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The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

Deliverables

HYPERDIAMOND Public website

Production of a public website to promote the project progress and results

Report on ND-probe hyperpolarization system

Development of hyperpolarization system at UULM for ND-probe hyperpolarization and imaging, to be used in conjunction with preclinical 7T MRI

Publications

Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues

Author(s): David Y. W. Ng, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener, Tanja Weil
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02020-2

Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates


Published in: ISSN 2198-3844
DOI: 10.1002/advs.201700897

Chemoselective Dual Labeling of Native and Recombinant Proteins

Author(s): Bikram Keshari Agrawalla, Tao Wang, Andreas Riegger, Matthias P. Domogalla, Kerstin Steinbrink, Thilo Dörfler, Xi Chen, Felix Boldt, Markus Lamla, Jens Michaelis, Seah Ling Kuan, Tanja Weil
Published in: Bioconjugate Chemistry, Issue 29/1, 2017, Page(s) 29-34, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.7b00675

Narrow-bandwidth sensing of high-frequency fields with continuous dynamical decoupling

Author(s): Alexander Stark, Nati Aharon, Thomas Unden, Daniel Louzon, Alexander Huck, Alex Retzker, Ulrik L. Andersen, Fedor Jelezko
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-01159-2

Fully robust qubit in atomic and molecular three-level systems

Author(s): N Aharon, I Cohen, F Jelezko, A Retzker
Published in: New Journal of Physics, Issue 18/12, 2016, Page(s) 123012, ISSN 1367-2630
DOI: 10.1088/1367-2630/aa4fd3

Enhanced quantum sensing with multi-level structures of trapped ions

Author(s): N Aharon, M Drewsen, A Retzker
Published in: Quantum Science and Technology, Issue 2/3, 2017, Page(s) 034006, ISSN 2058-9565
DOI: 10.1088/2058-9565/aa771a

Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins


Published in: ISSN 2198-3844
DOI: 10.1002/advs.201701036

Fluorescent Nanodiamond–Gold Hybrid Particles for Multimodal Optical and Electron Microscopy Cellular Imaging

Author(s): Weina Liu, Boris Naydenov, Sabyasachi Chakrabortty, Bettina Wuensch, Kristina Hübner, Sandra Ritz, Helmut Cölfen, Holger Barth, Kaloian Koynov, Haoyuan Qi, Robert Leiter, Rolf Reuter, Jörg Wrachtrup, Felix Boldt, Jonas Scheuer, Ute Kaiser, Miguel Sison, Theo Lasser, Philip Tinnefeld, Fedor Jelezko, Paul Walther, Yuzhou Wu, Tanja Weil
Published in: Nano Letters, Issue 16/10, 2016, Page(s) 6236-6244, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.6b02456

Comparative Study of Condensation Routes for Formation of Nano- and Microsized Carbon Forms in Hydrocarbon, Fluorocarbon, and Fluoro-Hydrocarbon Systems at High Pressures and Temperatures

Author(s): Valery A. Davydov, Viatcheslav Agafonov, Valery N. Khabashesku
Published in: The Journal of Physical Chemistry C, Issue 120/51, 2016, Page(s) 29498-29509, ISSN 1932-7447
DOI: 10.1021/acs.jpcc.6b10805

Unraveling In Vivo Brain Transport of Protein‐Coated Fluorescent Nanodiamonds


Published in: ISSN 1613-6810
DOI: 10.1002/smll.201902992

High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis

Author(s): Shen Han, Marco Raabe, Lorna Hodgson, Judith Mantell, Paul Verkade, Theo Lasser, Katharina Landfester, Tanja Weil, Ingo Lieberwirth
Published in: Nano Letters, Issue 19/3, 2019, Page(s) 2178-2185, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.9b00752

Synthesis of Precision Poly(1,3-adamantylene alkylene)s via Acyclic Diene Metathesis Polycondensation

Author(s): Jonas Friebel, Christopher P. Ender, Markus Mezger, Jasper Michels, Manfred Wagner, Kenneth B. Wagener, Tanja Weil
Published in: Macromolecules, Issue 52/12, 2019, Page(s) 4483-4491, ISSN 0024-9297
DOI: 10.1021/acs.macromol.9b00294

Enhancing the Robustness of Dynamical Decoupling Sequences with Correlated Random Phases

Author(s): Zhenyu Wang, Jorge Casanova, Martin B. Plenio
Published in: Symmetry, Issue 12/5, 2020, Page(s) 730, ISSN 2073-8994
DOI: 10.3390/sym12050730

Limited-control metrology approaching the Heisenberg limit without entanglement preparation

