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Continuous Regional Analysis Device for neonate Lung

Objective

Each year 15 million babies are born prematurely and many suffer from respiratory failure due to immaturity of the lung and lack of control of breathing. Although respiratory support, especially mechanical ventilation, can improve their survival, it also causes severe injury to the vulnerable lung resulting in severe and chronic pulmonary morbidity lasting in to adulthood. Heterogeneity of lung aeration, resulting in areas of lung over inflation and lung collapse, plays a crucial part in the risk of mortality and morbidity due to respiratory failure. This distribution of lung aeration cannot be detected by currently available bedside monitoring tools and imaging methods. Thus, an imaging technique for continuous non-invasive bedside monitoring of infants lung function is urgently needed. In order to address this, CRADL will use EIT technology to establish a monitoring tool for interventions in the paediatric population.
Electrical impedance tomography (EIT) is a non-radiative, inexpensive technique that can facilitate real time dynamic monitoring of lung aeration, and recent studies have shown that it is effective in monitoring aeration in preterm babies. CRADL will show how EIT can provide new cost effective, easy to use, respiratory management tools and clinical protocols that can be universally adopted to reduce deaths and disability in preterm babies by delivering a tool that provides continuous, non-invasive, radiation free, bedside information on regional lung aeration and ventilation during daily clinical care of (preterm) infants and children with respiratory failure. CRADL will also assess the effectiveness, efficacy and safety of such a system in guiding respiratory management and supportive care of the most common causes of paediatric respiratory failure (respiratory distress syndrome, bronchiolitis and acute respiratory distress syndrome), with the final goal of reducing short and long term adverse effects of disease and its treatment in this populat

Field of science

  • /natural sciences/computer and information sciences/data science/data analysis
  • /medical and health sciences/clinical medicine/paediatrics
  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION
Address
The Burroughs, Hendon .
NW4 4BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 997 500

Participants (10)

UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 1 067 302,50
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 514 690
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Ministry of Health of the Republic of Cyprus
Cyprus
EU contribution
€ 137 500
Address
1 Prodromou Street & 17 Chilonos Street 1 & 17
1448 Nicosia
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FILANTHROPIKO IDRYMA VIOIATRIKON EREVNON
Cyprus
EU contribution
€ 162 500
Address
Po Box 24039
1700 Lefkosia
Activity type
Other
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 0
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
LINNEUNIVERSITETET
Sweden
EU contribution
€ 355 025
Address
Linnaeus University
35195 Vaxjo
Activity type
Higher or Secondary Education Establishments
SENTEC AG
Switzerland
EU contribution
€ 0
Address
Ringstrasse 39
4106 Therwil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 323 750
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
STUDIO FIFIELD SRL
Italy
EU contribution
€ 584 062,50
Address
Via Pietro Colletta 69
20137 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANAXEA BV
Netherlands
EU contribution
€ 92 000
Address
Science Park 400 Matrix Ii Unit 3.1
1098 XH Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)