Role of Apolipoproteins L in immunity and disease

Project Information

APOLs

Grant agreement ID: 669007

DOI 10.3030/669007

Project closed

EC signature date 7 August 2015

Start date 1 September 2015

End date 30 June 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 250 000,00

EU contribution € 2 250 000,00

Coordinated by

UNIVERSITE LIBRE DE BRUXELLES
Belgium

Publications

Peer reviewed articles (12)

The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection

Author(s): Etienne Pays
Published in: The FEBS Journal, Issue 288/2, 2021, Page(s) 360-381, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15444

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

Author(s): Laurence Lecordier, Sophie Uzureau, Gilles Vanwalleghem, Magali Deleu, Jean-Marc Crowet, Paul Barry, Barry Moran, Paul Voorheis, Andra-Cristina Dumitru, Yoshiki Yamaryo-Botté, Marc Dieu, Patricia Tebabi, Benoit Vanhollebeke, Laurence Lins, Cyrille Y. Botté, David Alsteens, Yves Dufrêne, David Pérez-Morga, Derek P. Nolan, Etienne Pays
Published in: iScience, Issue 23/9, 2020, Page(s) 101476, ISSN 2589-0042
Publisher: NA
DOI: 10.1016/j.isci.2020.101476

The Mechanism of Kidney Disease Due to APOL1 Risk Variants

Author(s): Etienne Pays
Published in: Journal of the American Society of Nephrology, Issue 31/11, 2020, Page(s) 2502-2505, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2020070954

APOLs with low pH dependence can kill all African trypanosomes

Author(s): Frédéric Fontaine, Laurence Lecordier, Gilles Vanwalleghem, Pierrick Uzureau, Nick Van Reet, Martina Fontaine, Patricia Tebabi, Benoit Vanhollebeke, Philippe Büscher, David Pérez-Morga, Etienne Pays
Published in: Nature Microbiology, Issue 2/11, 2017, Page(s) 1500-1506, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-017-0034-1

Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Author(s): Gilles Vanwalleghem, Yannick Morias, Alain Beschin, David E. Szymkowski, Etienne Pays
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-06496-2

Specific Endocytosis Blockade of Trypanosoma cruzi Exposed to a Poly-LAcNAc Binding Lectin Suggests that Lectin-Sugar Interactions Participate to Receptor-Mediated Endocytosis

Author(s): Sébastien Brosson, Frédéric Fontaine, Marjorie Vermeersch, David Perez-Morga, Etienne Pays, Sabrina Bousbata, Didier Salmon
Published in: PLOS ONE, Issue 11/9, 2016, Page(s) e0163302, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0163302

Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.

Author(s): Uzureau, S., Coquerelle, C., Uzureau, P., Vermeiren, C., Pilotte, L., Van Acker, A., Acolty, V., Vanhollebeke, B., Van den Eynde, B., Moser, M., and Pays, E.
Published in: European Journal of Immunology, 2016, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201546252

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

Author(s): Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M. La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K. Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Pé
Published in: Cell Reports, Issue 30/11, 2020, Page(s) 3821-3836.e13, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.02.064

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection

Author(s): Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve
Published in: mBio, Issue 7/2, 2016, ISSN 2150-7511
Publisher: The American Society for Microbiology
DOI: 10.1128/mBio.02198-15

Genetic and immunological basis of human African trypanosomiasis

Author(s): Etienne Pays, Derek P Nolan
Published in: Current Opinion in Immunology, Issue 72, 2021, Page(s) 13-20, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2021.02.007

APOL1 variant–associated kidney disease: from trypanosomes to podocyte cytoskeleton

Author(s): Etienne Pays
Published in: Kidney International, Issue 98/6, 2020, Page(s) 1373-1377, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2020.07.034

Multiparametric Atomic Force Microscopy Identifies Multiple Structural and Physical Heterogeneities on the Surface of Trypanosoma brucei

Author(s): Claire Valotteau, Andra C. Dumitru, Laurence Lecordier, David Alsteens, Etienne Pays, David Pérez-Morga, Yves F. Dufrêne
Published in: ACS Omega, Issue 5/33, 2020, Page(s) 20953-20959, ISSN 2470-1343
Publisher: NA
DOI: 10.1021/acsomega.0c02416