Author(s): Benedikt Tratzmiller, Qiong Chen, Ilai Schwartz, Susana F. Huelga, Martin B. Plenio
Published in: Physical Review A, Issue 101/3, 2020, Page(s) 032347, ISSN 2469-9926
DOI: 10.1103/physreva.101.032347

Randomization of Pulse Phases for Unambiguous and Robust Quantum Sensing

Author(s): Zhen-Yu Wang, Jacob E. Lang, Simon Schmitt, Johannes Lang, Jorge Casanova, Liam McGuinness, Tania S. Monteiro, Fedor Jelezko, Martin B. Plenio
Published in: Physical Review Letters, Issue 122/20, 2019, Page(s) 200403, ISSN 0031-9007
DOI: 10.1103/physrevlett.122.200403

Initialization and Readout of Nuclear Spins via a Negatively Charged Silicon-Vacancy Center in Diamond

Author(s): Mathias H. Metsch, Katharina Senkalla, Benedikt Tratzmiller, Jochen Scheuer, Michael Kern, Jocelyn Achard, Alexandre Tallaire, Martin B. Plenio, Petr Siyushev, Fedor Jelezko
Published in: Physical Review Letters, Issue 122/19, 2019, Page(s) 190503, ISSN 0031-9007
DOI: 10.1103/physrevlett.122.190503

Modulated Continuous Wave Control for Energy-Efficient Electron-Nuclear Spin Coupling

Author(s): J. Casanova, E. Torrontegui, M. B. Plenio, J. J. García-Ripoll, E. Solano
Published in: Physical Review Letters, Issue 122/1, 2019, Page(s) 010407, ISSN 0031-9007
DOI: 10.1103/physrevlett.122.010407

Protecting Quantum Spin Coherence of Nanodiamonds in Living Cells

Author(s): Q.-Y. Cao, P.-C. Yang, M.-S. Gong, M. Yu, A. Retzker, M.B. Plenio, C. Müller, N. Tomek, B. Naydenov, L.P. McGuinness, F. Jelezko, J.-M. Cai
Published in: Physical Review Applied, Issue 13/2, 2020, Page(s) 024021, ISSN 2331-7019
DOI: 10.1103/physrevapplied.13.024021

Impurities of [1-13C]Pyruvic Acid and a Method to Minimize Their Signals for Hyperpolarized Pyruvate Metabolism Studies

Author(s): Talia Harris, Ayelet Gamliel, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: Applied Magnetic Resonance, Issue 49/10, 2018, Page(s) 1085-1098, ISSN 0937-9347
DOI: 10.1007/s00723-018-1030-1

Hyperpolarized [15N]nitrate as a potential long lived hyperpolarized contrast agent for MRI

Author(s): Ayelet Gamliel, Sivaranjan Uppala, Gal Sapir, Talia Harris, Atara Nardi-Schreiber, David Shaul, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: Journal of Magnetic Resonance, Issue 299, 2019, Page(s) 188-195, ISSN 1090-7807
DOI: 10.1016/j.jmr.2019.01.001

1 H‐decoupling and Isotopic Labeling for the Measurement of the Longitudinal Relaxation Time of Hyperpolarized 13 C‐Methylenes in Choline Analogs

Author(s): Sivaranjan Uppala, Ayelet Gamliel, Talia Harris, Jacob Sosna, J. Moshe Gomori, Alexej Jerschow, Rachel Katz‐Brull
Published in: Israel Journal of Chemistry, Issue 59/11-12, 2019, Page(s) 1014-1019, ISSN 0021-2148
DOI: 10.1002/ijch.201900016

In-Cell Determination of Lactate Dehydrogenase Activity in a Luminal Breast Cancer Model – ex vivo Investigation of Excised Xenograft Tumor Slices Using dDNP Hyperpolarized [1-13C]pyruvate

Author(s): Yael Adler-Levy, Atara Nardi-Schreiber, Talia Harris, David Shaul, Sivaranjan Uppala, Gal Sapir, Naama Lev-Cohain, Jacob Sosna, Shraga Nahum Goldberg, J. Moshe Gomori, Rachel Katz-Brull
Published in: Sensors, Issue 19/9, 2019, Page(s) 2089, ISSN 1424-8220
DOI: 10.3390/s19092089

[13C6,D8]2-deoxyglucose phosphorylation by hexokinase shows selectivity for the β-anomer

Author(s): Gal Sapir, Talia Harris, Sivaranjan Uppala, Atara Nardi-Schreiber, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-56063-0

Differentiation of Heterogeneous Mouse Liver from HCC by Hyperpolarized 13C Magnetic Resonance

