Objective
AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery.
AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies.
The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
H91 Galway
Ireland
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Participants (9)
16126 Genova
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80686 Munchen
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T12 YN60 Cork
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A94 K542 Blackrock
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
H91 Galway
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16727 Oberkramer
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
SE1 9RT London
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
B4 7ET Birmingham
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H91 Galway
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.