Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes

Project Information

LSFM4LIFE

Grant agreement ID: 668350

DOI 10.3030/668350

Project closed

EC signature date 3 December 2015

Start date 1 January 2016

End date 31 December 2019

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 120 275,00

EU contribution € 4 666 400,00

Coordinated by

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

Deliverables

Websites, patent fillings, videos etc. (4)

"Newsletter #1"

"D2.5: Newsletter #1 (M12)"

Project website

D2.2: Project website (M03)

Project-related video

D2.7: Project-related video (M24)

Communication materials: Leaflet, poster, presentation and infographics to present the project

D2.4: Communication materials: Leaflet, poster, presentation and infographics to present the project (M06)

Publications

Peer reviewed articles (10)

Universality of clone dynamics during tissue development

Author(s): Steffen Rulands, Fabienne Lescroart, Samira Chabab, Christopher J. Hindley, Nicole Prior, Magdalena K. Sznurkowska, Meritxell Huch, Anna Philpott, Cedric Blanpain, Benjamin D. Simons
Published in: Nature Physics, Issue 14/5, 2018, Page(s) 469-474, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-018-0055-6

Tips and Tricks for Validation of Quality Control Analytical Methods in Good Manufacturing Practice Mesenchymal Stromal Cell Production

Author(s): Mariele Viganò, Silvia Budelli, Cristiana Lavazza, Tiziana Montemurro, Elisa Montelatici, Stefania de Cesare, Lorenza Lazzari, Anna Rosa Orlandi, Giovanna Lunghi, Rosaria Giordano
Published in: Stem Cells International, Issue 2018, 2018, Page(s) 1-16, ISSN 1687-966X
Publisher: Hindawi
DOI: 10.1155/2018/3038565

Challenges of running a GMP facility for regenerative medicine in a public hospital

Author(s): Mariele Viganò, Rosaria Giordano, Lorenza Lazzari
Published in: Regenerative Medicine, Issue 12/7, 2017, Page(s) 803-813, ISSN 1746-0751
Publisher: Future Medicine Ltd.
DOI: 10.2217/rme-2017-0051

The hope and the hype of organoid research

Author(s): Meritxell Huch, Juergen A. Knoblich, Matthias P. Lutolf, Alfonso Martinez-Arias
Published in: Development, Issue 144/6, 2017, Page(s) 938-941, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.150201

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Author(s): Laura Broutier, Gianmarco Mastrogiovanni, Monique MA Verstegen, Hayley E Francies, Lena Morrill Gavarró, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E Davies, Raaj K Praseedom, Ruby Lieshout, Jan N M IJzermans, Stephen J Wigmore, Kourosh Saeb-Parsy, Mathew J Garnett, Luc JW van der Laan,
Published in: Nature Medicine, Issue 23/12, 2017, Page(s) 1424-1435, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4438

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids

Author(s): Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Published in: BMC Developmental Biology, Issue 20/1, 2020, ISSN 1471-213X
Publisher: BioMed Central
DOI: 10.1186/s12861-020-0209-5

Standardized GMP-compliant scalable production of human pancreas organoids

Author(s): Marta Dossena, Roberta Piras, Alessandro Cherubini, Mario Barilani, Erica Dugnani, Francesca Salanitro, Till Moreth, Francesco Pampaloni, Lorenzo Piemonti, Lorenza Lazzari
Published in: Stem Cell Research & Therapy, Issue 11/1, 2020, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-020-1585-2

Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens

Author(s): Katharina Hötte, Michael Koch, Lotta Hof, Marcel Tuppi, Till Moreth, Monique M. A. Verstegen, Luc J. W. van der Laan, Ernst H. K. Stelzer, Francesco Pampaloni
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-53380-2

Quantitative three-dimensional evaluation of immunofluorescence staining for large whole mount spheroids with light sheet microscopy

Author(s): I. Smyrek, E. H. K. Stelzer
Published in: Biomedical Optics Express, Issue 8/2, 2017, Page(s) 484, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.8.000484

A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover

Author(s): Francesco Pampaloni, Benjamin Mayer, Konstantin Kabat Vel-Job, Nariman Ansari, Katharina Hötte, Donat Kögel, Ernst H. K. Stelzer
Published in: SLAS DISCOVERY: Advancing Life Sciences R&D, Issue 22/5, 2017, Page(s) 558-570, ISSN 2472-5552
Publisher: SAGE journals
DOI: 10.1177/2472555217696798