Author(s): Naama Lev-Cohain, Gal Sapir, Sivaranjan Uppala, Atara Nardi-Schreiber, Shraga Nahum Goldberg, Yael Adler-Levy, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Published in: Sci, Issue 2/1, 2020, Page(s) 3, ISSN 2413-4155
DOI: 10.3390/sci2010003

Synthesis and coherent properties of 13C-enriched sub-micron diamond particles with nitrogen vacancy color centers

Author(s): Yuliya Mindarava, Rémi Blinder, Yan Liu, Jochen Scheuer, Johannes Lang, Viatcheslav Agafonov, Valery A. Davydov, Christian Laube, Wolfgang Knolle, Bernd Abel, Boris Naydenov, Fedor Jelezko
Published in: Carbon, Issue 165, 2020, Page(s) 395-403, ISSN 0008-6223
DOI: 10.1016/j.carbon.2020.04.071

High‐Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple‐Negative Breast Cancer Xenografts

Author(s): Susanne Hafner, Marco Raabe, Yuzhou Wu, Tao Wang, Zhi Zuo, Volker Rasche, Tatiana Syrovets, Tanja Weil, Thomas Simmet
Published in: Advanced Therapeutics, Issue 2/11, 2019, Page(s) 1900084, ISSN 2366-3987
DOI: 10.1002/adtp.201900084

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Author(s): Sean Harvey, Marco Raabe, Anna Ermakova, Yingke Wu, Todd Zapata, Chaojian Chen, Hao Lu, Fedor Jelezko, David Y. W. Ng, Tanja Weil
Published in: Advanced Therapeutics, Issue 2/11, 2019, Page(s) 1900067, ISSN 2366-3987
DOI: 10.1002/adtp.201900067

Multi-Modal PET and MR Imaging in the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) Model for Initial In Vivo Testing of Target-Specific Radioligands

Author(s): Gordon Winter, Andrea B. F. Koch, Jessica Löffler, Mika Lindén, Christoph Solbach, Alireza Abaei, Hao Li, Gerhard Glatting, Ambros J. Beer, Volker Rasche
Published in: Cancers, Issue 12/5, 2020, Page(s) 1248, ISSN 2072-6694
DOI: 10.3390/cancers12051248

In vivo PET/MRI Imaging of the Chorioallantoic Membrane

Author(s): Gordon Winter, Andrea B. F. Koch, Jessica Löffler, Fedor Jelezko, Mika Lindén, Hao Li, Alireza Abaei, Zhi Zuo, Ambros J. Beer, Volker Rasche
Published in: Frontiers in Physics, Issue 8, 2020, ISSN 2296-424X
DOI: 10.3389/fphy.2020.00151

Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond

Author(s): Jonathan P. King, Keunhong Jeong, Christophoros C. Vassiliou, Chang S. Shin, Ralph H. Page, Claudia E. Avalos, Hai-Jing Wang, Alexander Pines
Published in: Nature Communications, Issue 6/1, 2015, ISSN 2041-1723
DOI: 10.1038/ncomms9965

Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications

Author(s): Sabyasachi Chakrabortty, Bikram Keshari Agrawalla, Anne Stumper, Naidu M Vegi, Stephan Fischer, Christian Reichardt, Michael Kögler, Benjamin Dietzek, Michaela Feuring-Buske, Christian Buske, Sven Rau, Tanja Weil
Published in: Journal of the American Chemical Society, Issue 139/6, 2017, Page(s) 2512-2519, ISSN 0002-7863
DOI: 10.1021/jacs.6b13399

The CAM cancer xenograft as a model for initial evaluation of MR labelled compounds

Author(s): Zhi Zuo, Tatiana Syrovets, Yuzhou Wu, Susanne Hafner, Ina Vernikouskaya, Weina Liu, Genshan Ma, Tanja Weil, Thomas Simmet, Volker Rasche
Published in: Scientific Reports, Issue 7, 2017, Page(s) 46690, ISSN 2045-2322
DOI: 10.1038/srep46690

Steady-state preparation of long-lived nuclear spin singlet pairs at room temperature

Author(s): Q. Chen, I. Schwarz, M. B. Plenio
Published in: Physical Review B, Issue 95/22, 2017, ISSN 2469-9950
DOI: 10.1103/PhysRevB.95.224105

Dissipatively Stabilized Quantum Sensor Based on Indirect Nuclear-Nuclear Interactions

Author(s): Q. Chen, I. Schwarz, M. B. Plenio
Published in: Physical Review Letters, Issue 119/1, 2017, ISSN 0031-9007
DOI: 10.1103/PhysRevLett.119.010801

