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Development of closed, scalable and AUTOmated robotic systems for therapeutic STEM cell manufacturing: aseptic systems from “Donor-to-Patient”

Objective

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery.

AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies.

The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 849 375

Participants (9)

UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 450 000
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 207 041,25
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 757 353,75
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
PINTAIL LTD
Ireland
EU contribution
€ 250 000
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CROSPON LIMITED
Ireland
EU contribution
€ 685 000
Address
Galway Business Park Dangan
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZELLWERK GMBH
Germany
EU contribution
€ 498 750
Address
Ziegeleistrasse 7
16727 Oberkramer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELL THERAPY CATAPULT LIMITED
United Kingdom
EU contribution
€ 299 952,50
Address
12Th Floor Tower Wing Guy's Hospital Great Maze Pond
SE1 9RT London
Activity type
Research Organisations
ASTON UNIVERSITY
United Kingdom
EU contribution
€ 549 913,75
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
ORBSEN THERAPEUTICS LIMITED
Ireland
EU contribution
€ 448 375
Address
Unit 1 Galway Business Park
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)