hernández
Published in: Journal of International Medical Research, Issue 46/9, 2018, Page(s) 3518-3538, ISSN 0300-0605
DOI: 10.1177/0300060518755623

Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936

Author(s): Simon R. Cox, Mike Allerhand, Stuart J. Ritchie, Susana Muñoz Maniega, Maria Valdés Hernández, Sarah E. Harris, David Alexander Dickie, Devasuda Anblagan, Benjamin S. Aribisala, Zoe Morris, Roy Sherwood, N. Joan Abbott, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary
Published in: Neurobiology of Aging, Issue 69, 2018, Page(s) 274-282, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.05.029

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

Author(s): Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/elife.38689

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

Author(s): Caroline MJ Loos, Caroline McHutchison, Vera Cvoro, Stephen DJ Makin, Julie Staals, Francesca Chappell, Martin S Dennis, Robert J van Oostenbrugge, Joanna M Wardlaw
Published in: International Journal of Stroke, Issue 13/5, 2017, Page(s) 518-524, ISSN 1747-4930
DOI: 10.1177/1747493017730780

Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension

Author(s): Renske Uiterwijk, Julie Staals, Marjolein Huijts, Sander M. J. van Kuijk, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge
Published in: The Journal of Clinical Hypertension, Issue 20/10, 2018, Page(s) 1458-1463, ISSN 1524-6175
DOI: 10.1111/jch.13372

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke


Published in: ISSN 0009-7322
DOI: 10.1161/circulationaha.118.035905

Dementia risk after transient ischaemic attack and stroke

Author(s): Martin Dichgans
Published in: The Lancet Neurology, Issue 18/3, 2019, Page(s) 223-225, ISSN 1474-4422
DOI: 10.1016/s1474-4422(18)30497-6

Role of Non-Coding RNAs in Stroke


Published in: ISSN 0039-2499
DOI: 10.1161/strokeaha.118.021010

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Author(s): Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad
Published in: Nature Genetics, Issue 50/4, 2018, Page(s) 524-537, ISSN 1061-4036
DOI: 10.1038/s41588-018-0058-3

CADASIL brain vessels show a HTRA1 loss-of-function profile

Author(s): Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. Müller, Martin Dichgans, Christof Haffner
Published in: Acta Neuropathologica, Issue 136/1, 2018, Page(s) 111-125, ISSN 0001-6322
DOI: 10.1007/s00401-018-1853-8

Serum neurofilament light


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000006282

Challenges and opportunities in stroke genetics

Author(s): Rainer Malik, Martin Dichgans
Published in: Cardiovascular Research, Issue Vol. 114, Issue 9, 2018, Page(s) 1226-1240, ISSN 0008-6363
DOI: 10.1093/cvr/cvy068

COL4A2 is associated with lacunar ischemic stroke and deep ICH


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000004560

Smooth muscle cells of intracranial vessels: from development to disease

Author(s): Juhana Frösen, Anne Joutel
Published in: Cardiovascular Research, Issue 114/4, 2018, Page(s) 501-512, ISSN 0008-6363
DOI: 10.1093/cvr/cvy002

Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging

Author(s): C. Eleana Zhang, Sau May Wong, Renske Uiterwijk, Walter H. Backes, Jacobus F. A. Jansen, Cécile R. L. P. N. Jeukens, Robert J. van Oostenbrugge, Julie Staals
Published in: Brain Imaging and Behavior, Issue 13/2, 2019, Page(s) 389-395, ISSN 1931-7557
DOI: 10.1007/s11682-018-9855-7

Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

Author(s): Qianliang Li, Nadia N. Aalling, Benjamin Förstera, Ali Ertürk, Maiken Nedergaard, Kjeld Møllgård, Anna L. R. Xavier
Published in: Fluids and Barriers of the CNS, Issue 17/1, 2020, ISSN 2045-8118
DOI: 10.1186/s12987-020-0176-z

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

Author(s): David Alexander Dickie, Maria del C Valdés Hernández, Stephen D Makin, Julie Staals, Stewart J Wiseman, Mark E Bastin, Joanna M Wardlaw
Published in: International Journal of Stroke, Issue 13/8, 2018, Page(s) 849-856, ISSN 1747-4930
DOI: 10.1177/1747493018770222

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)


Published in: ISSN 2352-8729
DOI: 10.17863/CAM.43337

Intracranial hemodynamic relationships in patients with cerebral small vessel disease


