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The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

Objective

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous potential for socioeconomic relevant diseases. E.g. pyruvate-based hyperpolarized imaging was clinically demonstrated to be effective for prostate cancer diagnostics in human patients. However, the current state-of-the-art hyperpolarization methods are expensive and cumbersome, limiting the access to hyperpolarization technology, and require long hyperpolarization times of 60-90 minutes per dosage; hyperpolarization probes exhibit short hyperpolarization duration (1-5 minutes), limiting the usage of hyperpolarization to metabolic imaging. A quantum technological breakthrough, Nitrogen-Vacancy defects (NV centres) in diamonds, is set to revolutionize the field of hyperpolarization for both hyperpolarizer and probes.
The primary objective of HYPERDIAMOND is the development and commercialization of two new molecular imaging technologies for sensitive diagnosis and treatment monitoring, based on NV centres:
The Diamond Hyperpolarizer will offer a cost- and time-effective solution for hyperpolarization that easily fits current MRI layouts, hyperpolarizes within 5 minutes, and improves clinical viability. The Nano-diamond (ND) Probe will introduce the first targeted MRI probe capable of achieving comparable molecular sensitivity to positron emission tomography (PET) with MRI systems, exhibiting extremely long hyperpolarization duration (~1 hour), and enabling non-metabolic hyperpolarized imaging.
HYPERDIAMOND will bridge the gap between novel quantum and nanotechnology and their applications in hyperpolarized imaging, producing innovation not feasible with current technology.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /engineering and technology/nanotechnology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/prostate cancer

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAET ULM
Address
Helmholtzstrasse 16
89081 Ulm
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 233 863,23

Participants (10)

THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 200 150
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
NVISION IMAGING TECHNOLOGIES GMBH
Germany
EU contribution
€ 685 625
Address
Albert-einstein-allee
89081 Ulm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE TOURS
France
EU contribution
€ 627 382,49
Address
Rue Du Plat D Etain 60
37020 Tours
Activity type
Higher or Secondary Education Establishments
RESEARCH FUND OF THE HADASSAH MEDICAL ORGANIZATION (R.A)
Israel
EU contribution
€ 427 750
Address
Kiryat Hadassah Ein Karem
91120 Jerusalem
Activity type
Research Organisations
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 390 125
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU contribution
€ 379 661,25
Address
Giefinggasse 4
1210 Wien
Activity type
Research Organisations
LM VAN MOPPES AND SONS SA
Switzerland
EU contribution
€ 0
Address
Avenue De La Praille 55
1211 Carouge Ge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARTTIC
France
EU contribution
€ 282 580
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KANFIT LTD
Israel
EU contribution
€ 272 805
Address
4 Shaul Amor Avenue Ramat Gavriel Industrial Zone
2353004 Migdal Ha-emek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 366 108,03
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations