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Characterising protein oligomers and their role in neurodegenerative disease in humans

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Publications

Optical structural analysis of individual α-synuclein oligomers


Published in: ISSN 1433-7851
DOI: 10.1002/anie.201710779

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Author(s): Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H. Horrocks, Magnus Kjaergaard, Sarah L. Shammas, Sophie E. Jackson, Christopher M. Dobson, David Klenerman
Published in: ACS Chemical Biology, Issue 12, 2018, ISSN 1554-8929
DOI: 10.1021/acschembio.7b01039

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Author(s): Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, Craig D. Hughes, Francesco S. Ruggeri, Tim Guilliams, Alexander K. Buell, Ji-Eun Lee, Sonia Gandhi, Steven F. Lee, Clare E. Bryant, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
Published in: BMC Biology, Issue 15/1, 2017, ISSN 1741-7007
DOI: 10.1186/s12915-017-0390-6

Inhibiting the Ca 2+ Influx Induced by Human CSF

Author(s): Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Published in: Cell Reports, Issue 21/11, 2017, Page(s) 3310-3316, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.11.057

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

Author(s): Daniel R. Whiten, Dezerae Cox, Mathew H. Horrocks, Christopher G. Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R. Kumita, Heath Ecroyd, Christopher M. Dobson, David Klenerman, Mark R. Wilson
Published in: Cell Reports, Issue 23/12, 2018, Page(s) 3492-3500, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.05.074

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Author(s): Kundel, F.; Hong, L.; Falcon, B.; McEwan, W. A.; Michaels, T. C. T.; Meisl, G.; Esteras, N.; Abramov, A. Y.; Knowles, T. J. P.; Goedert, M.; Klenerman, D.
Published in: ACS Chemical Neuroscience (2018), 2018, Page(s) 1276–1282, ISSN 1948-7193
DOI: 10.17863/CAM.25419

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

Author(s): Christopher G. Taylor, Georg Meisl, Mathew H. Horrocks, Henrik Zetterberg, Tuomas P. J. Knowles, David Klenerman
Published in: Analytical Chemistry, Issue 90/17, 2018, Page(s) 10385-10393, ISSN 0003-2700
DOI: 10.1021/acs.analchem.8b02226

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells

Author(s): Anna Drews, Jennie Flint, Nadia Shivji, Peter Jönsson, David Wirthensohn, Erwin De Genst, Cécile Vincke, Serge Muyldermans, Chris Dobson, David Klenerman
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep31910

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Author(s): Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-09477-3

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

Author(s): Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0777-4

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

Author(s): Ji-Eun Lee, Jason C. Sang, Margarida Rodrigues, Alexander R. Carr, Mathew H. Horrocks, Suman De, Marie N. Bongiovanni, Patrick Flagmeier, Christopher M. Dobson, David J. Wales, Steven F. Lee, David Klenerman
Published in: Nano Letters, Issue 18/12, 2018, Page(s) 7494-7501, ISSN 1530-6984
DOI: 10.1021/acs.nanolett.8b02916

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Author(s): Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, Juan A. Botía, Maria Iljina, Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Published in: Acta Neuropathologica, Issue 137/1, 2019, Page(s) 103-120, ISSN 0001-6322
DOI: 10.1007/s00401-018-1907-y

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Author(s): Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Published in: Communications Biology, Issue 3/1, 2020, ISSN 2399-3642
DOI: 10.1038/s42003-020-0792-9

Quantifying Co-Oligomer Formation by α-Synuclein

Author(s): Marija Iljina, Alexander J. Dear, Gonzalo A. Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R. Whiten, Thomas C. T. Michaels, Daan Frenkel, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Published in: ACS Nano, Issue 12/11, 2018, Page(s) 10855-10866, ISSN 1936-0851
DOI: 10.1021/acsnano.8b03575