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000009483

The Brain’s Glymphatic System: Current Controversies

Author(s): Humberto Mestre, Yuki Mori, Maiken Nedergaard
Published in: Trends in Neurosciences, Issue TINS 1601 No. of Pages 9, 2020, ISSN 0166-2236
DOI: 10.1016/j.tins.2020.04.003

Intravoxel Incoherent Motion Imaging in Small Vessel Disease


Published in: ISSN 0039-2499
DOI: 10.1161/STROKEAHA.116.015084

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

Author(s): Thomas Dalsgaard, Swapnil K. Sonkusare, Cory Teuscher, Matthew E. Poynter, Mark T. Nelson
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep33841

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

Author(s): Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff, Maiken Nedergaard
Published in: The Journal of Neuroscience, Issue 37/11, 2017, Page(s) 2870-2877, ISSN 0270-6474
DOI: 10.1523/JNEUROSCI.2112-16.2017

Vascular disease and neurodegeneration: advancing together

Author(s): The Lancet Neurology
Published in: The Lancet Neurology, Issue 16/5, 2017, Page(s) 333, ISSN 1474-4422
DOI: 10.1016/S1474-4422(17)30086-8

Vascular Cognitive Impairment


Published in: ISSN 0009-7330
DOI: 10.1161/CIRCRESAHA.116.308426

Prediction of 3-year clinical course in CADASIL


Published in: ISSN 0028-3878
DOI: 10.1212/WNL.0000000000003252

Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators

Author(s): Swapnil K. Sonkusare, Thomas Dalsgaard, Adrian D. Bonev, Mark T. Nelson
Published in: The Journal of Physiology, Issue 594/12, 2016, Page(s) 3271-3285, ISSN 0022-3751
DOI: 10.1113/JP271652

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

Author(s): Chenchen Pan, Ruiyao Cai, Francesca Paola Quacquarelli, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, Paweł Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali Ertürk
Published in: Nature Methods, Issue 13/10, 2016, Page(s) 859-867, ISSN 1548-7091
DOI: 10.1038/nmeth.3964

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

Author(s): Thomas A Longden, Fabrice Dabertrand, Masayo Koide, Albert L Gonzales, Nathan R Tykocki, Joseph E Brayden, David Hill-Eubanks, Mark T Nelson
Published in: Nature Neuroscience, Issue 20/5, 2017, Page(s) 717-726, ISSN 1097-6256
DOI: 10.1038/nn.4533

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

Author(s): Carmen Capone, Fabrice Dabertrand, Celine Baron-Menguy, Athena Chalaris, Lamia Ghezali, Valérie Domenga-Denier, Stefanie Schmidt, Clément Huneau, Stefan Rose-John, Mark T Nelson, Anne Joutel
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
DOI: 10.7554/eLife.17536

Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

Author(s): Virginia E Hawkins, Ana C Takakura, Ashley Trinh, Milene R Malheiros-Lima, Colin M Cleary, Ian C Wenker, Todd Dubreuil, Elliot M Rodriguez, Mark T Nelson, Thiago S Moreira, Daniel K Mulkey
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.25232

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

Author(s): K. Khavandi, R. L. Baylie, S. A. Sugden, M. Ahmed, V. Csato, P. Eaton, D. C. Hill-Eubanks, A. D. Bonev, M. T. Nelson, A. S. Greenstein
Published in: Science Signaling, Issue 9/449, 2016, Page(s) ra100-ra100, ISSN 1937-9145
DOI: 10.1126/scisignal.aaf6625

Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension

Author(s): Renske Uiterwijk, Robert J. van Oostenbrugge, Marjolein Huijts, Peter W. De Leeuw, Abraham A. Kroon, Julie Staals
Published in: Frontiers in Aging Neuroscience, Issue 8, 2016, ISSN 1663-4365
DOI: 10.3389/fnagi.2016.00301

Detection, risk factors, and functional consequences of cerebral microinfarcts

Author(s): Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels
Published in: The Lancet Neurology, 2017, ISSN 1474-4422
DOI: 10.1016/S1474-4422(17)30196-5

Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms

Author(s): Anne Joutel, Hugues Chabriat
Published in: Clinical Science, Issue 131/8, 2017, Page(s) 635-651, ISSN 0143-5221
DOI: 10.1042/CS20160380

Advanced Neuroimaging of Cerebral Small Vessel Disease

Author(s): Gordon W. Blair, Maria Valdez Hernandez, Michael J. Thrippleton, Fergus N. Doubal, Joanna M. Wardlaw
Published in: Current Treatment Options in Cardiovascular Medicine, Issue 19/7, 2017, ISSN 1092-8464
DOI: 10.1007/s11936-017-0555-1

Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life


Published in: ISSN 1044-3983
DOI: 10.1097/EDE.0000000000000675

Early life risk factors for cerebrovascular disease


Published in: ISSN 0028-3878
DOI: 10.1212/WNL.0000000000003687

Application of Texture Analysis to Study Small Vessel Disease and Blood–Brain Barrier Integrity

Author(s): Maria del C. Valdés Hernández, Victor González-Castro, Francesca M. Chappell, Eleni Sakka, Stephen Makin, Paul A. Armitage, William H. Nailon, Joanna M. Wardlaw
Published in: Frontiers in Neurology, Issue 8, 2017, ISSN 1664-2295
DOI: 10.3389/fneur.2017.00327

Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

Author(s): Francesca M. Chappell, Maria del Carmen Valdés Hernández, Stephen D. Makin, Kirsten Shuler, Eleni Sakka, Martin S. Dennis, Paul A. Armitage, Susana Muñoz Maniega, Joanna M. Wardlaw
Published in: Trials, Issue 18/1, 2017, ISSN 1745-6215
DOI: 10.1186/s13063-017-1825-7

Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance

Author(s): Víctor González-Castro, María del C. Valdés Hernández, Francesca M. Chappell, Paul A. Armitage, Stephen Makin, Joanna M. Wardlaw
Published in: Clinical Science, Issue 131/13, 2017, Page(s) 1465-1481, ISSN 0143-5221
DOI: 10.1042/CS20170051

White matter hyperintensity reduction and outcomes after minor stroke


Published in: ISSN 0028-3878
DOI: 10.1212/WNL.0000000000004328

Genetic variation at 16q24.2 is associated with small vessel stroke


Published in: ISSN 0364-5134
DOI: 10.1002/ana.24840

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms


Published in: ISSN 0039-2499
DOI: 10.1161/STROKEAHA.116.016198

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Author(s): Amanda M Sweeney, Virginia Plá, Ting Du, Guojun Liu, Qian Sun, Sisi Peng, Benjamin A. Plog, Benjamin T. Kress, Xiaowei Wang, Humberto Mestre, Maiken Nedergaard
Published in: Journal of Visualized Experiments, Issue 149, 2019, Page(s) e59774, ISSN 1940-087X
DOI: 10.3791/59774

Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding

Author(s): Vaanathi Sundaresan, Giovanna Zamboni, Campbell Le Heron, Peter M. Rothwell, Masud Husain, Marco Battaglini, Nicola De Stefano, Mark Jenkinson, Ludovica Griffanti
Published in: NeuroImage, Issue 202, 2019, Page(s) 116056, ISSN 1053-8119
DOI: 10.1016/j.neuroimage.2019.116056

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Author(s): Susana Muñoz Maniega, Rozanna Meijboom, Francesca M. Chappell, Maria del C. Valdés Hernández, John M. Starr, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Published in: Frontiers in Neurology, Issue 10, 2019, Page(s) 784, ISSN 1664-2295
DOI: 10.3389/fneur.2019.00784

“A Step and a Ceiling”: mechanical properties of Ca 2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG

Author(s): Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein
Published in: Physiological Reports, Issue 7/22, 2019, Page(s) e14260, ISSN 2051-817X
DOI: 10.14814/phy2.14260

Predictors of Lesion Cavitation After Recent Small Subcortical Stroke

Author(s): Thomas Gattringer, Maria Valdes Hernandez, Anna Heye, Paul A Armitage, Stephen Makin, Francesca Chappell, Daniela Pinter, Fergus Doubal, Christian Enzinger, Franz Fazekas, Joanna M. Wardlaw
Published in: Translational Stroke Research, Issue 11/3, 2020, Page(s) 402-411, ISSN 1868-4483
DOI: 10.1007/s12975-019-00741-8

Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment

Author(s): Chenxing Eleana Zhang, Julie Staals, Robert Jan van Oostenbrugge, Hans Vink
Published in: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295
DOI: 10.3389/fneur.2019.01268

A prospective study of serum metabolites and risk of ischemic stroke


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000007279

Prognostic value of “tissue-based” definitions of TIA and minor stroke


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000007531

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke


Published in: ISSN 0039-2499
DOI: 10.1161/STROKEAHA.118.024181

Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability

Author(s): Caroline A. McHutchison, Francesca M. Chappell, Stephen Makin, Kirsten Shuler, Joanna M. Wardlaw, Vera Cvoro
Published in: Brain Sciences, Issue 9/5, 2019, Page(s) 117, ISSN 2076-3425
DOI: 10.3390/brainsci9050117

Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition

Author(s): Maria del C. Valdés Hernández, Lucia Ballerini, Andreas Glatz, Susana Muñoz Maniega, Alan J. Gow, Mark E. Bastin, John M. Starr, Ian J. Deary, Joanna M. Wardlaw
Published in: Brain Imaging and Behavior, Issue 27-June 2019, 2019, ISSN 1931-7557
DOI: 10.1007/s11682-019-00128-1

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

Author(s): Minghuan Wang, Chuan Qin, Xiang Luo, Jie Wang, Xuxia Wang, Minjie Xie, Jing Hu, Jie Cao, Ting Hu, Steven A. Goldman, Maiken Nedergaard, Wei Wang
Published in: Theranostics, Issue 9/15, 2019, Page(s) 4474-4493, ISSN 1838-7640
DOI: 10.7150/thno.31942

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects


Published in: ISSN 0009-7322
DOI: 10.1161/circulationaha.118.038814

Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial

Author(s): Gordon W. Blair, Jason P. Appleton, Katie Flaherty, Fergus Doubal, Nikola Sprigg, Richard Dooley, Carla Richardson, Iona Hamilton, Zhe Kang Law, Yulu Shi, Michael S. Stringer, Michael J. Thrippleton, Julia Boyd, Kirsten Shuler, Philip M. Bath, Joanna M. Wardlaw
Published in: EClinicalMedicine, Issue 11, 2019, Page(s) 34-43, ISSN 2589-5370
DOI: 10.1016/j.eclinm.2019.04.001

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial

Author(s): Jason P. Appleton, Gordon W. Blair, Katie Flaherty, Zhe Kang Law, Jane May, Lisa J. Woodhouse, Fergus Doubal, Nikola Sprigg, Philip M. Bath, Joanna M. Wardlaw
Published in: Frontiers in Neurology, Issue 10, 2019, Page(s) 723, ISSN 1664-2295
DOI: 10.3389/fneur.2019.00723

Vascular Cognitive Impairment and Dementia

Author(s): Costantino Iadecola, Marco Duering, Vladimir Hachinski, Anne Joutel, Sarah T. Pendlebury, Julie A. Schneider, Martin Dichgans
Published in: Journal of the American College of Cardiology, Issue 73/25, 2019, Page(s) 3326-3344, ISSN 0735-1097
DOI: 10.1016/j.jacc.2019.04.034

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

Author(s): Kristian Nygaard Mortensen, Simon Sanggaard, Humberto Mestre, Hedok Lee, Serhii Kostrikov, Anna L.R. Xavier, Albert Gjedde, Helene Benveniste, Maiken Nedergaard
Published in: The Journal of Neuroscience, Issue 39/32, 2019, Page(s) 6365-6377, ISSN 0270-6474
DOI: 10.1523/jneurosci.1974-18.2019

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Author(s): Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 1-10, ISSN 2041-1723
DOI: 10.1038/s41467-019-13848-1

Sleep and brain morphological changes in the eighth decade of life

Author(s): Benjamin S. Aribisala, Renata L. Riha, Maria Valdes Hernandez, Susana Muñoz Maniega, Simon Cox, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, John Starr, Ian Deary, Joanna M. Wardlaw
Published in: Sleep Medicine, Issue 65, 2020, Page(s) 152-158, ISSN 1389-9457
DOI: 10.1016/j.sleep.2019.07.015

Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

Author(s): Jose Bernal, Maria del C. Valdés-Hernández, Javier Escudero, Linda Viksne, Anna K. Heye, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Published in: Magnetic Resonance Imaging, Issue 66, 2020, Page(s) 240-247, ISSN 0730-725X
DOI: 10.1016/j.mri.2019.11.001

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Author(s): Jacob Jan Sloots, Geert Jan Biessels, Jaco J.M. Zwanenburg
Published in: NeuroImage, Issue 210, 2020, Page(s) 116581, ISSN 1053-8119
DOI: 10.1016/j.neuroimage.2020.116581

Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke

Author(s): Maria Valdés Hernández, Tessa Case, Francesca Chappell, Andreas Glatz, Stephen Makin, Fergus Doubal, Joanna Wardlaw
Published in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1293, ISSN 1422-0067
DOI: 10.3390/ijms20061293

WMH and long-term outcomes in ischemic stroke


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000007142

Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

Author(s): Lucia Ballerini, Tom Booth, Maria del C. Valdés Hernández, Stewart Wiseman, Ruggiero Lovreglio, Susana Muñoz Maniega, Zoe Morris, Alison Pattie, Janie Corley, Alan Gow, Mark E. Bastin, Ian J. Deary, Joanna Wardlaw
Published in: NeuroImage: Clinical, Issue 25, 2020, Page(s) 102120, ISSN 2213-1582
DOI: 10.1016/j.nicl.2019.102120

Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000008881

Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease

Author(s): Joanna Wardlaw, Philip M W Bath, Fergus Doubal, Anna Heye, Nikola Sprigg, Lisa J Woodhouse, Gordon Blair, Jason Appleton, Vera Cvoro, Timothy England, Ahamad Hassan, David John Werring, Alan Montgomery
Published in: European Stroke Journal, Issue April 2020, 2020, Page(s) 239698732092011, ISSN 2396-9873
DOI: 10.1177/2396987320920110

Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks

Author(s): Muhammad Febrian Rachmadi, Maria del C. Valdés-Hernández, Stephen Makin, Joanna Wardlaw, Taku Komura
Published in: Medical Image Analysis, Issue 63, 2020, Page(s) 101712, ISSN 1361-8415
DOI: 10.1016/j.media.2020.101712

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases


Published in: ISSN 0039-2499
DOI: 10.1161/strokeaha.120.029163

Examining the Relationship between Semiquantitative Methods Analysing Concentration-Time and Enhancement-Time Curves from Dynamic-Contrast Enhanced Magnetic Resonance Imaging and Cerebrovascular Dysfunction in Small Vessel Disease

Author(s): Jose Bernal, María Valdés-Hernández, Javier Escudero, Eleni Sakka, Paul A. Armitage, Stephen Makin, Rhian M. Touyz, Joanna M. Wardlaw
Published in: Journal of Imaging, Issue 6/6, 2020, Page(s) 43, ISSN 2313-433X
DOI: 10.3390/jimaging6060043

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Author(s): Una Clancy, Daniela Jaime Garcia, Michael S Stringer, Michael J Thrippleton, Maria C Valdés-Hernández, Stewart Wiseman, Olivia KL Hamilton, Francesca M Chappell, Rosalind Brown, Gordon W Blair, Will Hewins, Emilie Sleight, Lucia Ballerini, Mark E Bastin, Susana Munoz Maniega, Tom MacGillivray, Kirstie Hetherington, Charlene Hamid, Carmen Arteaga, Alasdair G Morgan, Cameron Manning, Ellen Backhou
Published in: European Stroke Journal, 2020, Page(s) 239698732092961, ISSN 2396-9873
DOI: 10.1177/2396987320929617

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Author(s): Marios K Georgakis, Rainer Malik, Christopher D Anderson, Klaus G Parhofer, Jemma C Hopewell, Martin Dichgans
Published in: Brain, Issue 143/2, 2020, Page(s) 597-610, ISSN 0006-8950
DOI: 10.1093/brain/awz413

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes

Author(s): Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie L. M. Sudlow, Martin Dichgans, Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Daniel I. Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri L. Wiggins, James MacDonald, Si
Published in: Circulation: Genomic and Precision Medicine, Issue 13/3, 2020, Page(s) e002872, ISSN 2574-8300
DOI: 10.1161/circgen.119.002872

Stroke genetics: discovery, biology, and clinical applications

Author(s): Martin Dichgans, Sara L Pulit, Jonathan Rosand
Published in: The Lancet Neurology, Issue 18/6, 2019, Page(s) 587-599, ISSN 1474-4422
DOI: 10.1016/S1474-4422(19)30043-2

Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy


Published in: ISSN 0028-3878
DOI: 10.1212/wnl.0000000000006956

Preventing dementia by preventing stroke: The Berlin Manifesto


Published in: ISSN 1552-5260
DOI: 10.1016/j.jalz.2019.06.001

Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia

Author(s): Takashi Koizumi, Danielle Kerkhofs, Toshiki Mizuno, Harry W. M. Steinbusch, Sébastien Foulquier
Published in: Frontiers in Neuroscience, Issue 13, 2019, Page(s) 1291, ISSN 1662-453X
DOI: 10.3389/fnins.2019.01291

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke


Published in: ISSN 0009-7330
DOI: 10.1161/CIRCRESAHA.119.315380