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Investigating the impact of meditation training on mental health and wellbeing in the ageing population

Objectif

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potential to downregulate these adverse factors and positively impact mental and neurological conditions including AD. Our main objectives are i) to improve early AD detection and understanding of physiopathological mechanisms; and to investigate ii) the impact of internal/external (e.g. genetic and lifestyle) determinants and iii) the effect and mechanisms of action of meditation training, on mental health and wellbeing in older people. This will be achieved by using pre-existing databases from European partners and conducting two randomized controlled trials (Studies 1 and 2B) and one observational study (2A). STUDY 1 will assess the short-term effects of an 8-week meditation intervention (versus cognitive training) in patients with subjective cognitive decline at risk for AD on behavioural measures including anxiety and wellbeing. STUDY 2A will assess senior expert meditators to identify neural signatures of different meditation practices on attention and emotion regulation tasks. STUDY 2B will assess long-term effects of an 18-month meditation intervention (versus an active control) on behavioural and biological markers of mental health and wellbeing in cognitively intact elderly. The cognitive and affective regulatory mechanisms underlying these effects will be investigated using the neural signatures identified in the expert meditators. High public health relevance is likely: the proposed intervention targets the most common mental and neurological conditions in the elderly and it can be scaled up within preventive programmes at a population level.

Champ scientifique

  • /sciences médicales et de la santé/sciences de la santé/santé publique et environnementale
  • /sciences médicales et de la santé/médecine fondamentale/neurologie/alzheimer

Appel à propositions

H2020-PHC-2015-two-stage
Voir d’autres projets de cet appel

Régime de financement

RIA - Research and Innovation action
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Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Rue De Tolbiac 101
75654 Paris
France
Type d’activité
Research Organisations
Contribution de l’UE
€ 4 149 616,31

Participants (10)

UNIVERSITE DE LIEGE
Belgique
Contribution de l’UE
€ 276 250
Adresse
Place Du 20 Aout 7
4000 Liege
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Suisse
Contribution de l’UE
€ 0
Adresse
Rue Du General Dufour 24
1211 Geneve
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 649 646,44
Adresse
Gower Street
WC1E 6BT London
Type d’activité
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET ZU KOELN
Allemagne
Contribution de l’UE
€ 120 000
Adresse
Kerpener Strasse 62
50937 Koeln
Type d’activité
Higher or Secondary Education Establishments
HOSPICES CIVILS DE LYON
France
Contribution de l’UE
€ 100 500
Adresse
Quai Des Celestins 3
69002 Lyon
Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Espagne
Contribution de l’UE
€ 112 687,50
Adresse
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Type d’activité
Other
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Contribution de l’UE
€ 113 635
Adresse
5 Rue Watt
75013 Paris
Type d’activité
Research Organisations
INSERM TRANSFERT SA
France
Contribution de l’UE
€ 139 175
Adresse
Rue Watt 7
75013 Paris
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MINERVA HEALTH & CARE COMMUNICATIONS LTD
United Kingdom
Contribution de l’UE
€ 412 875
Adresse
Unit 16, Basepoint Business & Innova
SP10 3FG Andover Hampshire
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF EXETER
United Kingdom
Contribution de l’UE
€ 60 371
Adresse
The Queen's Drive Northcote House
EX4 4QJ Exeter
Type d’activité
Higher or Secondary Education Establishments