Resonance-inclined optical nuclear spin polarization of liquids in diamond structures

Author(s): Q. Chen, I. Schwarz, F. Jelezko, A. Retzker, M. B. Plenio
Published in: Physical Review B, Issue 93/6, 2016, ISSN 2469-9950
DOI: 10.1103/PhysRevB.93.060408

Coherent control of solid state nuclear spin nano-ensembles

Author(s): Unden, Thomas; Tomek, Nikolas; Weggler, Timo; Frank, Florian; London, Paz; Zopes, Jonathan; Degen, Christian; Raatz, Nicole; Meijer, Jan; Watanabe, Hideyuki; Itoh, Kohei M.; Plenio, Martin B.; Naydenov, Boris; Jelezko, Fedor
Published in: Issue 1, 2018

Limits on spectral resolution measurements by quantum probes

Author(s): Rotem, Amit; Gefen, Tuvia; Schmitt, Simon; McGuiness, Liam; Jelezko, Fedor; Retzker, Alex
Published in: Issue 1, 2017

Protecting a nuclear spin from a noisy electron spin in diamond

Author(s): Cohen, Itsik; Unden, Thomas; Jelezko, Fedor; Retzker, Alex
Published in: Issue 1, 2017

13C Longitudinal Relaxation Times Assessment in the Search for Advanced Applications of Nanodiamonds in Medicine

Author(s): Pavleta Tzvetkova, Christian Jentgens, Ilai Schwarz, Martin Plenio, Burkhard Luy
Published in: ENC, Issue 26/03/2017, 2017

13C enriched nanodiamonds and “core-shell” diamond particles as hyperpolarized MRI agents

Author(s): Y.L. Mindarava , R. Blinder, V.N. Agafonov, V. A. Davydov, C. Laube , W.B. Abel , B.Naydenov, and F. Jelezko
Published in: 2nd Smart Nanomaterials Conference, ENSCP, Paris, Décembre 10-13, 2019., 2019

Optically-induced Dynamical Nuclear Polarization in Diamond Materials

Author(s): Rémi Blinder, Yuliya Mindarava, Jochen Scheuer, Tobias Speidel, Christian Laube, Viatcheslav N. Agafonov, Valery A. Davydov, Volker Rashe, Fedor Jelezko
Published in: The 52nd Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry. 7 - 11 April 2019, Glasgow, GB, 2019

Room temperature optically induced dynamic nuclear polarization in diamond

Author(s): Yuliya Mindarava, Remi Blinder, Jochen Scheuer, Christian Laube, Viatcheslav N. Agafonov, Valery A. Davydov, Fedor Jelezko.
Published in: International Conference on New Diamond and Nano Carbon 2019 May 12-17, 2019, Hualien, Taiwan, 2019

HPHT synthesis of nano-sized diamonds doped with Si or 13C for biological and medical applications




Synthesis and characterization of micro and nanodiamond particles doped with Nitrogen –Vacancy centers

Author(s): Yuliya Mindarava , Rémi Blinder, Jochen Scheuer, Tobias Speidel, Christian Laube, Viatcheslav N. Agafonov, Valery A. Davydov, Volker Rashe, Fedor Jelezko.
Published in: The 25th meeting of the international Hasselt Diamond Workshop, 2020

Mixed Dynamical Decoupling

Author(s): Genov, Genko T.; Aharon, Nati; Jelezko, Fedor; Retzker, Alex
Published in: Quantum Physics, Issue 1, 2019

On the robustness of the NV-NMR spectrometer setup to magnetic field inhomogeneities

Author(s): Yotam Vaknin, Benedikt Tratzmiller, Tuvia Gefen, Ilai Schwartz, Martin Plenio, Alex Retzker
Published in: E-print arXiv, Issue 2002.10852, 2020

Giant shift upon strain on the fluorescence spectrum of VNNB color centers in h-BN

Author(s): Song Li, Jyh-Pin Chou, Alice Hu, Martin B. Plenio, Péter Udvarhelyi, Gergő Thiering, Mehdi Abdi, Adam Gali
Published in: E-print arXiv, Issue 2001.02749, 2020

Decoherence-Free Rotational Degrees of Freedom for Quantum Applications

Author(s): Julen S. Pedernales, Francesco Cosco, Martin B. Plenio
Published in: E-print arXiv, Issue 2001.00826, 2020

Motional Dynamical Decoupling for Matter-Wave Interferometry

Author(s): Julen S. Pedernales, Gavin W. Morley, Martin B. Plenio
Published in: E-print arXiv, Issue 1906.00835, 2019